Fluoroquinolones and Tendinopathy: A Guide for Athletes and Sports Clinicians and a Systematic Review of the Literature

Lewis, Trevor; Cook, Jillianne Leigh

doi:10.4085/1062-6050-49.2.09

Cited by 87 publications

(86 citation statements)

References 43 publications

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“…22 The mechanism of action 23 involves the inhibition of bacterial DNA topoisomerase II (gyrase) and topoisomerase IV, which are enzymes involved in untwining bacterial DNA during the replication process. Regrettably, CIP has also been shown to decrease the viability of eukaryotic cells, leading to multiple adverse effects 24,25 , such as tendinopathies 26 and peripheral neuropathy 27,28 , due to a decline in the synthesis of proteins encoded in mitochondrial deoxyribonucleic acid (mtDNA). Analysis of mtDNA from CIP-treated cells revealed the presence of site-specific, double-stranded DNA breaks 29 , which were attributed to inhibition of mitochondrial topoisomerase II activity, functionally and structurally similar to that found in bacteria.…”

Section: Discussionmentioning

confidence: 99%

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

Kamocki

Bottino

2015

Archives of Oral Biology

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Objective A combination of antibiotics, including but not limited to metronidazole (MET) and ciprofloxacin (CIP), has been indicated to eradicate bacteria in necrotic immature permanent teeth prior to regenerative procedures. It has been shown clinically that antibiotic pastes may lead to substantial stem cell death. The aim of this study was to synthesize scaffolds containing various concentrations of CIP to enhance cell viability while preserving antimicrobial properties. Design Polydioxanone (PDS)-based electrospun scaffolds were processed with decreasing CIP concentrations (25 – 1 wt.%) and morphologically evaluated using scanning electron microscopy (SEM). Cytotoxicity assays were performed to determine whether the amount of CIP released from the scaffolds would lead to human dental pulp stem cell (hDPSC) toxicity. Similarly, WST-1 assays were performed to evaluate the impact of CIP release on hDPSC proliferation. Pure PDS scaffolds and saturated double antibiotic solution MET/CIP (DAP) served as both positive and negative controls, respectively. Antibacterial efficacy against E. faecalis (Ef) was tested. Results A significant decrease in hDPSC’ viability at concentrations 5–25 wt.% was observed. However, concentrations below 5 wt.% did not impair cell viability. Data from the WST-1 assays indicated no detrimental impact on cell proliferation for scaffolds containing 2.5 wt.% CIP or less. Significant antimicrobial properties were seen for CIP-scaffolds at lower concentrations (i.e., 1 and 2.5 wt.%). Conclusion The obtained data demonstrated that a reduced concentration of CIP incorporated into PDS-based scaffolds maintains its antimicrobial properties while enhancing viability and proliferation of dental pulp stem cells.

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Section: Discussionmentioning

confidence: 99%

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

Kamocki

Bottino

2015

Archives of Oral Biology

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“…В амбулаторной практике основное значение имеет потенциальная нейротоксичность фторхи-нолонов. Индикатор просудорожной активности, характе-ризующий возбуждающее действие на ЦНС, существует вo всех поколениях этих антибиотиков и проявляется голов-ной болью, головокружением и сонливостью [27]. Одним из наиболее опасных побочных эффектов, связанных с приемом препаратов этой группы, является нарушение ритма, в том числе развитие желудочковых аритмий, а уд-линение интервала QT в настоящее время рассматривается как групповое свойство фторхинолонов [24].…”

Section: © коллектив авторов 2016unclassified

“…Одним из наиболее опасных побочных эффектов, связанных с приемом препаратов этой группы, является нарушение ритма, в том числе развитие желудочковых аритмий, а уд-линение интервала QT в настоящее время рассматривается как групповое свойство фторхинолонов [24]. Еще одним отличительным свойством препаратов этой группы являет-ся развитие в любом возрасте тендинита и возникновение риска разрыва сухожилия, чаще всего ахиллова, что огра-ничивает их применение в пожилом возрасте [27]. Кроме того, фторхинолоны противопоказаны при беременности, кормлении грудью, детям и подросткам до 18 лет.…”

Section: © коллектив авторов 2016unclassified

A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis

Савлевич

Козлов

Zharkykh

2016

Vestn. otorinolaringol.

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2 1 кафедра оториноларингологии (зав. -проф. в.С. козлов) ФГБу ДПо «Центральная государственная медицинская академия» управления делами Президента РФ (ректор е.в. есин), Москва, Россия, 121359; 2 ФГБу «Поликлиника №5» управления делами Президента РФ (глав. врач -д.м.н. е.Б. Александрова) Москва, Россия, 119121Острый риносинусит занимает лидирующее положение по частоте назначения антибиотиков во всем мире. Одновре-менно актуальность проблемы антибиотикорезистентности и безопасности применения антибактериальных препаратов приобретает межнациональные масштабы. В статье приведены основные механизмы устойчивости бактерий и развития побочных явлений при применении макролидов, респираторных фторхинолонов и разных классов β-лактамных анти-биотиков. Формирование IgE-опосредованной аллергии на цефалоспорины связано с боковой R 1 цепью. Строение R 1 имеет сходство с пенициллинами только у цефалоспоринов I и II поколений, тем самым создавая условия для развития перекрестной аллергии. у цефалоспоринов III и IV поколений R 1 представлена качественно другим химическим соеди-нением (аминотиазол-оксим группой), что повышает уровень толерантности к этим классам антибиотиков. Приведены данные наблюдательного исследования по оценке эффективности и безопасности нового препарата спектрацеф, дей-ствующим веществом которого является цефалоспорин III поколения цефдиторен, при лечении острого бактериального риносинусита в амбулаторной практике.

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“…Symptoms may occur hours after started therapy and even after few months after the end of administration. Recovery is significantly slower than after common injury [35]. Similarly doxycycline antibiotics inhibit collagen proteases and reduce mechanical properties of tissue, while on the other hand insulin, estrogen and testosterone -increase collagen production [49,57].…”

Section: Ageing Of the Tendonsmentioning

confidence: 99%

Tendon — function-related structure, simple healing process and mysterious ageing

Zabrzyński¹,

Łapaj

Paczesny³

et al. 2018

Folia Morphol

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Tendons are connective tissue structures of paramount importance to human ability of locomotion. The understanding of their physiology and pathology is gaining importance as advances in regenerative medicine are being made today. So far, very few studies were conducted to extend the knowledge about pathology, healing response and management of tendon lesions.In this paper we summarize actual knowledge on structure, process of healing and ageing of the tendons. The structure of tendon is optimized for the best performance of the tissue. Despite the simplicity of the healing response, numerous studies showed, that the problems with full recovery are common and much more significant than we thought, that is why we discussed the issue of immobilization and mechanical stimulation during healing process. The phenomenon of tendons' ageing is poorly understood, although it seems to be a natural and painless process, it is completely different to degeneration in tendinopathy. Recent studies of biological treatment reported faster and optimal healing of the tendons when augmented by growth factors and stem cells. Despite advances in biology of tendons, management of their injuries is still a challenge for physicians, therefore further studies are required to improve treatment outcomes.

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Fluoroquinolones and Tendinopathy: A Guide for Athletes and Sports Clinicians and a Systematic Review of the Literature

Cited by 87 publications

References 43 publications

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

Effects of ciprofloxacin-containing antimicrobial scaffolds on dental pulp stem cell viability—In vitro studies

A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis

Tendon — function-related structure, simple healing process and mysterious ageing

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