Fluoride-induced disruption of reproductive hormones in men

The effect of non-fluoride factors on risk of dental fluorosis: Evidence from rural populations of the Main Ethiopian Rift

“…DF is the most widespread and long-recognized health effect of F − exposure. However, F − also may cause damages to other organs and systems: for example, skeletal fluorosis (Edmunds and Smedley, 2005) that is characterized by the thickening and increased density of bones, thyroid dysfunction (resulting in slower mental development and lower IQ in children) (Ding et al, 2011) (Xiang et al, 2003), dysfunction of reproductive system (leading to infertility, especially in males due to oligo-or azoospermia and, probably, lower testosterone level) (Chinoy and Narayana, 1994;Ortiz-Pérez et al, 2003), developmental defects in fetuses (GUPTA et al, 1995;Takahashi, 1998), and gastrointestinal problems (nausea, stomach pain, intermittent diarrhea, and flatulence) (Dasarathy et al, 1996). We conducted a study of dental health outcomes among randomly selected households living in several communities of the MER of Ethiopia; our focus on DF was motivated by the fact that it is the most widespread and easily diagnosed condition that can be observed in populations consuming water with excessive F − concentration.…”

Removal of fluoride from aqueous media by Fe3O4@Al(OH)3 magnetic nanoparticles

“…According to World Health Organization (WHO) norms, the upper limit of fluoride concentration in drinking water is 1.5 mg L −1 [3]. Long-term ingestion of high-fluoride drinking water can cause fluorosis [4,5], which is a chronic disease manifested by mottling of teeth in mild cases, softening of bones ossification of tendons and ligaments and neurological damage in severe cases [2,6]. Millions of people in the world are affected by fluorosis, especially in Asian countries such as China, India, Pakistan, and Thailand [6][7][8].…”

Fluoridation and hypothyroidism – a commentary on Peckham et al.

“…Significant correlation was observed between urinary fluoride and serum concentrations of inhibin-B (p<0.028). No abnormalities were found in the semen parameters in either the high-or low-fluoride exposure groups (Ortiz-Pérez et al 2003). The alteration in the reproductive hormone levels after occupational fluoride exposure is not relevant for drinking water exposure.…”