Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy

Ma, Weiwei; Zhao, Qiufeng; Zhu, Shilong; Wang, Xinyue; Zhang, Chuangchuang; Ma, Daming; Li, Na; Yin, Yanyan

doi:10.1039/d4ra00610k

Cited by 2 publications

(1 citation statement)

References 36 publications

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“… 71 The carried drugs can be encapsulated within the particles, adsorbed onto the surface, or covalently linked to the particle surface. 67 Moreover, the surface of polymer nanoparticles can be designed by using different polymer end groups or by coupling specific polymers to achieve targeting and prolonged circulation time. In the construction of polymer nanoparticles, disulfide bonds are often used as connections between different polymer molecules, or between polymer molecules and drugs.…”

Section: Type Of Drug Delivery Carrier Based On Disulfide Bondmentioning

confidence: 99%

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Ma,

Wang,

Zhang

et al. 2024

IJN

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Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, a narrow therapeutic window, and unfavorable pharmacokinetic properties. To solve the above problems, target drug delivery to tumor cells, and reduce the side effects of drugs, an anti-tumor drug delivery system based on tumor microenvironment has become a focus of research in recent years. The construction of a reduction-sensitive nanomedicine delivery system based on disulfide bonds has attracted much attention. Disulfide bonds have good reductive responsiveness and can effectively target the high glutathione (GSH) levels in the tumor environment, enabling precise drug delivery. To further enhance targeting and accelerate drug release, disulfide bonds are often combined with pH-responsive nanocarriers and highly expressed ligands in tumor cells to construct drug delivery systems. Disulfide bonds can connect drug molecules and polymer molecules in the drug delivery system, as well as between different drug molecules and carrier molecules. This article summarized the drug delivery systems (DDS) that researchers have constructed in recent years based on disulfide bond drug delivery systems targeting the tumor microenvironment, disulfide bond cleavage-triggering conditions, various drug loading strategies, and carrier design. In this review, we also discuss the controlled release mechanisms and effects of these DDS and further discuss the clinical applicability of delivery systems based on disulfide bonds and the challenges faced in clinical translation.

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Section: Type Of Drug Delivery Carrier Based On Disulfide Bondmentioning

confidence: 99%

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Ma,

Wang,

Zhang

et al. 2024

IJN

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Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer

Xu,

Zhou,

Yang

et al. 2024

J Nanobiotechnol

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Pazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic activities against various human cancers. However, its clinical utility is limited by substantial side effects and therapeutic resistance. We developed a nanoplatform capable of delivering PAZ for enhanced anti-breast cancer therapy. Nanometer-sized PAZ@Fe-MOF, compared to free PAZ, demonstrated increased anti-tumor therapeutic activities in both syngeneic murine 4T1 and xenograft human MDA-MB-231 breast cancer models. High-throughput single-cell RNA sequencing (scRNAseq) revealed that PAZ@Fe-MOF significantly reduced pro-tumorigenic M2-like macrophage populations at tumor sites and suppressed M2-type signaling pathways, such as ATF6-TGFBR1-SMAD3, as well as chemokines including CCL17, CCL22, and CCL24. PAZ@Fe-MOF reprogramed the inhibitory immune microenvironment and curbed tumorigenicity by blocking the polarization of M2 phenotype macrophages. This platform offers a promising and new strategy for improving the cytotoxicity of PAZ against breast cancers. It provides a method to evaluate the immunological response of tumor cells to PAZ-mediated treatment.

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Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy

Abstract: HA-coated redox sensitive visualized nano-prodrug HA/TPE-CS-SS-PTX were exploited in order to highly efficient treatment of cancer and real-time monitoring of drug localization.

Cited by 2 publications

References 36 publications

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Research Progress of Disulfide Bond Based Tumor Microenvironment Targeted Drug Delivery System

Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer

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