Fluoromethcathinone, a new substance of abuse

Archer, Roland

doi:10.1016/j.forsciint.2008.11.013

Cited by 116 publications

(119 citation statements)

References 10 publications

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“…Products labelled with the same name showed 185 undistinguishable IR spectra. IR spectra of 4-FMC, 4-MEC, methedrone and 3,4M a n u s c r i p t 9 DMMC have been previously published [10][11][12][13]. Unexpected change in colour was observed in different extent on the products after X-312…”

Section: Chemical Analysis 171mentioning

confidence: 99%

Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal

Zancajo

Brito

Carrasco

et al. 2014

Forensic Science International

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Section: Chemical Analysis 171mentioning

confidence: 99%

Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal

Zancajo

Brito

Carrasco

et al. 2014

Forensic Science International

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“…Since they are mainly synthetic in origin, beta-keto amphetamines are also known as 'bk designer drugs'. It is relatively easy to produce mephedrone in nonprofessional laboratories via bromination of 4-methylpropiophenone followed by reaction with methylamine or by oxidation of 4-methylephedrine (Archer, 2009;Europol-EMCDDA, 2010).…”

Section: Chemistrymentioning

confidence: 99%

Mephedrone-Related Fatalities in the United Kingdom: Contextual, Clinical and Practical Issues

Corkery¹,

Schifano²,

Ghodse³

2012

Pharmacology

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“…Exactly when these derivatives gained popularity amongst club goers and others seeking new drugs of abuse is difficult to pinpoint, but mentions in Internet drug forums began in 2007 [11]. Synthetic cathinones that have been found in these products include butylone, dimethylcathinone, ethcathinone, ethylone, 3 and 4-fluoromethcathinone, mephedrone, methedrone, MDPV, methylone, and pyrovalerone (see Table 1 [6,[12][13][14]). …”

Section: Introductionmentioning

confidence: 99%

The Toxicology of Bath Salts: A Review of Synthetic Cathinones

2011

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Synthetic cathinones have recently emerged and grown to be popular drugs of abuse. Their dramatic increase has resulted in part from sensationalized media attention as well as widespread availability on the Internet. They are often considered "legal highs" and sold as "bath salts" or "plant food" and labeled "not for human consumption" to circumvent drug abuse legislation. Cathinone is a naturally occurring beta-ketone amphetamine analogue found in the leaves of the Catha edulis plant. Synthetic cathinones are derivatives of this compound. Those that are being used as drugs of abuse include butylone, dimethylcathinone, ethcathinone, ethylone, 3-and 4-fluoromethcathinone, mephedrone, methedrone, methylenedioxypyrovalerone (MDPV), methylone, and pyrovalerone. Synthetic cathinones are phenylalkylamines derivatives, and are often termed "bk-amphetamines" for the beta-ketone moiety. They may possess both amphetaminelike properties and the ability to modulate serotonin, causing distinct psychoactive effects. Desired effects reported by users of synthetic cathinones include increased energy, empathy, openness, and increased libido. Cardiac, psychiatric, and neurological signs and symptoms are the most common adverse effects reported in synthetic cathinone users who require medical care. Deaths associated with use of these compounds have been reported. Exposure to and use of synthetic cathinones are becoming increasingly popular despite a lack of scientific research and understanding of the potential harms of these substances. The clinical similarities to amphetamines and MDMA specifically are predictable based on the chemical structure of this class of agents. More work is necessary to understand the mechanisms of action, toxicokinetics, toxicodynamics, metabolism, clinical and psychological effects as well as the potential for addiction and withdrawal of these agents.

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Fluoromethcathinone, a new substance of abuse

Cited by 116 publications

References 10 publications

Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal

Analytical profiles of “legal highs” containing cathinones available in the area of Lisbon, Portugal

Mephedrone-Related Fatalities in the United Kingdom: Contextual, Clinical and Practical Issues

The Toxicology of Bath Salts: A Review of Synthetic Cathinones

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