Fluorinated star-shaped block copolymers: Synthesis and optical properties

Qu, Jing; Luo, Xinran; Wang, Zhonggang

doi:10.1002/pola.28056

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…Inc. Other reagents such as diethyl ether, tetrahydrofuran (THF), cuprous bromide (CuBr), and 2-DEAEMA were treated through the common purification methods just before use. Tetrakis(4-(1-bromoethyl)phenyl)silane (BTES) was synthesized in accordance with the method reported in our paper …”

Section: Methodsmentioning

confidence: 99%

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Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

2019

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This paper presents the design and synthesis of star-shaped copolymers with two poly [2-(diethylamino)ethyl methacrylate] and poly(ethylene glycol) blocks linked via a disulfide bond and each end of the four arms capped by folic acid (FA), from which the prepared nanodrug carriers simultaneously possess pH/redox dual response and active targeting functions. The polymer micelles exhibit excellent stability as reflected by their low critical micelle concentration values of 1.03−2.51 mg/L. The doxorubicin (DOX)-loaded polymer micelles are in the range of 108 to 143 nm, and the DOX-loading capacities are found to be up to 32.3%. The sensitive pH and redox responses are demonstrated by examining the drug release behaviors under the varied acidic condition from pH 7.4 to 5.0 and the glutathione concentrations from 0 to 10 mM, respectively. Moreover, the observation of confocal laser scanning microscopy confirms that the functionalization of arm ends by FA indeed enhances the internalization of DOXloaded micelle particles in HeLa cells. As a result, the DOX-loaded nanocarriers can deliver therapeutic drugs to target HeLa cells, and the viability of HeLa cells (10.1%) approaches the value of the pristine DOX (9.98%), showing promising application as drug delivery nanocarriers for safe and highly efficient cancer therapy.

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Section: Methodsmentioning

confidence: 99%

“…Tetrakis(4-(1-bromoethyl)phenyl)silane (BTES) was synthesized in accordance with the method reported in our paper. 52 Synthesis of HO-PEG-CDI. The CDI solution with 1.22 g of CDI in 20 mL of anhydrous dichloromethane (DCM) was added dropwise in 30 mL 50% DCM solution of PEG.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

2019

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“…DEAEMA and HEMA were distilled to remove the inhibitor just prior to use. CuBr was purified by stirring over acetic acid for 24 h at room temperature followed by washing with acetone before drying at 40 °C under vacuum for 24 h. Tetrakis(4‐(1‐bromoethyl)phenyl)silane (BTES) was prepared according to the procedure described in the previous paper …”

Section: Methodsmentioning

confidence: 99%

Tetraphenylsilane‐Cored Star‐Shaped Amphiphilic Block Copolymers for pH‐Responsive Anticancer Drug Delivery

Shang

Guo

Wang

2019

Macro Chemistry & Physics

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/macp.201900248. Amphiphilic CopolymersFour-arm star-shaped poly[2-(diethylamino)ethyl methacrylate]-b-poly[2hydroxyethyl methacrylate]s block copolymers using tetraphenylsilane (TPS) as a core with adjustable arm lengths are synthesized through two-step atom transfer radical polymerizations. For comparison, a linear block copolymer with similar molecular weight is also prepared. The assembled star-shaped copolymer micelles exhibit sizes of 102-139 nm and critical micelle concentrations of 1.49-3.93 mg L −1 . Moreover, the bulky and rigid TPS core is advantageous for propping up the four star-shaped arms to generate large intersegmental space. As a result, the drug-loading capacity in the micelles is up to 33.97 wt%, much surpassing the linear counterpart (8.92 wt%) and the previously reported star-shaped copolymers prepared using pentaerythritol as the core. Furthermore, the micelles show sensitive pH-responsive drug release when the pH changes from 7.4 to 5.0. The in vitro cytotoxicity to Hela cells indicates that the doxorubicin (DOX)-loaded micelles have similar anticancer activity to the pristine DOX. The combination of excellent micelle stability, high drug-loading, sensitive pH response, and good anticancer activity endows the copolymers with promising application in drug control delivery for anticancer therapy.

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“…Fluorine-containing polymers are attractive materials that can satisfy the wettability and transparency requirements of surfaces because of their low surface energy and low reflective index. ,− Moreover, they exhibit outstanding properties such as unique water and oil repellency, self-cleaning capability, excellent thermal and chemical stability, and low dielectric constant. − On the other hand, the practical applications of fluorine-containing polymers are limited by their low solubility in common solvents, low compatibility with hydrocarbon polymers, low adhesion to any substrate, and high cost. Copolymerization with various monomers has been explored as an alternative to overcome these limitations. ,,− …”

Section: Introductionmentioning

confidence: 99%

Controllable Surface and Optical Properties of Methacrylic Copolymer Films Using Various Monomer Combinations

et al. 2018

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Various fluorinated methacrylic copolymers (PFPMA- X) were prepared from 2,2,3,3,3-pentafluoropropyl methacrylate (PFPMA), methyl methacrylate (MMA), and three other nonfluorinated monomers. The surface and the optical properties of these copolymers were controlled by changing the ratio of PFPMA to MMA while keeping the sum of the concentration of the two monomers fixed at 60 wt %. The parameter X represents the nominal concentration of PFPMA in various feed ratios of all five monomers. Depending on the increase in PFPMA content in PFPMA- X, the surface energy varied proportionately between 26.7 (PFPMA content: 20 wt %) and 17.4 mN/m (PFPMA content: 60 wt %), which is well-correlated with the fluorine content on the surface. Interestingly, we found that all PFPMA- X-coated glasses showed different transmittance curves in the wavelength range of 300-700 nm, and the wavelength at which maximum transmittance was recorded shifted as a function of the copolymer composition. In addition, the surface coatings of PFPMA- X with higher fluorine contents increased the transmittance of bare glass by approximately 1-2%. Quite lower and tunable refractive indices were obtained depending on the fluorine content, and all PFPMA- X showed extremely lower birefringences. Freestanding films of PFPMA- X were also well-formed, indicating that they can be used in a wide range of applications.

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Fluorinated star-shaped block copolymers: Synthesis and optical properties

Cited by 6 publications

References 38 publications

Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

Tetraphenylsilane‐Cored Star‐Shaped Amphiphilic Block Copolymers for pH‐Responsive Anticancer Drug Delivery

Controllable Surface and Optical Properties of Methacrylic Copolymer Films Using Various Monomer Combinations

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