Fluoride intake and urinary fluoride excretion in 4‐ and 8‐year‐old children living in urban and rural areas of Southwest Nigeria

Ibiyemi, Olushola; Zohoori, Fatemeh; Valentine, Ruth; Maguire, Anne

doi:10.1111/cdoe.12396

Cited by 14 publications

(15 citation statements)

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“…During visit 1, the weight of each child was measured without shoes and jacket to the nearest 0.1 kg using a portable digital balance (Seca 803; Seca, Germany). The parents were interviewed to collect demographic information and their children's oral hygiene habits, including the type of toothpaste used regularly (if their children brushed) and frequency of brushing per day, using a validated questionnaire [Levy and Zarei-M, 1991;Ibiyemi et al, 2018]. A validated food frequency questionnaire [Levy and Zarei-M, 1991;Ibiyemi et al, 2018] was also administered to estimate fluoride intake from the diet.…”

Section: Data and Sample Collectionmentioning

confidence: 99%

“…The parents were interviewed to collect demographic information and their children's oral hygiene habits, including the type of toothpaste used regularly (if their children brushed) and frequency of brushing per day, using a validated questionnaire [Levy and Zarei-M, 1991;Ibiyemi et al, 2018]. A validated food frequency questionnaire [Levy and Zarei-M, 1991;Ibiyemi et al, 2018] was also administered to estimate fluoride intake from the diet. To confirm the fluoride concentration of each child's home water supply, a sample was collected and analysed for fluoride.…”

Section: Data and Sample Collectionmentioning

confidence: 99%

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Biomarkers for the Assessment of Fluoride Exposure in Children

et al. 2020

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Due to practical difficulties in quantifying fluoride exposure, the ability of various biomarkers to predict it has been investigated previously. However, the results are inadequate for validation of their application and usefulness. This study aimed to investigate the association between contemporary/recent biomarkers of fluoride exposure and total daily fluoride intake (TDFI) of children with large differences in fluoride exposure through drinking water. TDFI was assessed in 61 healthy 4 to 5 years old children who provided at least one biomarker sample; 32 lived in a low-fluoride area (0.04 mgF/L) and 29 lived in a high-fluoride area (3.05 mgF/L). Validated questionnaires were administered to evaluate fluoride intake from diets (including water) and toothpaste ingestion. Daily urinary fluoride excretion (UFE) as well as fluoride concentrations in plasma, fasting whole saliva, hair and nails (toenails/fingernails) were evaluated and related to total fluoride exposure. TDFI, UFE and fluoride concentration of biomarkers were statistically significantly higher in the high-fluoride area than in the low-fluoride area. There was a strong statistically significant positive correlation between TDFI and: UFE (ρ=0.756, p<0.001); plasma fluoride concentration (ρ=0.770, p<0.001); toenail fluoride concentration (ρ=0.604, p<0.001). The statistically significant positive correlation between TDFI and fingernail fluoride concentration (ρ=470, p<0.001) as well as between TDFI and fasting whole saliva fluoride concentration (ρ=0.453, p=0.001) was moderate, whereas it was weak between TDFI and hair fluoride concentration (ρ=0.306, p=0.027). In conclusion, the current study confirmed the suitability of 24h urine samples for estimating F exposure in children. The strong correlations between TDFI and F in plasma and toenails also suggest these biomarkers may be considered for health risk assessments of fluoride in children who are susceptible to development of dental fluorosis. Sample preparation and analysis Urine samples collected over the 24h period were pooled for each participant, and the total volume was measured. Saliva samples were centrifuged at 1000 rpm (MSE Harrier 18/80, UK) for 2 min to separate any food debris [Martínez-Mier et al., 2011]. Each blood sample was centrifuged for 10 min at 1500 rpm and the plasma collected. Nail samples from each participant (finger-and toenails , separately) were weighed, and then surface contamination from the nail clippings was removed by sonication in distilled water for 15 min [Whitford, 2005]. The cleaned samples were dried at 95ºC and weighed again. Food samples were weighed and then homogenised using an industrial blender (Cookwork BL9292, UK). Water and urine samples were analysed directly using a F ion selective electrode (ISE, 720A series; Orion Research Inc., Boston, MA, USA) after addition of TISAB III [Martínez-Mier et al., 2011]. Food, toothpaste, plasma, whole saliva, hair and nail samples were analysed after overnight hexamethyldisiloxane-acid diffusion [Martínez-Mier et a...

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Section: Data and Sample Collectionmentioning

confidence: 99%

Section: Data and Sample Collectionmentioning

confidence: 99%

Biomarkers for the Assessment of Fluoride Exposure in Children

et al. 2020

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“…La ingesta para residentes con una dieta de maíz tostado y chile tostado fue de 5,06; 9,60 edad 3-7, 8-15 y para el mismo grupo de edad que se alimentan de arroz y chile asado fue de 1,94; 3,50 y 4,95 mg (Li et al, 2015). Por lo contrario podemos mencionar la ingesta de fluoruro en estos nigerianos de 4 y 8 años de edad fue mucho más alta que el "rango óptimo" de 0,05-0,07 mg / kg pc / d (Ibiyemi et al, 2018), así mismo, que la media 14,38 mg para los grupos de edad más de 15 años (Li et al, 2015). En la tabla 3 se observa el contenifo del iones de flúor en las aguas potables de las zonas rurales en estudio y las aguas minerales embotelladas que están comerlizadas para zonara rural de Lamud Luya se encuentra en rango medio, Lunahuana rango bajo, A.M.B (A) y (B) rango óptmo, A.M.B (C) y (D) rango bajo (Ministerio de Salud Pública del Ecuador, 1997) por lo contrario podemos mencionar que hay una alta concentración de fluoruro en el agua potable en ciertas localidades de Punjab rural (Plaka et al, 2017).…”

Section: Resultados Y Discusiónunclassified

Fluorine intake in foods and oral health indicators in students from two rural areas of Peru

Sánchez-Chávez-Arroyo¹,

Robles²,

Sánchez-Chávez-Arroyo³

et al. 2019

CpD

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“…Review of data (Table 1) reveals that the contribution of fluoride with the toothpaste in nonfluoridated and fluoridated areas is substantial and represents about half of the estimated average total intake and that the estimates for the total daily intake of fluoride in some studies exceed Štepec and Ponikvar-Svet: Fluoride in Human Health and Nutrition the AI in both nonfluoridated and fluoridated areas. 30,[243][244][245][246][247][248][249][250][251] The average estimated daily intake of fluoride in nonfluoridated areas is higher and in fluoridated areas lower, than that reported with diet and toothpaste a decade ago (0.036 and 0.071 mg/kg body weight in nonfluoridated and fluoridated areas, respectively). 23 Possible explanations for these differences are that the recent research (Table 1) has been more focused on: (1) the actual intakes of fluoride, as determined by duplicate diet technique; (2) the total oral fluoride intake including actual intake of fluoride with the toothpaste; and (3) the use of more accurate and precise analytical methods for total fluorine determination.…”

Section: Fluoridated Salt or Milk And Fluoride Supplementsmentioning

confidence: 99%

Fluoride in Human Health and Nutrition

Štepec

Ponikvar‐Svet

2019

ACSi

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Fluorine is in the form of fluorides ubiquitous in nature and as such an inevitable part of our environment. In small amounts, it is known to have beneficial effects on dental health. On the other hand, excessive chronic intakes can result in adverse effects including the development of dental fluorosis in children and/or skeletal fluorosis in both children and adults. The adequate intake has been set, based on empirical observations, at 0.05 mg/day/kg body weight however, the threshold between beneficial and harmful effects is narrow. Despite numerous studies, knowledge on the fluoride toxicity is still relatively poor. In this review, the role and the effects of fluoride on human health are enlightened. Some of the fluoride controversies are discussed and future research directions suggested.

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Fluoride intake and urinary fluoride excretion in 4‐ and 8‐year‐old children living in urban and rural areas of Southwest Nigeria

Cited by 14 publications

References 30 publications

Biomarkers for the Assessment of Fluoride Exposure in Children

Biomarkers for the Assessment of Fluoride Exposure in Children

Fluorine intake in foods and oral health indicators in students from two rural areas of Peru

Fluoride in Human Health and Nutrition

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