Flussquantifizierung mit der  Magnetresonanz-Tomographie:  Eine experimentelle Studie  an einem Flussmodell und Liquor-Flussmessungen im Aquaeductus cerebri bei Probanden

Brinkmann, G.; Harlandt, O.; Mühle, Claus; Brossmann, Joachim; Heller, Martin

doi:10.1055/s-2000-9217

Cited by 10 publications

(2 citation statements)

References 10 publications

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“…30 Reliable flow quantification is reported to be feasible if the diameter of the aqueduct lumen is greater than 1.5 mm. 2 31 Zamboni et al found a net CSF flow in the cerebral aqueduct to be reduced in MS patients with CCSVI. They concluded that a significant relationship exists between the decline in net CSF flow and CCSVI severity.…”

Section: Discussionmentioning

confidence: 99%

Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis

AĞLAMIŞ

Gönen

2022

Arq Neuropsiquiatr

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Background Multiple sclerosis (MS) is usually described as an autoimmune disease, although the exact mechanism of the disease remains unknown. There have been studies reporting that venous flow abnormalities may be involved in the pathogenesis of MS or many of the associated clinical manifestations. Objective The aim of this study was to evaluate flow volumes of the middle cerebral artery (MCA), transverse sinus (TS), and cerebral aqueduct using phase contrast magnetic resonance imaging (PC-MRI) in relapsing-remitting MS patients and a control group. Methods We included 34 patients diagnosed by the McDonald criteria, revised in 2017, as well as 15 healthy controls matched by age and sex. The MRI scans were performed using a 1.5-T superconducting scanner. Axial T1-weighted, T2-weighted, and PC-MRI sequences were performed for the quantitative investigation of flow volume measurements. Quantitative analyses of flows were performed using flow analyses program PC-MRI angiography software. A circular region of interest was placed manually into the cerebral aqueduct, bilateral MCA, and TS. Results Flow volumes of the cerebral aqueduct and MCA were not statistically significant between the MS and control groups. The flow volumes of the TS for the patient group were lower than those of the control group, and this difference was statistically significant. Conclusions A reduced TS flow volume in MS patients was noted in the present study when compared with the control group, suggesting a relation between venous pathologies and MS. Further studies are needed to understand whether this relation is causal or epiphenomenal.

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Section: Discussionmentioning

confidence: 99%

Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis

AĞLAMIŞ

Gönen

2022

Arq Neuropsiquiatr

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“…In the 1990s, this method was introduced and established primarily for investigations of the brain by Quencer et al, 27 Levy et al, 17,18 and Nitz and colleagues 23 -as well as by Schroth and Klose 32 in Germany-and has been verified in several studies. 3,5,18 This method allows MR images of CSF flow to be displayed in a cine mode throughout the cardiac cycle.…”

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confidence: 99%

Standard and cardiac-gated phase-contrast magnetic resonance imaging in the clinical course of patients with Chiari malformation Type I

Mauer¹,

Gottschalk²,

Mueller³

et al. 2011

FOC

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Object The causal treatment of Chiari malformation Type I (CM-I) consists of removing the obstruction of CSF flow at the level of the foramen magnum. Cerebrospinal fluid flow can be visualized using dynamic phase-contrast MR imaging. Because there is only a paucity of studies evaluating CSF dynamics in the region of the spinal canal on the basis of preoperative and postoperative measurements, the authors investigated the clinical usefulness of cardiacgated phase-contrast MR imaging in patients with CM-I. Methods Ninety patients with CM-I underwent preoperative MR imaging of CSF pulsation. Syringomyelia was present in 59 patients and absent in 31 patients. Phase-contrast MR imaging of the entire CNS was used to investigate 22 patients with CM-I before surgery and after a mean postoperative period of 12 months (median 12 months, range 3–33 months). In addition to the dynamic studies, absolute flow velocities, the extension of the syrinx, and tonsillar descent were also measured. Results The changes in pulsation were highly significant in the region of the (enlarged) cistern (p = 0.0005). Maximum and minimum velocities (the pulsation amplitude) increased considerably in the region where the syrinx was largest in diameter. The changes of pulsation in these patients were significant in the subarachnoid space in all spinal segments but not in the syrinx itself and in the central canal. Conclusions The demonstration of CSF flow pulsation can contribute to assessments of surgical outcomes. The results presented here, however, raise doubts about current theories on the pathogenesis of syringomyelia.

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Quantitative Evaluation of Normal Aqueductal Cerebrospinal Fluid Flow Using Phase‐Contrast Cine MRI According to Age and Sex

Öner

Kahraman

Köse

et al. 2016

The Anatomical Record

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The aim of this study was cerebrospinal fluid (CSF) flow quantification in the cerebral aqueduct using phase-contrast cine magnetic resonance ımaging (PCC-MRI) according to both sexes and three different age groups to obtain normative data. Seventy two volunteers with no cerebral pathology were included in this study. Subjects were divided into three age groups: 20-34 years, 35-49 years, and 50-65 years including equal gender groups. CSF flow's quantitatively evaluation was performed with images that were obtained by 1.5 T Magnetic Resonance (MR) unit from cerebral aqueduct level on the semi-axial plan. Between groups, peak velocity (cm sec ), average velocity (cm/s), forward volume (mL), reverse volume (mL), net forward volume (mL), and average flow over range (ml/min) values of current flowing through aqueduct and average aqueductal areas were compared. There were no statistically significant differences in CSF flow parameters among different age groups and between sexes (P > 0.05). There was a statistically significant difference in average cerebral aqueduct area between the age group of 50-65 years and the other age groups (P = 0.002). The average aqueductal area was higher in the age group of 50-65 years. Normal aqueductal CSF flow parameters evaluated with PCC-MRI don't show a significant difference by age and sex. We have achieved the lower and upper values of these parameters would be useful in future clinical studies. The size of aqueductal area may also be explained by atrophy-dependent ventricular system dilatation in the elderly. Anat Rec, 300:549-555, 2017. © 2016 Wiley Periodicals, Inc.

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Flussquantifizierung mit der Magnetresonanz-Tomographie: Eine experimentelle Studie an einem Flussmodell und Liquor-Flussmessungen im Aquaeductus cerebri bei Probanden

Cited by 10 publications

References 10 publications

Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis

Flow volume measurement of arterial venous and cerebrospinal fluid in patients with multiple sclerosis

Standard and cardiac-gated phase-contrast magnetic resonance imaging in the clinical course of patients with Chiari malformation Type I

Quantitative Evaluation of Normal Aqueductal Cerebrospinal Fluid Flow Using Phase‐Contrast Cine MRI According to Age and Sex

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