Fluvoxamine?A new serotonin re-uptake inhibitor: First clinical and psychometric experiences in depressed patients

Abstract

The clinical efficacy of fluvoxamine (DU 23000)--the first selective serotonin re-uptake inhibitor of the new class of 2-aminoethyloximethers of aralkylketones was investigated in endormorphous depressed patients during 5 weeks treatment with mean daily dosages of approximately 150 mg DU 23000. A marked and statistically significant improvement of the overall and detailed psychopathology was noted by means of the Global Clinical Impression and Hamilton Rating Scale as early as in the first week of drug administration. Bipolar patients tended to improve more than unipolar ones, retarded depressions more than agitated ones. An additional anxiolytic medication was occasionally required. The drug was well tolerated. Psychometric and laboratory findings did not show any significant changes. The findings are discussed in the light of the indolamine hypothesis of depression.

A placebo controlled study of the cardiovascular effects of fluvoxamine and clovoxamine in human volunteers.

“…The these studies confirm the safety and tolerance as well as the predicted antidepressant effects (Doogan, 1980;Saletu et al, 1977;Wright & Derlber, 1978;Klok et al, 1981;Freeman et al, 1981). The maximum doses of fluvoxamine and clovoxamine prescribed in human experiments have been 400 mg/day.…”

Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations

“…While only one clinical case of fluvoxamine-induced torsade de pointes has been reported (Manet et al, 1993), bradycardic action (de Wilde et al, 1983;Granfors et al, 2004;Pacher and Kecskemeti, 2004;Saletu et al, 1977), QT-interval prolongation (Klok et al, 1981;Nia et al, …”

“…Although in vitro chronotropic or inotropic effect of fluvoxamine has not been reported, in vivo negative chronotropic effect of fluvoxamine has been observed in dogs (Roos, 1983) and patients (de Wilde et al, 1983;Granfors et al, 2004;Pacher and Kecskemeti, 2004;Saletu et al, 1977), and in vivo negative inotropic effect has been shown in rabbits (Claassen, 1983;Wouters and Deiman, 1983). Meanwhile, fluvoxamine decreased the total peripheral resistance, leading to the hypotensive action.…”

Antipsychotics in the Treatment of Autism

“…Imipramine may be also useful to treat nocturnal enuresis and/or associated sleep disorder Imipramine (Lehmann et al, 1958) (Campbell et al, 1971) Clomipramine (Volmat et al, 1968) (Brodkin et al, 1997) Desipramine (Olesen, 1963) (Gordon et al, 1992) Antidepressants-SSRI The selective serotonin reuptake inhibitors (SSRI), are the most commonly prescribed antidepressants, relatively safe and generally cause fewer side effects than other types of antidepressants. They may be also be useful in the whole associated spectrum of anxiety symptoms Paroxetine (Lassen, 1978) (Posey et al, 1999) Fluoxetine (Fuller et al, 1974) (Mehlinger et al, 1990) Fluvoxamine (Saletu et al, 1977) (McDougle et al, 1990 Escitalopram (Hyttel, 1977) (Anderson et al, 2002) Antidepressant drug.…”