Fluticasone furoate nasal spray reduces the nasal-ocular reflex: A mechanism for the efficacy of topical steroids in controlling allergic eye symptoms

Are intranasal corticosteroids all equally consistent in managing ocular symptoms of seasonal allergic rhinitis?

“…INS have shown efficacy in treating the nasal symptoms of AR, and inconsistent evidence suggests that INS are also effective in treating the ocular symptoms associated with AR 16 . Furthermore, recent data suggest that ocular symptoms might be produced by a nasoocular reflex 17,18 , and that the anti-inflammatory effects of INS might reduce the initiation of this reflex, thereby decreasing ocular symptoms [19][20][21] .…”

A Pilot Study Investigating the Impact of Topical Nasal Steroid Spray in Allergic Rhinitis Patients with Dry Eye

“…Many patients with AR have ocular symptoms [12]. The use of nasal steroids has been clearly demonstrated in studies to alleviate allergic ocular symptoms [13-15]. …”

Mometasone furoate nasal spray reduces the ocular symptoms of seasonal allergic rhinitis

“…In a recent comprehensive article by Keith and Scadding, 60 several INS agents (budesonide, beclomethasone dipropionate, fluticasone furoate [FF], fluticasone propionate, MFNS, and triamcinolone acetonide) were found to have positive effects on relieving ocular symptoms of SAR, 60 and several authors have suggested that the ocular efficacy of INS agents is a class effect rather than an attribute of a single agent. 61,62 Class-based ocular effects on individual morning symptoms are less established. In 5 recent placebo-controlled studies, FF significantly improved iTOSSs.…”