Fluorochrome Stains for Histological Diagnosis of Visceral Mycoses

Bader, G.; Stiller, D; Ruffert, K

doi:10.1038/208796a0

Cited by 7 publications

(2 citation statements)

References 2 publications

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“…It can bind to DNA [13, 14], RNA [15, 16], lysosome [17, 18], and glycosaminoglycans [19]in living cells as well as in parasites (malaria) [22, 23], fungi [24], bacteria [25], and viruses [26, 27]. It has the capability to emit fluorescence by excitation with light [28, 29, 30].…”

Section: Discussionmentioning

confidence: 99%

Acridine Orange Excited by Low-Dose Radiation Has a Strong Cytocidal Effect on Mouse Osteosarcoma

Hashiguchi¹,

Kusuzaki²,

Murata³

et al. 2002

Oncology

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The study was conducted to clarify the cytocidal effect of combination therapy consisting of administration of acridine orange (AO), which is a photosensitizer, and radiation therapy using in vitro and in vivo mouse osteosarcoma models. The results revealed that AO combined with low-dose X-ray irradiation of about 1–5 Gy had a strong cytocidal effect on the cultured mouse osteosarcoma cells regardless of their chemosensitivity, and that this combination therapy inhibited growth of the in vivo mouse osteosarcoma by induction of tumor necrosis. This effect was inhibited by L-histidine, but not by mannitol. These findings suggested that AO might be excited by X-rays and kill osteosarcoma cells through the release of singlet oxygen, which is toxic to living cells. This mechanism is similar to that of photodynamic therapy with AO.

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Section: Discussionmentioning

confidence: 99%

Acridine Orange Excited by Low-Dose Radiation Has a Strong Cytocidal Effect on Mouse Osteosarcoma

Hashiguchi¹,

Kusuzaki²,

Murata³

et al. 2002

Oncology

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“…AO emits green (533 nm) or orange (656 nm) fluorescence following blue light (492 nm) excitation. Since AO has a very low molecular weight (MW 265), it has the capability to rapidly flow into the cytoplasm through the plasma membrane binding to the DNA, RNA 97 , 98 ) and acidic lysosomes 99 , 100 . AO selectively accumulates in cancer cells, especially in acidic lysosomes, emits fluorescence after blue excitation, and kills cancer cells via apoptosis by activated oxygen.…”

Section: Photodynamic Molecules and Cancermentioning

confidence: 99%

Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

Kusuzaki

Matsubara

Murata

et al. 2017

Journal of Enzyme Inhibition and Medicinal Chemistry

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Photodynamic molecules represent an alternative approach for cancer therapy for their property (i) to be photo-reactive; (ii) to be not-toxic for target cells in absence of light; (iii) to accumulate specifically into tumour tissues; (iv) to be activable by a light beam only at the tumour site and (v) to exert cytotoxic activity against tumour cells. However, to date their clinical use is limited by the side effects elicited by systemic administration. Extracellular vesicles are endogenous nanosized-carriers that have been recently introduced as a natural delivery system for therapeutic molecules. We have recently shown the ability of human exosomes to deliver photodynamic molecules. Therefore, this review focussed on extracellular vesicles as a novel strategy for the delivery of photodynamic molecules at cancer sites. This completely new approach may enhance the delivery and decrease the toxicity of photodynamic molecules, therefore, represent the future for photodynamic therapy for cancer treatment.

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Mucormycosis

Baker

1971

The Pathologic Anatomy of Mycoses

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Fluorochrome Stains for Histological Diagnosis of Visceral Mycoses

Cited by 7 publications

References 2 publications

Acridine Orange Excited by Low-Dose Radiation Has a Strong Cytocidal Effect on Mouse Osteosarcoma

Acridine Orange Excited by Low-Dose Radiation Has a Strong Cytocidal Effect on Mouse Osteosarcoma

Natural extracellular nanovesicles and photodynamic molecules: is there a future for drug delivery?

Mucormycosis

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