Abstract:Pluronics (PEO-PPO-PEO or PPO-PEO-PPO),
as the first commercially
used polymeric surfactants, designed and manufactured by BASF, have
been applied in the development of many pharmaceutical formulations
and drug load as well as delivery. Herein, the Williamson ether synthesis
reaction was used to prepare hydrophobic monomer fluorinated epichlorohydrin
(EPTF) considered as an intermediate state before. In addition, ABA
triblock amphiphilic polymers (molecular weight ranging from 2083
to 8888 g/mol with the polym… Show more
Polymeric surfactants are a special class of the polymers that have amphiphilic characteristics of surfactants. In selective solvents, polymeric surfactants exhibit interesting association processes and develop self‐assembled structures. Their capacity to create micellar aggregates with stimuli‐responsive behavior in aqueous solutions, enables the creation of smart materials for many applications. The only restrictions to the creation of polymeric surfactants with complicated structures using current synthetic methods are the researchers' interests and creativity. The chemical structure of the polymer and its aqueous solution characteristics (viscosity and surface tension) should be demonstrated as having a distinct and commonly accepted connection. Unavailability of systematic and updated review on these important molecules demands a comprehensive compilation and consistent discussion on key physical aspects, characterization, synthetic techniques, and their useful applications like enhanced recovery of oil, antimicrobial potential, water treatment, pharmaceutical, etc.
Polymeric surfactants are a special class of the polymers that have amphiphilic characteristics of surfactants. In selective solvents, polymeric surfactants exhibit interesting association processes and develop self‐assembled structures. Their capacity to create micellar aggregates with stimuli‐responsive behavior in aqueous solutions, enables the creation of smart materials for many applications. The only restrictions to the creation of polymeric surfactants with complicated structures using current synthetic methods are the researchers' interests and creativity. The chemical structure of the polymer and its aqueous solution characteristics (viscosity and surface tension) should be demonstrated as having a distinct and commonly accepted connection. Unavailability of systematic and updated review on these important molecules demands a comprehensive compilation and consistent discussion on key physical aspects, characterization, synthetic techniques, and their useful applications like enhanced recovery of oil, antimicrobial potential, water treatment, pharmaceutical, etc.
“…Travoprost is loaded in the micelles via a solvent evaporation method. We hypothesize that pentafluoroethyl groups could not incorporate into the PFPE core because fluorophilic effect of two fluorocarbons is too weak to self-assembly [28] and the steric effect of PEG prevents pentafluoroethyl groups from interacting with the core while it still could repel positively charged CPPs on the surface. Here, RGD improves micelle-membrane interactions.…”
“…[23][24][25] Pluronics are generally known as poloxamers (structure of PEOx-PPOy-PEOx) consisted of hydrophilic head and hydrophobic core of poly ethylene oxide (PEO) and poly (propylene oxide) (PPO), respectively. [26][27][28][29][30][31] Pluronics are naturally amphiphilic, capable of self-assembling into nano micelles, and capable of encapsulating and delivering hydrophobic nutraceuticals to target areas in a pH-responsive way. [32][33][34] For the drug delivery applications, targeted drug delivery via modification or functionalization of polymers is more considerable compared to nonspecific drug delivery polymers because it enables the target specific delivery of hydrophobic drugs.…”
Section: Introductionmentioning
confidence: 99%
“…[ 23–25 ] Pluronics are generally known as poloxamers (structure of PEOx‐PPOy‐PEOx) consisted of hydrophilic head and hydrophobic core of poly ethylene oxide (PEO) and poly (propylene oxide) (PPO), respectively. [ 26–31 ] Pluronics are naturally amphiphilic, capable of self‐assembling into nano micelles, and capable of encapsulating and delivering hydrophobic nutraceuticals to target areas in a pH‐responsive way. [ 32–34 ]…”
Evodiamine (Evo) is a natural, biologically active plant alkaloid with wide range of pharmacological activities. In the present study Evo‐loaded folate‐conjugated Pluronic F108 nano‐micelles (ENM) is synthesized to enhance the therapeutic efficacy of Evo against cervical cancer. ENM are synthesized, physicochemically characterized and in vitro anticancer activity is performed. The study demonstrates that ENM have nanoscale size (50.33 ± 3.09 nm), monodispersity of 0.122 ± 0.072, with high drug encapsulation efficiency (71.30 ± 3.76%) and controlled drug release at the tumor microenvironment. ENM showed dose‐dependent and time‐dependent cytotoxicity against HeLa human cervical cancer cells. The results of in vitro anticancer studies demonstrated that ENM have significant anticancer effects and greatly induce apoptosis as compared to pure Evo. The cellular uptake study suggests that increased anticancer activity of ENM is due to the improved intracellular delivery of Evo through overexpressed folate receptors. Overall, the designed ENM can be a potential targeted delivery system for hydrophobic anticancer bioactive compound like Evo.
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