Mephedrone-Related Fatalities in the United Kingdom: Contextual, Clinical and Practical Issues

Corkery, John; Schifano, Fabrizio; Ghodse, A. Hamid

doi:10.5772/32935

Cited by 6 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…year-old Caucasian man (Dickson, Vorce, Levine, & Past, 2010 (Blum et al, 2013;Elliott & Evans, 2014). This is in line with the National Programme on Substance Abuse Deaths findings (Corkery et al, 2012).…”

Section: Toxicity Of Cathinone Mixturessupporting

confidence: 86%

Intended and unintended use of cathinone mixtures

Guirguis

Corkery

Stair

et al. 2017

Human Psychopharmacology

Self Cite

View full text Add to dashboard Cite

Introduction Cathinones are one of the most popular categories of new psychoactive substances (NPS) consumed. Cathinones have different pharmacological activities and receptor selectivity for monoamine transporters based on their chemical structures. They are incorporated into NPS mixtures and used with other NPS or ‘traditional’ drugs. Cathinone use represents significant health risks to individuals and is a public health burden. Methods Evidence of poly‐NPS use with cathinones, seizure information, and literature analyses results on NPS mixtures was systematically gathered from online database sources, including Google Scholar, Scopus, Bluelight, and Drugs‐Forum. Results and discussion Results highlight the prevalence of NPS with low purity, incorporation of cathinones into NPS mixtures since 2008, and multiple members of the cathinone family being present in individual UK‐seized samples. Cathinones were identified as adulterants in NPS marketed as being pure NPS, drugs of abuse, branded products, herbal blends, and products labelled “not for human consumption.” Toxicity resulting from cathinone mixtures is unpredictable because key attributes remain largely unknown. Symptoms of intoxication include neuro‐psychological, psychiatric, and metabolic symptoms. Proposed treatment includes holistic approaches involving psychosocial, psychiatric and pharmacological interventions. Conclusion Raising awareness of NPS, education, and training of health care professionals are paramount in reducing harms related to cathinone use.

show abstract

Section: Toxicity Of Cathinone Mixturessupporting

confidence: 86%

Intended and unintended use of cathinone mixtures

Guirguis

Corkery

Stair

et al. 2017

Human Psychopharmacology

Self Cite

View full text Add to dashboard Cite

show abstract

“…The circumstances of α-PVP and pentedrone deaths resembled those relating to mephedrone described in the UK, e.g. falls from heights, drowning, hangings, as well as overdoses [87].…”

Section: Deathsmentioning

confidence: 97%

“…More than half of those in a student survey who had taken mephedrone reported adverse effects associated with the central nervous, nasal/respiratory, and cardiovascular systems [86]. Abdominal pain, flushing, sweating, chills, restlessness, and anxiety can be observed as well [9,70,71,87,88]. Additional reported serious effects include hyperthermia, rhabdomyolysis, renal failure, and seizures.…”

Section: Desired and Adverse Effectsmentioning

confidence: 99%

“…Mood disturbances and paranoid ideation have been observed in chronic users of cathinones, both natural and synthetic [87][88][89][90].…”

Section: Desired and Adverse Effectsmentioning

confidence: 99%

“…Deaths have been associated with a range of synthetic cathinones, including: mephedrone [87,88,90,101,102], methylone and butylone [103], ethylone [104], bupropion [82], α-PVP [95,105,106], MDPV [93,[107][108][109], and methedrone [110].…”

Section: Deathsmentioning

confidence: 99%

See 2 more Smart Citations

NPS: Medical Consequences Associated with Their Intake

Schifano

Orsolini

Papanti

et al. 2016

Current Topics in Behavioral Neurosciences

Self Cite

View full text Add to dashboard Cite

Over the last decade, the 'traditional' drug scene has been supplemented - but not replaced - by the emergence of a range of novel psychoactive substances (NPS), which are either newly created or existing drugs, including medications, now being used in novel ways. By the end of 2014, in excess of 500 NPS had been reported by a large number of countries in the world. Most recent data show, however, that synthetic cathinones, synthetic cannabinoids, and psychedelics/phenethylamines account for the largest number of NPS.The present chapter aims at providing an overview of the clinical and pharmacological issues relating to these most popular NPS categories. Given the vast range of medical and psychopathological issues associated with the molecules here described, it is crucial for health professionals to be aware of the effects and toxicity of NPS. A general overview of the acute management of NPS adverse events is provided as well, although further studies are required to identify a range of evidence-based, index molecule-focused, treatment strategies. The rapid pace of change in the NPS online market constitutes a major challenge to the provision of current and reliable scientific knowledge on these substances.

show abstract

Synthetic Cathinones—Prevalence and Motivations for Use

Corkery

Guirguis

Papanti

et al. 2018

Current Topics in Neurotoxicity

Self Cite

View full text Add to dashboard Cite

Please check the manuscript for details of any other licences that may have been applied and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (http://uhra.herts.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge. Take down policy If you believe that this document breaches copyright please contact us providing details, any such items will be temporarily removed from the repository pending investigation.

show abstract

Mephedrone-Related Fatalities in the United Kingdom: Contextual, Clinical and Practical Issues

Cited by 6 publications

References 40 publications

Intended and unintended use of cathinone mixtures

Intended and unintended use of cathinone mixtures

NPS: Medical Consequences Associated with Their Intake

Synthetic Cathinones—Prevalence and Motivations for Use

Contact Info

Product

Resources

About