Fluoxetine effects on mitochondrial ultrastructure of right ventricle in rats exposed to cold stress

Daud, Fernanda V.; Murad, Neif; Meneghini, Adriano; Ferreira, Marcelo; Ferreira, Celso; Abreu, Luíz Carlos de; Valenti, Vítor Engrácia

doi:10.1590/s0102-76382009000200013

Cited by 17 publications

(15 citation statements)

References 23 publications

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“…It is well described that sympathetic activity is increased during stress conditions [2-4,29] and SHR is also a model to study hyperactivity and stress disorders [30,31]. The imbalance between sympathetic and parasympathetic components of the baroreflex in SHR is associated to their sympathetic hyperactivity.…”

Section: Discussionmentioning

confidence: 99%

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Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats

Cisternas¹,

Valenti²,

Alves³

et al. 2010

Int Arch Med

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BackgroundThe literature did not evidence yet with which age spontaneously hypertensive rats (SHR) start to present baroreflex reduction. We endeavored to evaluate the baroreflex function in eight-week-old SHR.MethodsMale Wistar Kyoto (WKY) normotensive rats and SHR aged eight weeks were studied. Baroreflex was calculated as the variation of heart rate (HR) divided by the mean arterial pressure (MAP) variation (ΔHR/ΔMAP) tested with a depressor dose of sodium nitroprusside (SNP, 50 μg/kg) and with a pressor dose of phenylephrine (PHE, 8 μg/kg) in the right femoral venous approach through an inserted cannula in the animals. Significant differences for p < 0.05.ResultsBaseline MAP (p < 0.0001) and HR (p = 0.0028) was higher in SHR. Bradycardic peak was attenuated in SHR (p < 0.0001), baroreflex gain tested with PHE was also reduced in the SHR group (p = 0.0012). PHE-induced increase in MAP was increased in WKY compared to SHR (p = 0.039). Bradycardic reflex responses to intravenous PHE was decreased in SHR (p < 0.0001).ConclusionEight weeks old SHR already presents impairment of the parasympathetic component of baroreflex.

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Section: Discussionmentioning

confidence: 99%

“…These similarities include a genetic predisposition to high blood pressure with no specific etiology, increased total peripheral resistance without volume expansion and similar responses to drug treatment [1]. Moreover, cardiac hypertrophy, a stress model of heart disease [2-4] is another feature of SHR [5]. …”

Section: Introductionmentioning

confidence: 99%

Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats

Cisternas¹,

Valenti²,

Alves³

et al. 2010

Int Arch Med

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“…Besides cardiac hypertrophy observed in stress models and in spontaneous hypertensive rats (SHR) (Cenko et al 2004;Meneghini et al 2008;Daud et al 2009;Ferreira et al 2009;Meneghini et al 2009), baroreflex is also impaired in this strain (Valenti et al 2009a). Hence, this strain is already at a higher risk due to their baroreflex impairment (Valenti et al 2009a).…”

Section: Introductionmentioning

confidence: 99%

Effects of sidestream cigarette smoke exposure on baroreflex components in spontaneously hypertensive rats

Valenti

Abreu

Saldiva

et al. 2010

International Journal of Environmental Health Research

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We evaluated short-term effects of sidestream cigarette smoke (SSCS) exposure on baroreflex function in spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) normotensive rats. Rats were exposed to SSCS during three weeks, 180 min, five days per week, in a concentration of carbon monoxide (CO) between 100 and 300 ppm. We observed that SSCS exposure increased tachycardic peak and heart rate range while it attenuated bradycardic reflex in WKY. In respect to SHR, SSCS also increased tachycardic peak. Taken together, our data suggests that three weeks of exposure to SSCS affects the sympathetic and parasympathetic component of the baroreflex in normotensive WKY while it tended to affect the sympathetic component in SHR.

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“…Cold stress was performed only once. Rat's temperature was controlled at approximately 37°C and the behavior of the animals was observed during all the procedures [5,6,15,16]. …”

Section: Methodsmentioning

confidence: 99%

Memantine effects on liver and adrenal gland of rats exposed to cold stress

et al. 2011

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BackgroundMemantine attenuates heart stress due cold stress, however, no study focused its effects on liver and adrenal gland. We evaluated its effects on lipid depletion in adrenal gland and glycogen depletion in liver of rats exposed to cold stress.MethodsMale rats divided into 4 groups: 1)Control (CON); 2)Memantine (MEM); 3)Induced cold stress (IH) and; 4)Induced cold stress memantine (IHF). Memantine were administrated by gavage (20 mg/kg/day) during eight days. Cold stress were performed during 4 hours once at - 8°C. Lipid and glycogen depletion were presented as its intensity levels.ResultsRats exposed to cold stress presented the highest glycogen (p < 0.001) and lipid depletion (p < 0.001) in liver and adrenal gland, respectively. We noted that memantine significantly reduced lipid depletion in adrenal gland and glycogen depletion in liver.ConclusionMemantine prevented glycogen depletion in liver and lipid depletion in adrenal gland of rats under a cold stress condition.

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Fluoxetine effects on mitochondrial ultrastructure of right ventricle in rats exposed to cold stress

Abstract: Fluoxetine effects on mitochondrial ultrastructure of right ventricle in rats exposed to cold stress Efeitos da fluoxetina sobre a ultraestrutura mitocondrial no ventrículo direito de ratos expostos ao estresse pelo frio

Cited by 17 publications

References 23 publications

Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats

Cardiac baroreflex is already blunted in eight weeks old spontaneously hypertensive rats

Effects of sidestream cigarette smoke exposure on baroreflex components in spontaneously hypertensive rats

Memantine effects on liver and adrenal gland of rats exposed to cold stress

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