Fluorinated carboxymethyl chitosan-based nano-prodrugs for precisely synergistic chemotherapy

Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy

“…Polysaccharide based nano prodrugs have attracted widespread attention due to their clear component, accurate structure, stable drug loading capacity, and efficient anti-tumor activity. 14,15 Chitosan (CS) is a natural non-toxic polymer material with good biodegradability and biocompatibility, which has been widely used in the delivery of anti-tumor drugs for cancer diagnosis and therapy. 16,17 In addition, CS has a large number of amino groups (-NH 2 ) and hydroxyl groups (-OH), which are excellent modication sites for functionalization.…”