Fluoxetine and Fibromyalgia

Finestone, Douglas H.

doi:10.1001/jama.1990.03450220031017

Cited by 15 publications

(3 citation statements)

References 4 publications

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“…Antidepressant drugs have been widely used in the treatment of chronic pain (Butler 1984 ;Theesen & Marsh 1989 ;Finestone & Ober 1990 ;Schweyen 1990 ;Max et al 1992 ;Kharkevich & Churukanov 1999 ;Reimann et al 1999 ;Sawynok et al 1999). They may be useful even when there is no evidence of clinical depression (Feinmann 1985).…”

Section: Discussionmentioning

confidence: 99%

“…There is a well known association between chronic pain and depression, thus antidepressant drugs have been employed in the treatment of chronic pain (Walsh 1983 ;Fasmer et al 1989). Antidepressants with different effects on the reuptake of serotonin and noradrenaline have been used clinically (Feinmann 1985 ;Finestone & Ober 1990 ;Max et al 1992). In animal studies, some tricyclic antidepressants may elicit antinociceptive effects when given alone, or may potentiate the analgesic effect of opiates (Ossipov et al 1982 ;Spiegel et al 1983).…”

Section: Introductionmentioning

confidence: 99%

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Effect of chronic and acute administration of fluoxetine and its additive effect with morphine on the behavioural response in the formalin test in rats

Nayebi

Hassanpour

Rezazadeh

2001

Journal of Pharmacy and Pharmacology

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Serotonergic systems are involved in the central regulation of nociceptive sensitivity. Fluoxetine, a selective inhibitor of the reuptake of serotonin (5-hydroxytryptamine, 5-HT), was administered orally (0.16, 0.32, 0.8 mg kg(-1) daily for 7 days), intraperitoneally (0.04, 0.08, 0.16 mg kg(-1) day(-1) for 7 days and a single dose of 0.32 mg kg(-1)) and intracerebroventricularly (10 microg/rat) to rats and nociceptive sensitivity was evaluated using the formalin test (50 microL of 2.5% formalin injected subcutaneously). The effect of fluoxetine was also studied in the presence of 5,7-dihydroxytryptamine creatinine sulfate (5,7-DHT) and after co-administration with morphine. Oral (0.8 mg kg(-1)), intraperitoneal (0.16 and 0.32 mg kg(-1)) and intracerebroventricular (10 microg/rat) fluoxetine induced antinociception in the late phase of the formalin test. Furthermore, intrathecal administration of 5-HT (100 microg/rat) induced an analgesic effect. The analgesic effect of fluoxetine (0.16 and 0.32 mg kg(-1), i.p.) and 5-HT (100 microg/rat, i.t.) was abolished by pre-treatment with 5,7-DHT (100 microg/rat, i.t.). In addition, the analgesic effect of 5-HT (100 microg/rat, i.t.) was decreased by pre-treatment with naloxone (2 mg kg(-1), i.p.). Morphine (5 mg kg(-1), i.p.) induced analgesia that was increased by fluoxetine (0.32 mg kg(-1), i.p.). These results suggest that fluoxetine has an antinociceptive effect in tonic inflammatory pain through functional alteration of the serotonergic system and also potentiates the analgesic effect of morphine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of chronic and acute administration of fluoxetine and its additive effect with morphine on the behavioural response in the formalin test in rats

Nayebi

Hassanpour

Rezazadeh

2001

Journal of Pharmacy and Pharmacology

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show abstract

“…Early case studies indicated positive results secondary to fluoxetine treatment when used either alone or in combination with the TCA doxepin. 29, 30 However, the results were mixed in more recent double-blind, placebo-controlled trials. [31][32][33] One of these trials 32 compared fluoxetine and amitriptyline, alone and in combination, with placebo in 31 patients.…”

Section: Clinical Reportsmentioning

confidence: 99%