A Pilot Study Investigating the Impact of Topical Nasal Steroid Spray in Allergic Rhinitis Patients with Dry Eye

Abstract

Objective: The aim of this study is to demonstrate the effect of nasal steroid treatment on intraocular pressure and dry eye in allergic rhinitis patients with dry eye. Materials and Methods: Twenty-nine patients with a diagnosis of allergic rhinitis and dry eye were included. Symptoms and findings of patients before and after nasal steroid therapy were compared. Result: Ocular Surface Disease Index scores for dry eye symptoms showed significant improvement after nasal steroid treatment (p = 0.003). In the Schirmer test, no significant change was observed in the right or left eye (p = 0.167 and p = 0.489). For the tear film break-up time, no significant change was observed in the right or left eye (p = 0.076 and (p = 0.170). No significant change was observed in the right eye or the left eye in an intraocular pressure test (p = 0.893 and p = 0.495). Conclusion: In our study, symptoms of dry eye with allergic rhinitis were significantly improved with nasal steroid therapy, without affecting the intraocular pressure.

Effect of Intranasal Corticosteroids on Intraocular Pressure and Nerve Fiber Layer Thickness: A Cross-Sectional Study at a Tertiary Care Hospital in Western Saudi Arabia

“…This study revealed that oral and eyedrop administration of corticosteroids may be more potent and harmful than nasal administration. These results, therefore, support the safety of intranasal steroids [18].…”

“…Yenigun et al [18] developed a pilot study to understand the impact of topical nasal steroids administered in patients with rhinitis and dry eyes. This study was conducted for six weeks and demonstrated that administration of nasal steroids for rhinitis significantly improved symptoms of dry eye without affecting IOP.…”

Explanatory Model of Dry Eye Disease Using Health and Nutrition Examinations: Machine Learning and Network-Based Factor Analysis From a National Survey

“…In addition, depression was serially connected to other risk factors (Figure 3), such as female sex, stress, and rhinitis, which may be utilized for DED risk evaluation and control because positively connected serial factors can occur together with possible causalities. For rhinitis, allergic rhinitis was reported to be significantly associated with DED, and inflammation is related to both [30,31]. Notably, rhinitis was a clinically reliable factor because it was diagnosed by physician's examination.…”

Recent Advances in Clinical Allergy and Immunology

“…Symptoms of dry eyes associated with allergic rhinitis improve upon intranasal corticosteroid therapy, while the intraocular pressure is not affected [28]. …”