Fluoride toothpaste supplemented with sodium hexametaphosphate reduces enamel demineralization in vitro

Camara, Danielle Mendes da; Pessan, Juliano Pelim; Francati, Tamires Melo; Souza, José Antônio Santos; Danelon, Marcelle; Delbem, Alberto Carlos Botazzo

doi:10.1007/s00784-015-1707-x

Cited by 30 publications

(34 citation statements)

References 26 publications

(45 reference statements)

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“…When used at high concentrations, SMTP has the ability to supersaturate the enamel surface and further sequester Ca 2+ from hydroxyapatite due to its strong ability to complex metal ions, resulting in mineral loss [da Camara et al, 2016]. Although this evidence was reported for enamel, a similar mechanism is expected for dentin.…”

Section: Discussionmentioning

confidence: 88%

“…5c). It can be speculated that the addition of high concentrations of STPM to the medium may have supersaturated the dentin tissue, leading to sequestration of Ca 2+ from the dentin [Anbar et al, 1979;Changgen and Yongxin, 1983;da Camara et al, 2016]. Supposedly, the concentrations of 3.5 and 5% were able to decrease the Ca/P ratio of these groups, since this is the main reason of calcium loss, which impaired remineralization.…”

Section: Discussionmentioning

confidence: 99%

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Sodium Trimetaphosphate as a Novel Strategy for Matrix Metalloproteinase Inhibition and Dentin Remineralization

Gonçalves

Scaffa²,

Giacomini³

et al. 2018

Caries Res

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The effect of sodium trimetaphosphate (STMP) as an antiproteolytic and remineralizing agent on demineralized dentin was evaluated in vitro. The inhibitory potential of STMP at 0.5, 1.5, 3.5, and 5% against recombinant matrix metalloproteinases (MMPs) MMPs-2 and -9 was assessed by zymography. To investigate its remineralization potential, 40 bovine root specimens were obtained and subjected to a demineralization protocol to produce caries-like dentin lesions. After that, dentin surfaces were divided into 3 areas: (1) mineralized (no treatment); (2) demineralized; and (3) demineralized/treated with STMP and submitted to a pH-cycling associated or not with STMP (1.5, 3.5, or 5% STMP, 10 min of treatment). After that, superficial hardness (SH) and cross-sectional hardness (CSH) were determined. Polarized light microscopy (PLM) was used to qualitatively evaluate mineralization within the caries-like lesions. The zymographic analysis showed that STMP solution is a potent inhibitor of the gelatinolytic activity of MMPs-2 and -9 depending on the dose, since the lowest concentration (0.5%) partially inhibited the enzyme activity, while the higher concentrations completely inhibited enzyme activity. Regarding remineralization effect, only 1.5% STMP solution enhanced both the SH and CSH. PLM showed that the area treated with 1.5% STMP presented similar birefringence as mineralized sound dentin. In conclusion, 1.5% STMP solution is effective as an antiproteolytic agent against MMPs and promotes dentin remineralization.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Sodium Trimetaphosphate as a Novel Strategy for Matrix Metalloproteinase Inhibition and Dentin Remineralization

Gonçalves

Scaffa²,

Giacomini³

et al. 2018

Caries Res

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“…One way to reduce the potential risk of fluorosis while maintaining the anticaries efficacy of conventional dentifrices is to partly replace fluoride with polyphosphate salts like sodium trimetaphosphate (STMP), calcium glycerophosphate, or hexametaphosphate [da Camara et al, 2016;Takeshita et al, 2016;Zaze et al, 2014]. Among the polyphosphates, STMP is seen to be the most effective anticaries agent with an ability to not only inhibit demineralization, but also to enhance remineralization [Freire et al, 2016;Takeshita et al, 2011].…”

Section: Fluoride Boostersmentioning

confidence: 99%

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

2018

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The principles of minimally invasive dentistry clearly dictate the need for clinically effective measures to remineralize early enamel caries lesions. While fluoride-mediated remineralization is the cornerstone of current caries management philosophies, a number of new remineralization strategies have been commercialized or are under development that claim to promote deeper remineralization of lesions, reduce the potential risks associated with high-fluoride oral care products, and facilitate caries control over a lifetime. These non-fluoride remineralizing systems can be broadly categorized into biomimetic enamel regenerative technologies and the approaches that repair caries lesions by enhancing fluoride efficacy. This paper discusses the rationale for non-fluoride remineralization and the mechanism of action, challenges, and evidence behind some of the most promising advances in enamel remineralization therapies.

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“…As HMP associated to 1,100 ppm F did not enhance enamel F uptake [Dalpasquale et al, 2017;da Camara et al, 2015;da Camara et al, 2016], the superior results with nano-sized HMP is probably due to the higher reactivity of these particles [Dalpasquale et al, 2017]. Given that the anticaries effect of fluoride toothpastes (i.e., without HMP/HMPnano) is usually related to the ability to increase enamel fluoride concentrations, it can be concluded that the mechanism of action of HMP/ HMPnano containing fluoride toothpastes is somehow different from products containing fluoride only.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the development of new toothpaste formulations to enhance anticaries effects has been investigated; formulations include the addition of inorganic phosphate salts Takeshita et al, 2015;Danelon et al, 2017]. Among these, micrometric sodium hexametaphosphate (HMP) has a strong affinity to the enamel surface because of multiple binding sites, resulting in a reduced mineral loss when associated with fluoride as demonstrated by da Camara et al [2014;2016].…”

Section: Introductionmentioning

confidence: 99%

Effect of Fluoride Toothpaste Containing Nano-Sized Sodium Hexametaphosphate on Enamel Remineralization: An in situ Study

et al. 2018

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Objective: To evaluate the remineralizing potential of a conventional toothpaste (1,100 ppm F) supplemented with nano-sized sodium hexametaphosphate (HMPnano) in artificial caries lesions in situ. Design: This double-blinded crossed study was performed in 4 phases of 3 days each. Twelve subjects used palatal appliances containing 4 bovine enamel blocks with artificial caries lesions. Volunteers were randomly assigned into the following treatment groups: no F/HMP/HMPnano (Placebo); 1,100 ppm F (1100F); 1100F plus 0.5% micrometric HMP (1100F/HMP) and 1100F plus 0.5% nano-sized HMP (1100F/HMPnano). Volunteers were instructed to brush their natural teeth with the palatal appliances in the mouth for 1 min (3 times/day), so that blocks were treated with natural slurries of toothpastes. After each phase, surface hardness post-remineralization (SH2), integrated recovery of subsurface hardness (ΔIHR), integrated mineral recovery (ΔIMR) and enamel F concentration were determined. Data were submitted to analysis of variance and Student-Newman-Keuls’ test (p < 0.001). Results: Enamel surface became 42% harder when treated with 1100F/HMPnano in comparison with 1100F (p < 0.001). Treatment with 1100F/HMP and 1100F/HMPnano promoted an increase of ∼23 and ∼87%, respectively, in ΔIHR when compared to 1100F (p < 0.001). In addition, ΔIMR for the 1100F/HMPnano was ∼75 and ∼33% higher when compared to 1100F and 1100F/HMP respectively (p < 0.001). Enamel F uptake was similar among all groups except for the placebo (p < 0.001). Conclusion: The addition of 0.5% HMPnano to a conventional fluoride toothpaste was able to promote an additional remineralizing effect of artificial caries lesions.

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Fluoride toothpaste supplemented with sodium hexametaphosphate reduces enamel demineralization in vitro

Abstract: This dentifrice could potentially be indicated to patients at high risk of caries.

Cited by 30 publications

References 26 publications

Sodium Trimetaphosphate as a Novel Strategy for Matrix Metalloproteinase Inhibition and Dentin Remineralization

Sodium Trimetaphosphate as a Novel Strategy for Matrix Metalloproteinase Inhibition and Dentin Remineralization

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

Effect of Fluoride Toothpaste Containing Nano-Sized Sodium Hexametaphosphate on Enamel Remineralization: An in situ Study

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