Analyte-responsive fluorescent probes with AIE characteristic based on the change of covalent bond

Xu, Min; Wang, Xudong; Wang, Quan; Hu, Qinyu; Huang, Kaixun; Lou, Xiaoding; Xia, Fan

doi:10.1007/s40843-019-9407-9

Cited by 22 publications

(14 citation statements)

References 71 publications

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“…Based on the above results, Tang, Ding and co-workers thus put forward a concept of "intramolecular motion-induced photothermy (iMIPT)" as a new molecular guideline to develop advanced photothermal agents. Contrary to the "aggregation-induced emission" (AIE) process, which suppresses active intramolecular motion to emit bright light in the aggregates [93][94][95][96][97][98][99][100], iMIPT process favors the active excited-state intramolecular motion to generate heat in aggregates ( Fig. 9).…”

Section: Intramolecular Motion-induced Photothermymentioning

confidence: 99%

Organic/polymer photothermal nanoagents for photoacoustic imaging and photothermal therapy in vivo

Chen

et al. 2019

Sci. China Mater.

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In recent years, organic/polymer photothermal nanoagents including semiconducting polymer nanoparticles and small-molecule organic photothermal agents-encapsulated nanoparticles have attracted large attention from researchers in the biomedical field, owing to their excellent optical properties, good biocompatibility, easy processability, and flexible surface functionalization, as well as their combined functions of photoacoustic (PA) imaging and photothermal therapy (PTT). In this review, we summarize the recent advances in organic/ polymer photothermal nanoagents for in vivo PA imaging and PTT applications. In particular, we focus on the design strategies, which are composed of traditional approaches and emerging mechanisms, especially based on "intramolecular motion-induced photothermy" strategy to regulate the photophysical properties of organic/polymer photothermal nanoagents for boosted in vivo PA imaging and PTT.

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Section: Intramolecular Motion-induced Photothermymentioning

confidence: 99%

Organic/polymer photothermal nanoagents for photoacoustic imaging and photothermal therapy in vivo

Chen

et al. 2019

Sci. China Mater.

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“…By contrast, aggregation-induced emission PSs (AIE-PSs) emit weak light in molecular species, but shine up upon aggregation due to the restriction of intramolecular motions which suppresses nonradiative decay and results in high ROS generation [11,12,[15][16][17]. Since the first discovery of AIE phenomenon in 2001 [18], AIE-PSs have been successfully applied in the cell [12,[19][20][21][22][23][24][25][26] and bacteria imaging and ablation [4, [27][28][29][30][31][32][33][34][35][36][37][38]. In addition to the membrane-anchoring AIE-PS reported in 2019 that killed 99.9% (3.0 log 10 ) of Staphylococcus aureus (S. aureus) at a concentration of 2 µmol L −1 and 99.9% of E. coli at 5 µmol L −1 [39], most reported antibacterial rates of AIE-PSs did not exceed 99% (2.0 log 10 ).…”

Section: Introductionmentioning

confidence: 99%

A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy

et al. 2021

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Photodynamic therapy (PDT) has been drawing more and more attention in the antibacterial field. Traditional photosensitizers (PSs) tend to aggregate in aqueous media, which reduces the generation of reactive oxygen species (ROS) and seriously affects the photodynamic efficacy. Many efforts have been made to prevent aggregation of traditional PSs. By contrast, aggregation-induced emission PSs (AIE-PSs) take advantage of aggregation to boost ROS generation and fluorescence intensity. However, the efficacies of the reported antibacterial AIE-PSs are poor. Herein, we report a new class of highly effective antibacterial AIE-PSs based on nitrobenzoic acid structure. TTVBA, a negatively charged AIE-PS, can not only selectively kill spherical bacteria (Staphylococcus aureus (S. aureus)) rather than rod-shaped bacteria (Escherichia coli (E. coli)), but also be easily extended to several AIE-PSs (TTVBP1-3) with positive charges and broad-spectrum antibacterial activity. We demonstrate that TTVBP2 can kill 3.0 log 10 of S. aureus at very low concentration (125 nmol L −1 ), TTVBP3 can kill 4.7 log 10 of Staphylococcus epidermidis (S. epidermidis) at a concentration of 1 µmol L −1 and 3.8 log 10 of E. coli at 5 µmol L −1 , thus enabling them among the most effective antibacterial AIE-PSs reported so far. Meanwhile, these AIE-PSs exhibit excellent wash-free imaging ability for bacteria by simple mixing with bacteria. We thus envision that TTVBA, a nitrobenzoic acid-based extendable AIE-PS, provides a new route for the design of AIE-PSs in antibacterial treatment.

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“…The inherent and distinct properties of AIEgens provide a potential opportunity to explore a new class of PSs to overcome the aforementioned obstacles. PSs with AIE characteristic (AIEgen PSs) often show bright enhanced fluorescence emission as well as retain the 1 O 2 generation capacity in the aggregate state because of the low nonradiative decay and enhanced fluorescence in the solid or aggregate state of AIE molecules, making AIE PSs a superb possibility for image-guided PDT [37,[43][44][45][46][47][48]. An efficient intersystem crossing (ISC) rate (K ISC ) from the lowest excited state (S 1 ) to the lowest triplet state (T 1 ) increased the 1 O 2 production ability of PS, and large spin-orbit coupling (SOC) as well as a small ∆E ST (the energy gap between singlet and triplet states) could enhance K ISC [49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

Self-assembled nanostructured photosensitizer with aggregation-induced emission for enhanced photodynamic anticancer therapy

et al. 2019

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Three nanostructured photosensitizers with aggregation-induced emission (AIE) characteristics based on 2,3-bis(4ʹ-(diphenylamino)-[1,1ʹ-biphenyl]-4-yl) fumaronitrile (BDBF) were prepared for image-guided photodynamic therapy (PDT). BDBF was encapsulated with Pluronic F-127 (F127) to form usual spherical nanoparticles (F127@BDBF NPs) with a red fluorescence emission and 9.8% fluorescence quantum yield (FQY). Moreover, BDBF self-assembled into nanorods (BDBF NRs) in water. Compared with F127@BDBF NPs, BDBF NRs exhibited stronger orange fluorescence with a higher FQY of 23.3% and similar singlet oxygen (1 O 2) generation capability. BDBF NRs were further modified with F127 to form BDBF@F127 NRs with the same 1 O 2 generation ability as BDBF NRs. The three nanostructures exhibited a higher 1 O 2 production capacity than BDBF molecule in dissolved state and favorable stability in an aqueous solution as well as under physiological condition. In vitro photocytotoxicity experiments indicated that the three nanostructures inhibited tumor cell proliferation effectively. Therefore, to construct eligible nanostructures with a high FQY and 1 O 2 generation ability, simple self-assembly can serve as a valuable method to prepare photosensitizers with enhanced PDT.

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Analyte-responsive fluorescent probes with AIE characteristic based on the change of covalent bond

Cited by 22 publications

References 71 publications

Organic/polymer photothermal nanoagents for photoacoustic imaging and photothermal therapy in vivo

Organic/polymer photothermal nanoagents for photoacoustic imaging and photothermal therapy in vivo

A new class of nitrobenzoic acid-based AIE photosensitizers for highly efficient photodynamic antibacterial therapy

Self-assembled nanostructured photosensitizer with aggregation-induced emission for enhanced photodynamic anticancer therapy

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