Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents

Abstract

BackgroundCaries (dental decay) is a disease of the hard tissues of the teeth caused by an imbalance, over time, in the interactions between cariogenic bacteria in dental plaque and fermentable carbohydrates (mainly sugars). The use of fluoride toothpaste is the primary intervention for the prevention of caries. ObjectivesTo determine the relative effectiveness of fluoride toothpastes of different concentrations in preventing dental caries in children and adolescents, and to examine the potentially modifying effects of baseline caries level and supervised toothbrushing. Search methodsA search was undertaken on Cochrane Oral Health Group's Trials Register, CENTRAL, MEDLINE and several other databases. Reference lists of articles were also searched.Date of the most recent searches: 8 June 2009. Selection criteriaRandomised controlled trials and cluster-randomised controlled trials comparing fluoride toothpaste with placebo or fluoride toothpaste of a different concentration in children up to 16 years of age with a follow-up period of at least 1 year. The primary outcome was caries increment in the permanent or deciduous dentition as measured by the change in decayed, (missing), filled tooth surfaces (D(M)FS/ d(m)fs) from baseline. Data collection and analysisInclusion of studies, data extraction and quality assessment were undertaken independently and in duplicate by two members of the review team. Disagreements were resolved by discussion and consensus or by a third party. The primary effect measure was the prevented fraction (PF), the caries increment of the control group minus the caries increment of the treatment group, expressed as a proportion 1 Fluoride toothpastes of different concentrations for preventing dental caries in children and adolescents (Review)

School-based oral health education increases caries inequalities

“…Students who received the intervention and were not brushing their teeth regularly at baseline had a significant decrease in risk of dental caries that reached up to 80% compared to the control group. This is in agreement with previous investigations showed the frequency of brushing to be an important risk indicator for caries in the primary and permanent dentition (Vanobbergen et al, 2004;Walsh et al, 2010).…”

School-based oral health education increases caries inequalities

“…Students who received the intervention and were not brushing their teeth regularly at baseline had a significant decrease in risk of dental caries that reached up to 80% compared to the control group. This is in agreement with previous investigations showed the frequency of brushing to be an important risk indicator for caries in the primary and permanent dentition (Vanobbergen et al, 2004;Walsh et al, 2010).…”

Fluoride Dose-Response and Anticaries Effect of Herbal Antibacterial Agents and (Nano-)Hydroxyapatite on Dentin Caries: An in vitro Study

“…A significant (very) strong correlation between mineral change (∆∆Z) as well as lesion depth (∆LD) and fluoride concentration (0–1,100 ppm F − ) was observed for both baseline substrate conditions, confirming the first hypothesis. This fluoride dose-response aligns with previous findings in both enamel [27] and dentin [28] studies, where fluoride’s ability to inhibit demineralization and enhance remineralization has been demonstrated in vivo [27, 28], in situ [14, 29, 30], and in vitro [4, 5, 7]. Conversely, the second hypothesis was partially rejected as no significant difference in the change of mineral loss was observed between the regular fluoride-free dentifrice and those containing nHA or (herbal) antibacterial agents, such as propolis and fennel extracts, curcuma, and clove extracts.…”

Influence of highly concentrated fluoride dentifrices on remineralization characteristics of enamel in vitro

“…This was also reflected by the significant correlation between F − concentration and ΔΔZ. On the one hand, this is in agreement with the re-and demineralization characteristics being observed in vivo [2,24] and in situ [19,20,25]. On the other hand, this seems to be in contrast to a similar in vitro study [11].…”

School-based oral health education increases caries inequalities

“…Students who received the intervention and were not brushing their teeth regularly at baseline had a significant decrease in risk of dental caries that reached up to 80% compared to the control group. This is in agreement with previous investigations showed the frequency of brushing to be an important risk indicator for caries in the primary and permanent dentition (Vanobbergen et al, 2004;Walsh et al, 2010).…”

Fluoride Dose-Response and Anticaries Effect of Herbal Antibacterial Agents and (Nano-)Hydroxyapatite on Dentin Caries: An in vitro Study

“…A significant (very) strong correlation between mineral change (∆∆Z) as well as lesion depth (∆LD) and fluoride concentration (0–1,100 ppm F − ) was observed for both baseline substrate conditions, confirming the first hypothesis. This fluoride dose-response aligns with previous findings in both enamel [27] and dentin [28] studies, where fluoride’s ability to inhibit demineralization and enhance remineralization has been demonstrated in vivo [27, 28], in situ [14, 29, 30], and in vitro [4, 5, 7]. Conversely, the second hypothesis was partially rejected as no significant difference in the change of mineral loss was observed between the regular fluoride-free dentifrice and those containing nHA or (herbal) antibacterial agents, such as propolis and fennel extracts, curcuma, and clove extracts.…”

Influence of highly concentrated fluoride dentifrices on remineralization characteristics of enamel in vitro

“…This was also reflected by the significant correlation between F − concentration and ΔΔZ. On the one hand, this is in agreement with the re-and demineralization characteristics being observed in vivo [2,24] and in situ [19,20,25]. On the other hand, this seems to be in contrast to a similar in vitro study [11].…”

School-based oral health education increases caries inequalities

“…Students who received the intervention and were not brushing their teeth regularly at baseline had a significant decrease in risk of dental caries that reached up to 80% compared to the control group. This is in agreement with previous investigations showed the frequency of brushing to be an important risk indicator for caries in the primary and permanent dentition (Vanobbergen et al, 2004;Walsh et al, 2010).…”

Fluoride Dose-Response and Anticaries Effect of Herbal Antibacterial Agents and (Nano-)Hydroxyapatite on Dentin Caries: An in vitro Study

“…A significant (very) strong correlation between mineral change (∆∆Z) as well as lesion depth (∆LD) and fluoride concentration (0–1,100 ppm F − ) was observed for both baseline substrate conditions, confirming the first hypothesis. This fluoride dose-response aligns with previous findings in both enamel [27] and dentin [28] studies, where fluoride’s ability to inhibit demineralization and enhance remineralization has been demonstrated in vivo [27, 28], in situ [14, 29, 30], and in vitro [4, 5, 7]. Conversely, the second hypothesis was partially rejected as no significant difference in the change of mineral loss was observed between the regular fluoride-free dentifrice and those containing nHA or (herbal) antibacterial agents, such as propolis and fennel extracts, curcuma, and clove extracts.…”

Influence of highly concentrated fluoride dentifrices on remineralization characteristics of enamel in vitro

“…This was also reflected by the significant correlation between F − concentration and ΔΔZ. On the one hand, this is in agreement with the re-and demineralization characteristics being observed in vivo [2,24] and in situ [19,20,25]. On the other hand, this seems to be in contrast to a similar in vitro study [11].…”