A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis

Acute rhinosinusitis is one of the most common diseases in the world. According to statistics, about 10 million cases are registered in Russia every year.Acute bacterial rhinosinusitis (ABRS) in most cases develops as a result of an acute respiratory viral disease, proceeds easily and it does not require antibiotic therapy. However, it significantly reduces the patient's quality of life in cases of moderate and severe disease, and in the absence of timely treatment, can lead to intracranial complications (meningitis, encephalitis, intracranial abscesses, etc.) and orbital (reactive edema of the eyelid, phlegmon of the orbit, periorbital abscesses, etc.). To avoid complications, with exacerbation of rhinosinusitis, it is necessary to choose the right antibiotic therapy, taking into account the resistance of the microorganisms that caused the disease.The article describes the differential diagnosticprinciples of bacterial rhinosinusitis according to the latest recommendations and research in this area, the most common antibiotic-resistant pathogens in the practice of an ENT doctor are presented, the issue of choosing the correct systemic antibiotic therapy for the treatment of patients with moderate and severe acute bacterial rhinosinusitis is considered according to modern data on the sensitivity of bacterial pathogens to antibacterial drugs prescribed in the otorhinolaryngologist's practice. The article presents data on a new universal cephalosporin of the 3rd generation (the active ingredient is cefditoren), as a second- and third-line drug, due to its high activity against most causative agents of acute bacterial rhinosinusitis, and clinical observation using the above antibacterial agent within the framework of the considered topics.

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Ceftriaxone induced fixed drug eruption in patient with common variable immunodeficiency

Shubina

Myasnikova

Фролов

et al. 2022

Russian Journal of Allergy

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Adverse drug reactions are one of the most complex and difficult diagnostic problems in practice of allergists and clinical immunologists. This article presents a clinical case of a patient with inborn error of immunity, known as common variable immune deficiency with the debut of the disease in adulthood and the presence of numerous infectious, structural, and immune complications. The patient had an adverse drug reaction representive by fixed drug eruption to the vital antibiotic therapy with ceftriaxone. We provide detailed information about this type of drug allergy, structural features of cephalosporins and their cross-reactivity. In the diagnostic process, we ran phased drug allergy testing: patch tests and a dose provocative test, wich is considered as a gold standard for this type of diagnostics. According to the test results the diagnosis of fixed drug eruption to ceftriaxone and the absence of cross-reactivity to other cephalosporins in this patient was confirmed. The compiled individual recommendations made it possible to prohibit the use of only one drug (ceftriaxone), which is especially important for a patient with primary immunodeficiency.

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A study of the efficacy and safety of new cephalosporin in the treatment of acute bacterial rhinosinusitis

Cited by 3 publications

References 27 publications

Analysis of current diagnostic and treatment approaches for acute rhinosinusitis according polyclinics data of the outpatient service of Administrative Directorate of the President of the Russian Federation

Analysis of current diagnostic and treatment approaches for acute rhinosinusitis according polyclinics data of the outpatient service of Administrative Directorate of the President of the Russian Federation

Systemic antibiotic therapy of patients with acute bacterial sinusitis taking into account resistance

Ceftriaxone induced fixed drug eruption in patient with common variable immunodeficiency

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