Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE)

Shi, Jie; Deng, Qianchun; Wan, Cao; Zheng, Mingming; Huang, Fenghong; Tang, Bo

doi:10.1039/c7sc02189e

Cited by 85 publications

(32 citation statements)

References 37 publications

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“…In 2017, utilizing the heterogeneous catalytic character of lipase, Tang and coworkers developed a “turn‐on” AIE probe 89 by attaching two glutamate moieties to the TPE core. [ 216 ] The TPE core of 89 tended to insert into the oil layer, while two glutamine units of 89 could be inserted into the water layer, ensuring that 89 was distributed at the oil‐water interface, and that the glutamine group contacting lipase was fully in the aqueous phase. Accordingly, two glutamate groups on the probe were cleaved with high efficiency, releasing an insoluble product in the solution and emitting a strong blue fluorescence.…”

Section: Aiegens For Recognition Of Enzymesmentioning

confidence: 99%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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Activity‐based approaches for designing AIEgens possess prominent advantages including high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention in recent years. Excellent activatable AIE probes have been reported for detecting toxic substances, imaging intracellular active molecules/biomolecules, as well as monitoring the activity of overexpressed enzymes in cancers. Moreover, the majority of activatable theranostic AIEgens can be specifically triggered in cancer cells and can kill these cells under light irradiation, while they have no distinct effect on normal cells, demonstrating satisfactory therapeutic selectivity that is superior to that of traditional chemotherapy. Thus, in this review, we systematically summarized the development of activatable AIE bioprobes in recent years from molecular design principles to biological applications. The challenges of activatable AIE probes and the corresponding solutions are described. We hope that the information provided in this review will facilitate the design of more activatable AIE probes to promote practical application of corresponding AIEgens.

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Section: Aiegens For Recognition Of Enzymesmentioning

confidence: 99%

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

et al. 2021

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“…It is urgent to develop a stable and efficient probe for sensing lipase levels. Tang et al [47] constructed a novel light-up AIE bioprobe S1 for sensing the lipase. It is well known that lipase is capable of achieving optimal catalytic performance at the oil-water interface and is an enzyme for heterogeneous catalysis.…”

Section: Ester Bondmentioning

confidence: 99%

Analyte-responsive fluorescent probes with AIE characteristic based on the change of covalent bond

Wang

et al. 2019

Sci. China Mater.

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It is important for the determination of biologically and/or environmentally relevant species by utilization of fluorescent probes. Conventional fluorescent probes are subjected to the influence of aggregation-caused quenching that is limiting their application due to low selectivity as well as photobleaching. Additionally, quencher pairs are usually introduced in the design of these probes, which lead to the complex synthetic procedure. A novel class of fluorogens with aggregation-induced emission (AIE) characteristic provide a solution to address the dilemma. By taking advantage of the unique characteristic of AIE fluorogens, specific turn-on probes have been developed via combination with recognition components, exhibiting low background, good selectivity and outstanding photostability. This review focuses on the development of fluorescent probes with AIE characteristics via the bond cleavage as well as formation strategy.

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“…Thus, many fluorophores have been designed for the early-stage diagnosis of cancer. 6 The development of fluorescence bioprobes, such as fluorescent polymers, 7,8 inorganic nanoparticles, 9 organic dyes, [10][11][12] and quantum dots (QDs), 13 which provide alternatives for cell imaging and tracing, has recently attracted a great deal of research attention.…”

Section: Introductionmentioning

confidence: 99%

Redox-responsive fluorescent AIE bioconjugate with aggregation enhanced retention features for targeted imaging reinforcement and selective suppression of cancer cells

Yang

Fang

et al. 2019

Mater. Chem. Front.

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Fluorometric probing of the lipase level as acute pancreatitis biomarkers based on interfacially controlled aggregation-induced emission (AIE)

Abstract: We demonstrate a sensitive, easy and fast method for the fluorometric probing of the lipase level as acute pancreatitis biomarkers based on the novel interfacially controlled aggregation-induced emission (AIE) mechanism.

Cited by 85 publications

References 37 publications

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

Analyte-responsive fluorescent probes with AIE characteristic based on the change of covalent bond

Redox-responsive fluorescent AIE bioconjugate with aggregation enhanced retention features for targeted imaging reinforcement and selective suppression of cancer cells

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