Fluoro-apatite and Calcium Phosphate Nanoparticles by Flame Synthesis

Loher, Stefan; Stark, Wendelin J.; Maciejewski, Marek; Baiker, Alfons; Pratsinis, Sotiris E.; Reichardt, Dennis; Maspero, Fabrice; Krumeich, Frank; Günther, Detlef

doi:10.1021/cm048776c

Cited by 182 publications

(178 citation statements)

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“…Spherical and highly agglomerated amorphous TCP nanoparticles in the size range of 20-50 nm were successfully produced by flame spray synthesis as shown in earlier studies [31]. …”

Section: Tcp Nanoparticlesmentioning

confidence: 85%

“…Eur.) dissolved in 2-ethylhexanoic acid (Fluka, puriss) and tributyl phosphate (Fluka, puriss) as precursors [31][32][33]. The liquid mixture with a molar ratio of Ca/P = 1.5 was diluted with toluene (Fluka, puriss) (2:1 vol/vol) and fed through a capillary (diameter 0.4 mm) into a methane/oxygen flame at a rate of 5 ml min …”

Section: Preparation Of Tcp Particlesmentioning

confidence: 99%

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In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects

et al. 2009

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In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects AbstractThe easy clinical handling and applicability of biomaterials has become a focus of materials research due to rapidly increasing time and cost pressures in the public health sector. The present study assesses the in vitro and in vivo performance of a flexible, mouldable, cottonwool-like nanocomposite based on poly(lactide-co-glycolide) and amorphous tricalcium phosphate nanoparticles (PLGA/TCP 60:40). Immersion in simulated body fluid showed exceptional in vitro bioactivity for TCP-containing fibres (mass gain: 18%, 2 days, HAp deposition). Bone regeneration was quantitatively investigated by creating four circular non-critical-size calvarial defects in New Zealand White rabbits. The defects were filled with the easy applicable cottonwool-like PLGA/TCP fibres or PLGA alone. Porous bovine-derived mineral (Bio-Oss) was used as a positive control and cavities left empty served as a negative control. The area fraction of newly formed bone (4 weeks implantation) was significantly increased for TCP-containing fibres compared to pure PLGA (histological and micro-computed tomographic analysis). A spongiosa-like structure of the newly formed bone tissue was observed for PLGA/TCP nanocomposites, whereas Bio-Oss-treated defects afforded a solid cortical bone.-1-

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“…Spherical and highly agglomerated amorphous TCP nanoparticles in the size range of 20-50 nm were successfully produced by flame spray synthesis as shown in earlier studies [31]. …”

Section: Tcp Nanoparticlesmentioning

confidence: 85%

Section: Preparation Of Tcp Particlesmentioning

confidence: 99%

In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects

et al. 2009

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“…Amorphous tricalcium phosphate nanoparticles were prepared by flame spray synthesis [31] as described by Loher et al [32]. Briefly, calcium hydroxide (Riedel de Haen, Ph.…”

Section: Preparation Of Amorphous Tricalcium Phosphate Nanoparticlesmentioning

confidence: 99%

Spherical calcium phosphate nanoparticle fillers allow polymer processing of bone fixation devices with high bioactivity

Mohn

Ege

Feldman

et al. 2009

Polymer Engineering & Sci

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Treatment of bone defects generally requires a fixation device. Biodegradable implants can often prevent second operations in contrast to metallic implants that are surgically removed after healing. In this study, we investigate the preparation of a bone fixation device with additional bioactivity by adding nanoparticulate amorphous tricalcium phosphate (ATCP) to improve bonding to bone. Medically approved poly(lactide-co-glycolide) (PLGA) and spherical (ATCP) nanoparticles were blended directly or through a two-step approach, where ATCP was first dispersed in PLGA by solvent casting, extruded and hot pressed producing blocks and bone screws. The latter route yielded good particle dispersion while blending alone led to inhomogeneous mixtures. Samples were immersed in simulated body fluid and showed rapid formation of surface hydroxyapatite layers (examined by X-ray diffraction and scanning electron microscopy) already after 3 days, thus confirming very high bioactivity. Polymer degradation during processing and upon simulated implantation conditions was followed by gel permeation chromatography. The elevated temperature during extrusion was the strongest single factor contributing to PLGA degradation. Screws could be machined out of extruded cylinders and demonstrated the ability to process PLGA/ATCP 90/10 composites with regular workshop tools. These properties suggest the use of such composites as improved, bioactive, and degradable bone fixation systems particularly in oral and maxillofacial surgery. POLYM. ENG. SCI., 50:952-960, 2010. (C) ABSTRACTTreatment of bone defects generally requires a fixation device. Biodegradable implants can often prevent second operations in contrast to metallic implants that are surgically removed after healing. In this study, we investigate the preparation of a bone fixation device with additional bioactivity by adding nanoparticulate amorphous tricalcium phosphate (ATCP) to improve bonding to bone. Medically approved poly(lactide-co-glycolide) (PLGA) and spherical (ATCP) nanoparticles were blended directly or through a two-step approach, where ATCP was first dispersed in PLGA by solvent casting, extruded and hot pressed producing blocks and bone screws. The latter route yielded good particle dispersion while blending alone led to inhomogeneous mixtures. Samples were immersed in simulated body fluid (SBF) and showed rapid formation of surface hydroxyapatite layers (examined by X-ray diffraction and scanning electron microscopy) already after 3 days, thus confirming very high bioactivity. Polymer degradation during processing and upon simulated implantation conditions was followed by gel permeation chromatography. The elevated temperature during extrusion was the strongest single factor contributing to PLGA degradation. Screws could be machined out of extruded cylinders and demonstrated the ability to process PLGA/ATCP 90/10 composites with regular workshop tools. These properties suggest the use of such composites as improved, bioactive, and degradable bone fixation ...

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“…The binding of Zn 2+ is proposed to lead to the precipitation of an apatite-like phase, and the formation of a zinc complex at the surface of enamel has been suggested. 47,[51][52][53][54] The work presented here employs a new approach for the study of dissolution processes, coupling localized measurements with high and controlled mass transport through the use of SECCM. [55][56][57][58][59] The aim is to demonstrate the methodology and to gain a better understanding of the acid induced dissolution process on enamel surfaces as well as the effect of treating the enamel surface with zinc and fluoride.…”

Section: Introductionmentioning

confidence: 99%

Combinatorial localized dissolution analysis: Application to acid-induced dissolution of dental enamel and the effect of surface treatments

Parker

Botros

Kinnear

et al. 2016

Journal of Colloid and Interface Science

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(2016) Combinatorial localized dissolution analysis : application to acid-induced dissolution of dental enamel and the effect of surface treatments. Journal of Colloid and Interface Science, 476. pp. 94-102. Permanent WRAP URL:http://wrap.warwick.ac.uk/81648 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. A note on versions:The version presented here may differ from the published version or, version of record, if you wish to cite this item you are advised to consult the publisher's version. Please see the 'permanent WRAP URL' above for details on accessing the published version and note that access may require a subscription. A combination of scanning electrochemical cell microscopy (SECCM) and atomic force microscopy (AFM) is used to quantitatively study the acid-induced dissolution of dental enamel. A micron-scale liquid meniscus formed at the end of a dual barrelled pipette, which constitutes the SECCM probe, is brought into contact with the enamel surface for a defined period. Dissolution occurs at the interface of the meniscus and the enamel surface, under conditions of well-defined mass transport, creating etch pits that are then analysed via AFM. This technique is applied to bovine dental enamel, and the effect of various treatments of the enamel surface on acid dissolution (1mM HNO 3) is studied. The treatments investigated are zinc ions, fluoride ions and the two combined. A finite element method (FEM) simulation of SECCM mass transport and interfacial reactivity, allows the intrinsic rate constant for acid-induced dissolution to be quantitatively determined. The dissolution of enamel, in terms of Ca 2+ flux ( 2+ ), is first order with respect to the interfacial proton concentration and given by the following rate law:, with 0 = 0.099 ±0.008 cm.s -1 . Treating the enamel with either fluoride or zinc slows the dissolution rate, although in this model system the partly protective barrier only extends around 10-20 nm into the enamel surface, so that after a period of a few seconds dissolution of modified surfaces tends towards that of native enamel. A combination of both treatments exhibits the greatest protection to the enamel surface, but the effect is again transient.

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Fluoro-apatite and Calcium Phosphate Nanoparticles by Flame Synthesis

Cited by 182 publications

References 48 publications

In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects

In vivo and in vitro evaluation of flexible, cottonwool-like nanocomposites as bone substitute material for complex defects

Spherical calcium phosphate nanoparticle fillers allow polymer processing of bone fixation devices with high bioactivity

Combinatorial localized dissolution analysis: Application to acid-induced dissolution of dental enamel and the effect of surface treatments

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