Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes

Zhao, Yangfei; Li, Yanyan; Wang, Jinming; Manthari, Ram Kumar

doi:10.1007/s00204-018-2305-x

Cited by 60 publications

(29 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies revealed that the height and weight of children in F-contaminated areas were signi cantly lower than those in normal areas [14]. Recent works using animal models reported that rats or mice exposed to super uous F could experience a signi cant reduction in weight and organ coe cient of liver [15,16]. This corroborates with our results, which shows that the weight gain of mice exposed to 50 mg/L NaF for 90 days signi cantly differs from the control group, indicating that excessive F exposure causes an adverse effect on the growth performance of mice.…”

Section: Discussionmentioning

confidence: 99%

IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis

Zhao

Wang

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Backgroud Reproductive toxicity of fluoride (F) has been verified by epidemiological and experimental investigations. Based on the literature and our recent studies, as well as the reports inferred by sequencing analysis of mice with normal and fluorosis testes, it is suggested that the interleukin 17A (IL-17A) signaling pathway may be the key link of the damage in testes of the fluorosis animals. To investigate the role of IL-17A in the process of F-induced testicular injury, we exposed wild type (WT) genotype mice and IL-17A knockout (IL-17A-/-) genotype mice to 50mg/L Sodium fluoride (NaF) at 90 days, respectively.Results From the results, we verified IL-17A played a key role in the exacerbation of testicular injuries in fluoride-exposed animals, and found IL-17A knockdown could evidently ameliorate the lesion of testicular damage, including the improves in semen quality,maintain testicular morphology and reducing the immune response in testis. In addition, our results showed that Leydig cells exposed to NaF and recombinant IL-17A in vitro displayed both abnormal apoptoses and decreased secretions of testosterone.Conclusions Altogether, our findings proved that IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis. This study also provides the mechanism of reproductive toxicity of F, the basis for scientific diagnosis, and possible target drug design.

show abstract

Section: Discussionmentioning

confidence: 99%

IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis

Zhao

Wang

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The results indicate that HIF-1α signaling pathway plays an important role in the regulation of TNF-α-induced proliferation and metastasis of A549 cells in NSCLC [59]. In addition, there are five other pathways: p53 signaling pathway [60,61], cellcycle, ErbB signaling pathway [62], IL-17 signaling pathway [51,52,63,64], small cell lung cancer, vascular endothelial growth factor signaling pathway [65,66]. All of them are closely related to the occurrence of lung cancer, apoptosis of tumor cells, and immune function.…”

Section: Pathway Analysis Of Xqd Acting On Lc Therapeutic Targetsmentioning

confidence: 91%

Network Pharmacology Approach Reveals the Potential Immune Function Activation and Tumor Cell Apoptosis Promotion of Xia Qi Decoction in Lung Cancer

Zhang

Wang

2019

Medical Sciences

View full text Add to dashboard Cite

As the leading cause of cancer death worldwide, lung cancer (LC) has seriously affected human health and longevity. Chinese medicine is a complex system guided by traditional Chinese medicine theories (TCM). Nowadays, the clinical application of TCM for LC patients has become the focus for its effectiveness and security. In this paper, we will analyze and study the mechanism of Xia Qi Decoction (XQD) in the treatment of LC. The results collectively show that XQD could act on 41 therapeutic targets of LC. At the same time, 8 of 41 targets were significantly expressed in immune tissues and cells by activating CD8+T cells to promote apoptosis of cancer cells. It reveals the molecular mechanism of XQD in the treatment of LC from the perspective of network pharmacology. In addition, in the treatment of LC, XQD can activate (up-regulate) the function of immune cells, promote the apoptosis of tumor cells, and have an active anti-tumor immune effect. In conclusion, this study reveals the unique advantages of traditional Chinese medicine in the treatment of cancer, in reinforcing the healthy qi and eliminating the pathogenic factors. More research, however, is needed to verify the potential mechanisms.

show abstract

“…Interleukin-17 in the IL-17 signaling pathway plays a crucial role in acute and chronic inflammatory responses (Zhao, Li, Li, Wang, Manthari, & Wang, 2018). Interleukin-17 in the IL-17 signaling pathway plays a crucial role in acute and chronic inflammatory responses (Zhao, Li, Li, Wang, Manthari, & Wang, 2018).…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

“…additional evidence that GABAergic dysfunction may lead to mood and cognitive symptoms of MDD. Interleukin-17 in the IL-17 signaling pathway plays a crucial role in acute and chronic inflammatory responses (Zhao, Li, Li, Wang, Manthari, & Wang, 2018). Neuroendocrine and immune system interactions play an important role in stress response (Ashley & Demas, 2017;Dantzer, 2018).…”

Section: Ta B L E 1 (Continued)mentioning

confidence: 99%

Analyzing the genes and pathways related to major depressive disorder via a systems biology approach

et al. 2019

View full text Add to dashboard Cite

Introduction:Major depressive disorder (MDD) is a mental disorder caused by the combination of genetic, environmental, and psychological factors. Over the years, a number of genes potentially associated with MDD have been identified. However, in many cases, the role of these genes and their relationship in the etiology and development of MDD remains unclear. Under such situation, a systems biology approach focusing on the function correlation and interaction of the candidate genes in the context of MDD will provide useful information on exploring the molecular mechanisms underlying the disease. Methods:We collected genes potentially related to MDD by screening the human genetic studies deposited in PubMed (https ://www.ncbi.nlm.nih.gov/pubmed). The main biological themes within the genes were explored by function and pathway enrichment analysis.Then, the interaction of genes was analyzed in the context of protein-protein interaction network and a MDD-specific network was built by Steiner minimal tree algorithm. Results:We collected 255 candidate genes reported to be associated with MDD from available publications. Functional analysis revealed that biological processes and biochemical pathways related to neuronal development, endocrine, cell growth and/or survivals, and immunology were enriched in these genes. The pathways could be largely grouped into three modules involved in biological procedures related to nervous system, the immune system, and the endocrine system, respectively. From the MDD-specific network, 35 novel genes potentially associated with the disease were identified. Conclusion:By means of network-and pathway-based methods, we explored the molecular mechanism underlying the pathogenesis of MDD at a systems biology level. Results from our work could provide valuable clues for understanding the molecular features of MDD. K E Y W O R D Smajor depressive disorder, network analysis, pathway cross talk 2 of 16 | FAN et Al.

show abstract

Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes

Cited by 60 publications

References 57 publications

IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis

IL-17A deficiency alleviate fluoride-induced injury by inhibiting immune response and apoptosis in testis

Network Pharmacology Approach Reveals the Potential Immune Function Activation and Tumor Cell Apoptosis Promotion of Xia Qi Decoction in Lung Cancer

Analyzing the genes and pathways related to major depressive disorder via a systems biology approach

Contact Info

Product

Resources

About