Fluoro aromatic imine nickel(0) complexes: Synthesis and structural studies

Iglesias, Ana Leticia; Muñoz‐Hernández, Miguel‐Ángel; Garcı́a, Juventino J.

doi:10.1016/j.jorganchem.2007.04.026

Cited by 22 publications

(13 citation statements)

References 34 publications

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“…A set of closely related Ni(dippe)(η 2 -imine) complexes, recently reported by J. J. García and co-workers, containing fluorinated imine ligands show nearly identical coordination shifts of ca. 100 ppm . Therefore, 13 C coordination shifts indicate that π-acceptor capabilities decrease in the order CO > CN ≥ CC.…”

Section: Resultsmentioning

confidence: 99%

Decomposition of Methylnickel(II) Amido, Alkoxo, and Alkyl Complexes by β-Hydrogen Elimination: A Comparative Study

et al. 2009

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Thermal decomposition of structurally related amido, alkoxo, and alkyl complexes of type [Ni(Me)(EC(H)RR′)(dippe)] (EC(H)RR′ = cyclo-NC4H8 (pyrrolidino), N(CH2Ph)2, OCH2Ph, OCH(Me)Ph, and CH2CH2Ph) takes place through formally analogous processes involving β-hydrogen elimination and reductive elimination of methane, cleanly affording corresponding Ni(0) imine, aldehyde, ketone, and olefin complexes, [Ni(η2-ECRR′)(dippe)]. Kinetic studies on these decomposition reactions show that, in spite of their similarity, they involve substantial mechanistic differences.

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Section: Resultsmentioning

confidence: 99%

Decomposition of Methylnickel(II) Amido, Alkoxo, and Alkyl Complexes by β-Hydrogen Elimination: A Comparative Study

et al. 2009

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“…Inspired by the aforementioned and continuing our work on Schiff base compounds and their applications [23][24][25][26] , the pyrazole nucleus was incorporated into the design and architecture of the imine ligand, with the goal of finding compounds that elicit and enhance bioactivity. The synthesis of two homologous families of NNN-bis(imino)pyridine and NN-bis(imino) benzene compounds derived from 3-aminopyrazole was reported, as well as their biological activity was evaluated.…”

Section: 6-bis(26-dimethyl-phenyl-iminomethyl)pyridine (2)mentioning

confidence: 99%

Biological Activity of New Schiff Base Compounds Derived from Substituted 3-Aminopyrazoles, the Role of Pyrazole on Bioactivity

Iglesias¹,

Miranda-Soto²,

Pompa-Monroy³

et al. 2019

pharmaceutical-sciences

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Treatment of infectious diseases is an ever-increasing problem owing to the growing number of multi-drug resistant pathogens. Nosocomial infections are on the rise due to antibiotic-resistant microorganisms, which have led to increased morbidity and mortality in many hospitals. Cancer is a major disease worldwide [1] ; colorectal cancer particularly, is the second leading cause of death by cancer in Western countries and has one of the highest mortality rates in both men and women. These cancer patients are especially susceptible to nosocomial infections; as a result of their immunosuppressed systems (due to the treatments associated with illness); which in turn leads to prolonged stays, disability and economic burden [2,3]. Therefore, the search for novel compounds that displayed a broad range of therapeutic activities that can address these major health problems is of outmost importance [4]. New therapeutic drugs that contain a heterocyclic core are on the forefront of pharmaceutical research [5,6]. Pyrazoles, (1,2-azoles) have proven to be a remarkable scaffold for the synthesis of biologically active compounds [7-9] thanks to their wide range of medical applications that center mainly on antimicrobial [10-12] , antifungal [8,12,13] , antiinflammatory [7] , analgesic, and anxiolytic activities [13,14]. Some pyrazole derivatives have also shown antitumor activities towards several cancer cell lines, including leukemia (K562), HeLa cervix adenocarcinoma and Fem-x melanoma [14]. Consequently, in recent years pyrazole-base compounds have become a target of great interest.

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“…Since amines are important building blocks in the pharmaceuticals and fine chemicals industry [42] the demonstration of novel, efficient, atom-efficient synthetic routes continues to be of widespread interest. [44] The use of such compounds in catalysis, under low hydrogen pressure and in the presence of excess fluorinated imines resulted in high conversions of the latter into their corresponding amines. Incidentally, the preparation of pure fluoro-substituted arylamines finds added value in pharmacology, due to their potential use in novel therapies.…”

Section: ) Hydrogenation and Activation Of Related Multiple Bondsmentioning

confidence: 99%

“…We initially explored the coordination of fluoro imines to nickel, to yield the expected nickel(0) complexes of the type, [(dippe)Ni{η 2 ‐( N , C )‐PhHC=NAr F n }], wherein Ar F n refers to the increasing degree of fluorination exhibited by the N ‐aryl moiety ( n = 0, 1, 2, 3, 4, 5), see below 44 …”

Section: ) Hydrogenation and Activation Of Related Multiple Bondsmentioning

confidence: 99%