Fluorosilicone oil in the treatment of retinal detachment.

Gremillion, Charles M.; Peyman, Gholam A.; Liu, Kwan-Rong; Naguib, K. S.

doi:10.1136/bjo.74.11.643

Cited by 55 publications

(22 citation statements)

References 12 publications

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“…The present data confirm other observa tions on the absence of toxicity of this com pound on the retina [7][8][9]11 ], as well as simi lar observations of lack of toxicity on the cor neal endothelium [4], The latter observation is of importance because comparisons of other toxic compounds on both corneal endo thelium and blood-retinal barrier have indi cated that the corneal endothelium is the more sensitive paradigm for toxicity evalua tion of such materials [4,[17][18][19][20] vitreous at a substantial volume (25% of the total capacity of the vitreous cavity), offers no overt toxic effects on the blood-retinal bar rier, albeit the rabbit retinal vasculature is not the same as that of a human eye. Prior studies on retinal toxicity of perfluoro-n-octane indi cated that even large quantities of this liquid (80-90% replacement of vitreous volume) caused no change in the electroretinogram, although some histopathological changes were indicated where the liquid contacted the retina [11],…”

Section: Discussionsupporting

confidence: 82%

“…Previous studies with perfluoro-n-octane in the rabbit anterior chamber revealed that no toxicity occurred to the corneal endothelium following the re placement of about one quarter of the ante-rior volume with the liquid [4], On the other hand, another report on complete replace ment of the aqueous humor with fluid [5] indicated that corneal swelling without a change in corneal clarity occurred within the first 24 h of exposure. Some perfluorocarbon derivatives have been shown, however, to cause retinal toxicity [6] although fluorosilicone oil has been reported not to induce reti nal toxicity [7][8][9], as has perfluorophenanthrene [10]. Perfluoro-n-octane has also been reported to have great ocular tolerance for up to 6 months in rabbit eyes as judged by electroretinography.…”

Section: Introductionmentioning

confidence: 99%

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Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

Green

Slagle²,

Chaknis³

et al. 1993

Ophthalmic Res

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Studies have been made of the effects of intravitreal perfluoro-n-octane on the permeability to fluorescein of the blood-retinal barrier in rabbits. At day 1 after injection, there is increased aqueous humor fluorescence that reflects the physical disturbance to the eye following injection. From that time through 7 weeks, there is no evidence of any overt toxicity to the blood-retinal barrier. The retention in the vitreous of a small volume of perfluoro-n-octane following its intraoperative use would not be expected to induce a toxic response. Some effect on an already compromised retina cannot, however, be excluded.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

Green

Slagle²,

Chaknis³

et al. 1993

Ophthalmic Res

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“…So far no randomized clinical trial on the efficacy of heavier than water endotamponades exists for retinal detachments with inferior tears and inferior PVR. The success rate is lying between 50% (FsiO/silicone oil mixture [19]), 77% (fluorosilicone oil [21]), 78% (F 6 H 8 [7]), 86% (F 6 H 8 [22]) and 100% (perfluoroperhydrophenanthrene [23]). This wide discrepancy is mainly due to the fact that many authors assume as end-point criteria partial retinal reattachment, including eyes with endotamponade still filling the vitreous chamber.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

Rizzo

Genovesi-Ebert²,

Belting³

et al. 2005

Ophthalmologica

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Aim: To report on the use of a combined intra-ocular tamponade with silicone oil and perfluorohexyloctane (F₆H₈) in the treatment of complex retinal detachment. Design: A prospective consecutive interventional case series from seven study centres. Participants: 69 patients presenting a retinal detachment with proliferative vitreoretinopathy (PVR) and retinal breaks of the inferior two quadrants of the fundus. Method: Patients were divided into two groups: (1) 28 eyes which had not been operated on before; (2) 41 eyes affected by recurrent retinal detachment that had had unsuccessful previous surgery with silicone oil or gas tamponade. A pars plana vitrectomy, membrane peeling and – when necessary – a retinotomy were performed; the vitreous cavity was filled with two thirds of F₆H₈ and one third of silicone oil 1,000 mPas (double filling, DF). The endotamponade was removed after 30–45 days (median 38) and replaced by balanced salt solution or silicone oil according to the condition of the retina. Results: Retinal reattachment was achieved in 52 out of 69 cases (75%) 6 months after removal of the DF without any endotamponade. Conclusion: The DF with F₆H₈ and silicone oil allows a good endotamponading to the inferior retina and the posterior pole. The DF appeared to be well tolerated. Further studies are necessary to evaluate whether a DF is advantageous in respect to silicone oil filling alone in case of retinal breaks and PVR of the inferior retina.

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“…Recently, florosilicone oil (FSiO; heavier than water) has been proposed as extended internal tamponade [10][11][12]. The FSiO bubble creates a free space located in the upper part of the vitreous chamber and delimited by the silicone bubble itself and the superior retina.…”

Section: Introductionmentioning

confidence: 99%

Combined Silicone and Fluorosilicone Oil Tamponade (Double Filling) in the Management of Complicated Retinal Detachment

Bottoni

Arpa²,

Vinciguerra

et al. 1992

Ophthalmologica

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We evaluated the use of simultaneous double filling with polydimethylsiloxane (PDMS) and fluorosilicone (FSiO) in the repair of complicated retinal detachment in 12 selected cases. Initial retinal reattachment was achieved in all cases. Proliferative vitreoretinopathy (PVR) recurred in 10 patients (83%) 6 of which showed partial retinal detachment. Inferior and superior postoperative residual free spaces were abolished by this procedure, but a new residual fluid space was created, lying horizontally between the bubbles and expanding in a triangular shape nasally to the optic disk and temporally to the macula. Overall, 9 of 10 eyes with postoperative PVR had proliferation involving these areas. These findings support the concept that ‘compartmentalization’ is of major importance in determining postoperative cell proliferation.

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Fluorosilicone oil in the treatment of retinal detachment.

Abstract: We evaluated the use of a heavier-than-water fluorinated silicone oil in the treatment of 30 selected cases of complicated retinal detachment from

Cited by 55 publications

References 12 publications

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

Perfluorocarbon Effects on Rabbit Blood-Retinal Barrier Permeability

Long-Term Vitreous Replacement with Perfluorohexyloctane and Silicone Oil: Preliminary Reports of a Multicentric Study

Combined Silicone and Fluorosilicone Oil Tamponade (Double Filling) in the Management of Complicated Retinal Detachment

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