Tetraphenylsilane‐Cored Star‐Shaped Amphiphilic Block Copolymers for pH‐Responsive Anticancer Drug Delivery

Shang, Yingqi; Guo, Lingxiao; Wang, Zhonggang

doi:10.1002/macp.201900248

Cited by 8 publications

(6 citation statements)

References 38 publications

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“…The cmc values of FA-PEG-SS-PDEAEMA were determined by the fluorescence probe technique using pyrene as a fluorescent probe. The entrapment efficiency (EE), loading content (LC) of DOX in the DOX-loaded polymer micelles, in vitro DOX release, and cell cytotoxicity assay were carried out in accordance with the methods described in the previous paper …”

Section: Methodsmentioning

confidence: 99%

“…1 Synthesis of Macroinitiators (BDs). Three star-shaped BDs with different arm lengths were synthesized in accordance with the procedure in the paper 53 except that the ratios of the reactants charged in the system are different. Specifically, the fed molar ratios of BETS/CuBr/CuBr 2 /PMDETA/DEAEMA for BD-1, BD-2, and BD-3 are 1/4.5/1.35/5/140, 1/4.5/1.35/5/120, and 1/4.5/1.35/5/100, respectively.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

2019

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This paper presents the design and synthesis of star-shaped copolymers with two poly [2-(diethylamino)ethyl methacrylate] and poly(ethylene glycol) blocks linked via a disulfide bond and each end of the four arms capped by folic acid (FA), from which the prepared nanodrug carriers simultaneously possess pH/redox dual response and active targeting functions. The polymer micelles exhibit excellent stability as reflected by their low critical micelle concentration values of 1.03−2.51 mg/L. The doxorubicin (DOX)-loaded polymer micelles are in the range of 108 to 143 nm, and the DOX-loading capacities are found to be up to 32.3%. The sensitive pH and redox responses are demonstrated by examining the drug release behaviors under the varied acidic condition from pH 7.4 to 5.0 and the glutathione concentrations from 0 to 10 mM, respectively. Moreover, the observation of confocal laser scanning microscopy confirms that the functionalization of arm ends by FA indeed enhances the internalization of DOXloaded micelle particles in HeLa cells. As a result, the DOX-loaded nanocarriers can deliver therapeutic drugs to target HeLa cells, and the viability of HeLa cells (10.1%) approaches the value of the pristine DOX (9.98%), showing promising application as drug delivery nanocarriers for safe and highly efficient cancer therapy.

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Section: Methodsmentioning

confidence: 99%

Section: ■ Experimental Sectionmentioning

confidence: 99%

Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

2019

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“…Alkynyl-functionalized methoxypolyethylene glycols (alkynyl-mPEG, M n = 2000) was purchased from Aichun Biological Technology CO., Ltd. (Shanghai, China). 1,3,5,7-Tetrahydroxyadamantane (Ad-(OH) 4 ) was synthesized according to the reported literature [ 29 ]. Dulbecco’s Modified Eagle’s Medium (DMEM) and fetal bovine serum (FBS) were bought from the Biological Industries (BI, Beit-Haemek, Israel).…”

Section: Methodsmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

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Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N’-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well controlled drug release behavior (18.5–19.0% of DOX release at pH 7.4 and 77.6–78.8% of DOX release at pH 5.0 within 80 h), good cytocompatibility against NIH-3T3 cells and effective anticancer efficacy against MCF-7 cells. However, the star-shaped polymeric micelles exhibited preferable stability, which was confirmed by the lower critical micelle concentration (CMC 0.0034 mg/mL) and decrease rate of particle sizes after 7 days incubation (3.5%), compared with the linear polymeric micelle L-PLGA-D-P (CMC 0.0070 mg/mL, decrease rate of particle sizes was 9.6%). Overall, these developed polymeric micelles have promising application as drug delivery system in cancer therapy.

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“…Until now, tertaphenylsilane derivatives have been mainly studied for their use in light-emitting diodes, but the above-mentioned optoelectronic and physicochemical properties make them an excellent candidate for use in medicine and biosensors. Y. Shang et al reported that the star-shaped amphiphilic poly[2-(diethylamino)ethylmethacrylate]-b-poly[2-hydroxyethyl methacrylate]s copolymers, using tetraphenylsilane as a core, exhibit merits in comparison with the linear counterpart, including enhanced micelle stability, high drug-loading, and entrapment efficiency [ 105 ]. The π–π interaction between tetraphenylsilane cores results in excellent stability of micelles assembled from the star-shaped copolymers with critical micelle concentration (CMC) values in the range from 1.49 to 3.93 mg L −1 .…”

Section: Application In Different Fieldsmentioning

confidence: 99%

Conducting Silicone-Based Polymers and Their Application

et al. 2021

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Over the past two decades, both fundamental and applied research in conducting polymers have grown rapidly. Conducting polymers (CPs) are unique due to their ease of synthesis, environmental stability, and simple doping/dedoping chemistry. Electrically conductive silicone polymers are the current state-of-the-art for, e.g., optoelectronic materials. The combination of inorganic elements and organic polymers leads to a highly electrically conductive composite with improved thermal stability. Silicone-based materials have a set of extremely interesting properties, i.e., very low surface energy, excellent gas and moisture permeability, good heat stability, low-temperature flexibility, and biocompatibility. The most effective parameters constructing the physical properties of CPs are conjugation length, degree of crystallinity, and intra- and inter-chain interactions. Conducting polymers, owing to their ease of synthesis, remarkable environmental stability, and high conductivity in the doped form, have remained thoroughly studied due to their varied applications in fields like biological activity, drug release systems, rechargeable batteries, and sensors. For this reason, this review provides an overview of organosilicon polymers that have been reported over the past two decades.

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Tetraphenylsilane‐Cored Star‐Shaped Amphiphilic Block Copolymers for pH‐Responsive Anticancer Drug Delivery

Cited by 8 publications

References 38 publications

Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

Tetraphenylsilane-Cored Star-Shaped Polymer Micelles with pH/Redox Dual Response and Active Targeting Function for Drug-Controlled Release

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Conducting Silicone-Based Polymers and Their Application

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