Fluoride therapy for osteoporosis: Characterization of the skeletal response by serial measurements of serum alkaline phosphatase activity

Farley, S. M.; Wergedal, Jon E.; Smith, Lynna C.; Lundy, Mark W.; Farley, John R.; Baylink, David J.

doi:10.1016/0026-0495(87)90178-8

Cited by 61 publications

(16 citation statements)

References 19 publications

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“…Indeed, the effective Ag + incorporation within apatite lattice was testified by the identification of CaO, whose formation was ascribed to the oxidation of the free Ca 2+ ions, available in consequence of Ag + substitution for Ca 2+ within apatite lattice, during the thermal treatments [141]. Yang et al reported the formation of silver orthophosphate [199], and Sygnatowicz et al [162] detected silver phosphate phases and metallic silver, whose presence was also identified by Díaz et al [196] who synthesized Ag-HAp by a colloidal chemical route and a subsequent treatment in H 2 /Ar atmosphere at 350 C with consequent reduction of the Ag + cations to elemental silver.…”

Section: Synthesis Of Ag-substituted Hapmentioning

confidence: 77%

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Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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Section: Synthesis Of Ag-substituted Hapmentioning

confidence: 77%

“…Moreover fluoride is considered as an important therapeutic agent in the osteoporosis treatment [348] and has been widely and successfully employed for this application [349][350][351][352][353][354].…”

Section: Fluoride Substitutionmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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“…It has been used as a valuable marker enzyme of odontoblast-like cells in vitro [30,31], as well as bone-cells [32]. Our subcultured cells expressed ALP activity which was inhibited in a dosedependent manner by F. Sodium fluoride is widely used in the treatment of osteoporosis and one of the responses to F treatment is an increase of the serum ALP activity [33,34]. Farley et al [35] demonstrated that low concentrations of F (about 0.2 ppm) induced an increased ALP activity in exposed calvaria cells and the same results were obtained by Wergedal et al [36] on human bone cells.…”

Section: Alkaline Phosphatase Activitymentioning

confidence: 91%

Selective inhibition of collagen synthesis by fluoride in human pulp fibroblastsIn Vitro

1993

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Human dental pulp cells were cultured in fluoridated mediums (0, 1, 10, 25 ppm) in order to study the biological effect of the ion regarding the cellular metabolism: cell growth, alkaline phosphatase (ALP) activity, and protein synthesis. The results indicated a decrease of the cell growth at 25 ppm and a dose-dependent decrease of the ALP activity. Type I collagen immunoperoxidase staining, radioimmunoassay quantitation, and analysis of type I and III collagens mRNA levels showed an inhibition of collagen production and gene expression. In contrast, fibronectin production and gene expression were not affected by fluoride. The treatment did not influence the qualitative pattern of the different mRNA species. Of the three collagen chains, the alpha 1(I) was the most affected. These data suggest that fluoride does not exert a general depletive effect on human dental pulp cells but rather a selective inhibition on collagen production.

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“…Additionally, F intake has been considered to affect bone crystal structure and change bone mineral content during mineralization, leading to more acid resistant fluorapatite crystals to bone resorption. Because of this belief, until recently NaF was used to treat osteoporosis [20][21][22][23][24][25][26] . To address these controversial issues, we designed the present study to directly verify whether the damaged crystals were actually repaired and whether the replacement of OH with F ions occurs.…”

Section: Introductionmentioning

confidence: 99%

Aspects Regarding Fluoride Treatment for Reinforcement and Remineralization of Apatite Crystals

Kakei

Tanaka

Yoshikawa

2012

J. Hard Tissue Biology.

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The purpose of the present study was to investigate whether fluoride (F) ions are really capable of the repair (remineralization) of damaged crystals and useful for reinforcing the quality (i.e. modify the crystal structure) of tooth enamel using transmission electron microscopy and Raman microprobe analysis. Additionally, carbonic anhydrase activity was measured in immature enamel tissue to compare the harmfulness of F ions to that of cadmium (Cd) ions during the process of crystal nucleation by means of differential gas pressure analysis. Electron micrographs indicated no signs of remineralization of artificially damaged crystals after incubation in a remineralizing solution and further revealed that treatment with acidulated phosphate fluoride (APF) gel caused crystal dissolution rather than crystal improvement. Regarding crystal structure modification, Raman microprobe analysis revealed that no up-shift of PO 4 3-ν 1 band assigned to human sound enamel crystals occurred when APF gel was used. Furthermore, fluorapatite crystals were not generated by daily intake of F ions in developing rat tooth enamel. A differential gas pressure method demonstrated that the harmfulness of F exposure during the nucleation process of calcified hard tissues was much greater than that of Cd exposure. These results demonstrate that F treatments have no effect on improving crystal quality or remineralization and are inconsistent with the purpose of public health.

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Fluoride therapy for osteoporosis: Characterization of the skeletal response by serial measurements of serum alkaline phosphatase activity

Cited by 61 publications

References 19 publications

Cationic and Anionic Substitutions in Hydroxyapatite

Cationic and Anionic Substitutions in Hydroxyapatite

Selective inhibition of collagen synthesis by fluoride in human pulp fibroblastsIn Vitro

Aspects Regarding Fluoride Treatment for Reinforcement and Remineralization of Apatite Crystals

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