Histidine Intake May Negatively Correlate with Energy Intake in Human: A Cross-Sectional Study in Japanese Female Students Aged 18 Years

Okubo, Hitomi; Sasaki, Satoshi

doi:10.3177/jnsv.51.329

Cited by 12 publications

(10 citation statements)

References 30 publications

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“…acid metabolism disorder and inflammation and/or oxidative stress, which suggests that more attention has to be paid to uncovering amino acid metabolism in obese individuals in a further study. In addition, previous studies have shown that women are more sensitive to dietary histidine and energy intake than men (42,43) . Therefore, we chose female rats as the experimental animals in the present study.…”

Section: Discussionmentioning

confidence: 97%

Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-κB- and PPARγ-involved pathways

Sun

Feng

et al. 2014

Br J Nutr

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Obesity is considered to be accompanied by a chronic low-grade inflammatory state that contributes to the occurrence of many chronic diseases. Our previous study has demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women. However, the in vivo potential mechanisms are not known. The present study was conducted to investigate the mechanisms underlying the effects of histidine on inflammation in a high-fat diet (HFD)-induced female obese rat model. An obese model was established in female Sprague -Dawley rats by HFD feeding for 8 weeks and followed by histidine supplementation for another 4 weeks. The results revealed that HFD-increased body weight and HFD-lowered serum histidine concentrations were significantly reversed by histidine supplementation (P, 0·05). In addition, the serum concentrations of TNF-a, IL-6, C-reactive protein (CRP) and malondialdehyde were significantly reduced and those of superoxide dismutase (SOD) were significantly increased by histidine supplementation when compared with those in obese rats (P,0·05). Correspondingly, the mRNA expressions of TNF-a, IL-6 and CRP in the adipose tissue were significantly down-regulated and that of CuZnSOD was significantly up-regulated by histidine supplementation (P,0·05). Histidine supplementation significantly reduced the HFD-induced translocation of NF-kB p65 into the nucleus (P¼ 0·032) by reducing the phosphorylation of the inhibitor of kBa in the adipose tissue. The results also revealed that the expression of adiponectin was markedly increased both in the serum and in the adipose tissue after histidine supplementation, accompanied by the activation of PPARg (P¼ 0·021). These findings indicate that histidine is an effective candidate for ameliorating inflammation and oxidative stress in obese individuals via the NF-kB-and PPARg-involved pathways.

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Section: Discussionmentioning

confidence: 97%

Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-κB- and PPARγ-involved pathways

Sun

Feng

et al. 2014

Br J Nutr

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“…Because previous studies found that women were more sensitive to dietary histidine and energy intake than men [14,36], we chose women to participate in our study. Therefore, the findings may not be generalised to the total population.…”

Section: Discussionmentioning

confidence: 99%

“…According to the histidine intake and supplementation described in previous studies [13][14][15][16], we recruited 20 obese female university students for the pilot experiment, randomly assigned into two groups: ten women took two 1 g histidine tablets after breakfast and two tablets after dinner (4 g/day histidine) and the other ten women took four tablets after breakfast and four tablets after dinner (8 g/day histidine) for 2 weeks. During the supplementation period, no side effects were reported and serum superoxide dismutase (SOD) was increased in both groups at the secondweek (data not shown).…”

Section: Methodsmentioning

confidence: 99%

Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial

et al. 2013

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Aims/hypothesis Increased inflammation and oxidative stress are associated with insulin resistance (IR) and metabolic disorders. Serum histidine levels are lower and are negatively associated with inflammation and oxidative stress in obese women. The objective of this study was to evaluate the efficacy of histidine supplementation on IR, inflammation, oxidative stress and metabolic disorders in obese women with the metabolic syndrome (MetS). Methods A total of 100 obese women aged 33-51 years with BMI≥28 kg/m 2 and diagnosed with MetS were included following a health examination in the community hospital in this randomised, double-blinded, placebo-controlled trial. Participants were allocated to interventions by an investigator using sequentially numbered sealed envelopes and received 4 g/day histidine (n=50) or identical placebo (n=50) for 12 weeks. Participants then attended the same clinic every 2 weeks for scheduled interviews and to count tablets returned. Serum histidine, HOMA-IR, BMI, waist circumference, fat mass, serum NEFA, and variables connected to inflammation and oxidative stress were measured at baseline and 12 weeks. Participants, examining physicians and investigators assessing the outcomes were blinded to group assignment. In addition, the inflammatory mechanisms of histidine were also explored in adipocytes. CI 0.60, 3.44] in histidine supplementation group (n=45), respectively. There were significant correlations between changes in serum histidine and changes of IR and its risk factors. No side effects were observed during the intervention. In vitro study indicated that histidine suppresses IL6 and TNF mRNA expression and nuclear factor kappa-B (NF-κB) protein production in palmitic acid-induced adipocytes in a dose-dependent manner, and these changes were diminished by an inhibitor of NF-κB. Conclusions/interpretation Histidine supplementation could improve IR, reduce BMI, fat mass and NEFA and suppress inflammation and oxidative stress in obese women with MetS; histidine could improve IR through suppressed pro-inflammatory cytokine expression, possibly by the NF-κB pathway, in adipocytes. Trial registration www.chictr.org/cn/ChiCTR-TRC-11001551Electronic supplementary material The online version of this article

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“…Daily HIS intake correlated inversely with energy intake. [119] Internet-based cross-sectional study in a Chinese population (n = 88).…”

Section: Decrease In Fasting Plasma Glucose Levelsmentioning

confidence: 99%

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

2020

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L-histidine (HIS) is an essential amino acid with unique roles in proton buffering, metal ion chelation, scavenging of reactive oxygen and nitrogen species, erythropoiesis, and the histaminergic system. Several HIS-rich proteins (e.g., haemoproteins, HIS-rich glycoproteins, histatins, HIS-rich calcium-binding protein, and filaggrin), HIS-containing dipeptides (particularly carnosine), and methyl- and sulphur-containing derivatives of HIS (3-methylhistidine, 1-methylhistidine, and ergothioneine) have specific functions. The unique chemical properties and physiological functions are the basis of the theoretical rationale to suggest HIS supplementation in a wide range of conditions. Several decades of experience have confirmed the effectiveness of HIS as a component of solutions used for organ preservation and myocardial protection in cardiac surgery. Further studies are needed to elucidate the effects of HIS supplementation on neurological disorders, atopic dermatitis, metabolic syndrome, diabetes, uraemic anaemia, ulcers, inflammatory bowel diseases, malignancies, and muscle performance during strenuous exercise. Signs of toxicity, mutagenic activity, and allergic reactions or peptic ulcers have not been reported, although HIS is a histamine precursor. Of concern should be findings of hepatic enlargement and increases in ammonia and glutamine and of decrease in branched-chain amino acids (valine, leucine, and isoleucine) in blood plasma indicating that HIS supplementation is inappropriate in patients with liver disease.

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Histidine Intake May Negatively Correlate with Energy Intake in Human: A Cross-Sectional Study in Japanese Female Students Aged 18 Years

Cited by 12 publications

References 30 publications

Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-κB- and PPARγ-involved pathways

Histidine supplementation alleviates inflammation in the adipose tissue of high-fat diet-induced obese rats via the NF-κB- and PPARγ-involved pathways

Histidine supplementation improves insulin resistance through suppressed inflammation in obese women with the metabolic syndrome: a randomised controlled trial

Histidine in Health and Disease: Metabolism, Physiological Importance, and Use as a Supplement

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