Fluorouracil As an Adjuvant to Surgery in Carcinoma of the Colon

Higgins, George A.; Dwight, Richard W.; Smith, J.; Keehn, Robert J.

doi:10.1001/archsurg.1971.01350040101020

Cited by 106 publications

(15 citation statements)

References 6 publications

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“…Many controlled studies have been conducted, mainly in the United States to investigate postoperative adjuvant chemotherapy for colorectal cancer, with several reports showing its effectiveness. [2][3][4] In 1990, Moertel et al 5 showed the efficacy of therapy with levamisole plus 5-FU, which was determined to be a standard therapy for colorectal cancer by the Meeting of of National Cancer Institute and National Institute of Health. 6 However, most of these studies used the intravenous route.…”

Section: Discussionmentioning

confidence: 99%

Effect of oral adjuvant therapy with Carmofur (HCFU) for distant metastasis of colorectal cancer

Ito

Yamaguchi

Miura

et al. 2000

International Journal of Clinical Oncology

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Background. The effectiveness of adjuvant chemotherapy for colorectal cancers after curative resection has been reported recently; this study was performed to clarify the reasons of for this effectiveness, which have been unclear. Methods. Two joint prospective clinical randomized studies were performed. In the first study, of patients operated on between July 1, 1981 and June 30, 1983, at 41 Centers in the Tokai district, 172 patients with colorectal cancer were allocated to two groups. In the control group, mitomycin C (MMC) was given eight times intravenously in the 4 weeks after surgery. The other group, in addition to receiving the same regimen as the controls, received oral administration of 1-hexylcarbamoyl-5-fluorouracil (HCFU) at 600 mg/day for at least 6 months after the 4-week MMC treatment. In the second study of patients operated at 7 Centers in the Tokai district between October 1, 1987 and September 30, 1990, 173 patients with colorectal cancer were allocated to two groups after surgery, a control group receiving no HCFU, the other group receiving HCFU at 0.8 mg/kg per day orally, for 1 year, beginning 4 weeks after the operation. Results. In the first study, the cumulative 10-year survival rate of the MMC + HCFU group was higher than that of the MMC-alone group (P < 0.05). In the second study, the cumulative 5-year disease-free survival rate of the HCFU group was higher than that of the control group (surgery alone; P < 0.05). In patients with colon cancers, the rate of distant metastases for all evaluable patients was lower in the MMC + HCFU group than in the MMC-alone group in the first study (P < 0.05), and the rate was lower in the HCFU group than in the surgery-alone group in the second study (P < 0.02). Conclusion. The effectiveness of HCFU in reducing the disease-free survival rate appeared to be mainly due to its preventive effect on distant metastases.

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Section: Discussionmentioning

confidence: 99%

Effect of oral adjuvant therapy with Carmofur (HCFU) for distant metastasis of colorectal cancer

Ito

Yamaguchi

Miura

et al. 2000

International Journal of Clinical Oncology

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“…These studies [21][22][23] in which Cole was again the instrumental leader, helped to make many surgeons familiar with chemotherapy and laid the foundations for surgical co-operative group studies, but evidence for a thera peutic effect was lacking. Only in one group of breast cancer patients (preme nopausal, with 4 or more positive axillary nodes) was a definite retardation of recurrence observed [24], Recent adjuvant studies, in which chemotherapy is continued until recurrence, rather than being stopped after one course, are more promising, and may show the way to significant improvement in surgi cal patients with a poor prognosis [25]. One of the more provocative reports is that of Rousselot and associates [26] who reported, in 1968, that the use of 5-fluorouracil injected intraluminally in patients with colorectal cancer had led to a 5-year salvage rate in stage III lesions of 65%, as opposed to 32% in the control group.…”

Section: Adjuvant Chemotherapymentioning

confidence: 99%

Contributions of Surgeons to Clinical Cancer Chemotherapy

Wb¹

1972

Oncology

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“…A large number of studies have been carried out on wound healing using 5-FU. The results varied from study to study depending upon the methodology used [1][2][3][4] . Mitomycin (MMC), on the other hand, is an alkylating agent which causes inhibition of DNA synthesis by alkylating DNA resulting in intrastrand and interstrand crosslinks.…”

Section: Introductionmentioning

confidence: 99%

Effect of 5-Fluorouracil and Mitomycin on the Healing of Intestinal Anastomosis

Shukla

Pandey²,

Das³

et al. 2007

Chemotherapy

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Objective: Antineoplastic agents affect the healing of intestinal anastomosis. The aim was to evaluate the effect of 5-fluorouracil (5-FU) and mitomycin on the healing of the intestinal anastomosis and their schedule of administration. Material and Methods: Eighty-nine male albino Charles Foster rats with a mean weight of 256.57 g were divided into six groups. Group A represents the control, while in others varying schedules of chemotherapy (5-FU and mitomycin) were administered. The sacrifices were made on days 7, 14 and 21 postoperatively and bursting pressure and hydroxyproline content were measured. Results: Nine rats died before completion of the experiment and were excluded. Adhesions were noted in all rats on sacrifice. The mean bursting pressure of normal intestine (group A) was 252 mm Hg. The bursting pressure was lower on day 7 (208 mm Hg) and it subsequently increased by day 21 (230 mm Hg). The mean bursting pressure in groups B, C, D and E was 174, 194, 182 and 188 mm Hg and it subsequently increased to 232, 272, 244 and 286 mm Hg. There was no difference in the pattern of bursting pressure in colon and ileum. The mean hydroxyproline content of ileum (group A) on day 7 was 34.37 mg/g tissue. The hydroxyproline content of the ileum in groups B, C, D and E was 15.08, 27.03, 7.75 and 21.04 mg/g tissue. There was a significant decrease in hydroxyproline content following anastomosis and chemotherapy. Conclusions: The effect of chemotherapy was pronounced when administered on the day of surgery or in the immediate pre- or postoperative period. Hence administration of chemotherapy during this period may be harmful.

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Fluorouracil As an Adjuvant to Surgery in Carcinoma of the Colon

Cited by 106 publications

References 6 publications

Effect of oral adjuvant therapy with Carmofur (HCFU) for distant metastasis of colorectal cancer

Effect of oral adjuvant therapy with Carmofur (HCFU) for distant metastasis of colorectal cancer

Contributions of Surgeons to Clinical Cancer Chemotherapy

Effect of 5-Fluorouracil and Mitomycin on the Healing of Intestinal Anastomosis

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