Fluoride incorporation into developing enamel of permanent teeth in the domestic pig

Speirs, R.L.

doi:10.1016/0003-9969(75)90070-9

Cited by 32 publications

(9 citation statements)

References 12 publications

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“…Since the human tooth continues to develop postnatally, the pattern of fluoride distribution throughout the full spectrum of enamel development in this tooth is, there fore, still to be established. However, the pattern of fluoride distribution that appears to emerge from those 7 human fetal teeth available for analysis seems to be somewhat similar, in the comparable stages of devel opment, to that reported in studies of devel oping rat and bovine [Weatherell et al, 1975] and pig incisors [Speirs, 1975[Speirs, ,1978a. As in these previous reports, the fluoride concentrations in the human teeth fell as the partially mineralized enamel increased in thickness during the period of matrix secre tion.…”

Section: Discussionsupporting

confidence: 78%

“…However, because of the lack of microanalytical methods and because of the very ob vious difficulty in obtaining developing hu man teeth, very little is known about fluo ride incorporation and distribution in devel oping human enamel. This information is important since fluoride might exert part of its effect on the caries susceptibility of teeth during the period of enamel development [Jenkins, 1970], It is also during this period of formation and mineralization that fluo ride can bring about the changes associated with dental fluorosis [Hodge, 1963;Weath ered, 1966], Fluoride distribution in the developing enamel of various animal species has already been described [Weathered et ah, 1975;Speirs, 1975;Ahlbergetah, 1975], and it is clearly important to establish whether a similar pattern exists in the human enamel.…”

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confidence: 99%

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Fluoride Concentration in Human Fetal Enamel

Deutsch

Gedalia

1982

Caries Res

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The fluoride distribution was determined along the developing human fetal enamel of 7 maxillary first incisors taken from fetuses aged 5–9 months. The fluoride concentration in the enamel from teeth of fetuses aged 5–8 months, which contained only forming enamel was higher in the youngest enamel near the cervical margin than in the earliest formed enamel at the incisal tip. In the developing enamel from the teeth of the 9-month-old fetuses, however, after the initial decrease in fluoride concentration from the cervical margin towards the border between the forming stage and the maturing stage, there was a rise in fluoride concentration as the forming enamel began to rapidly mineralize to become maturing enamel. This pattern seems analogous in the comparable stages of enamel development to that previously observed in developing enamel from teeth of experimental animals.

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Section: Discussionsupporting

confidence: 78%

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confidence: 99%

Fluoride Concentration in Human Fetal Enamel

Deutsch

Gedalia

1982

Caries Res

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“…At this age the enamel of the central incisor is fully formed [Mossier and Schour, 1958], and re cent studies indicate that fluoride may influ ence the matrix very early in the develop ment of the enamel rather than after its formation. Experiments have shown a surprisingly great uptake of fluoride in the newly formed matrix before significant amounts of mineral have been laid down [Hammarstrom, 1971;Speirs, 1975;Weath ered et al, 1975], In animals with high lev els of fluoride in the matrix, greater amounts of protein are retained in the mi neralized enamel [Ahlberg et al, 1976]. This finding parallels the observation that mottled enamel in humans is higher in pro tein than normal enamel [Bhussry, 1959;Thylstrup, 1979], suggesting that fluoridematrix interaction is similar in human teeth.…”

Section: Results and Commentsmentioning

confidence: 99%

A Preliminary Study of Posteruptive Maturation of Teeth in situ

Brudevold¹,

Aasenden²,

Bakhos³

1982

Caries Res

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A method for in vivo measurements of the permeability of surface enamel was applied to the central maxillary incisor of two groups of children ranging in age from 7 to 9 and 13 to 14 years, respectively. The method involved exposure of a standard area of the surface enamel to 2 M KI, removal of the iodide present on the surface, and determination of back diffusion of the imbibed iodide. The mean ( ± SE) of recovered iodide, expressed in mole equivalents × 10¹⁰, was 34.0 (5.9) for the younger group (n = 27) and 4.1 (1.3) for the older group (n = 32). The difference was statistically significant (p < 0.01). It is concluded that posteruptive maturation of enamel involves a decrease in permeability to iodide. The drinking water was fluoridated 4 years before the study was undertaken and possible effects of the waterborne fluoride on the findings are discussed.

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“…Proton activation (Ahlberg et al, 1975) and fluoride electrode measurements (Speirs, 1975; have shown a higher dry weight percentage of fluoride in secretory-stage enamel than in the later developmental stages. Based on gel filtration, equilibrium dialysis, and flow-rate dialysis studies using 18F, Crenshaw et al (1978) and Crenshaw and Bawden (1981) reported that the isolated organic matrix from bovine secretary enamel binds fluoride.…”

Section: Discussionmentioning

confidence: 99%

“…In several studies, a higher weight percentage of fluoride was found in the secretary stage enamel than in the maturation stage enamel (Ahlberg et al, 1975;Speirs, 1975;Weatherell et al, 1975Weatherell et al, , 1977. It has-been suggested that this additional fluoride in secretory-stage enamel is bound by the organic matrix (Crenshaw et al, 1978;Crenshaw and Bawden, 1981).…”

Section: Introductionmentioning

confidence: 99%

The in vitro Uptake of Fluoride by Secretory and Maturation Stage Bovine Enamel

et al. 1988

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The objectives of this study were to determine the specific surface area of secretory-stage and of maturation-stage enamel, to compare the fluoride uptake by isolated enamel at these two stages on a surface-area basis, and to examine the effect of the organic matrix on the fluoride uptake by whole enamel. Fetal bovine secretory and maturation stage enamel samples were collected, and a portion of the enamel at each developmental stage was treated with hydrazine for removal of the organic matrix. The specific surface areas of the enamel mineral, as determined by the multi-point BET method, were 59.3 m2/g in the secretory stage and 37.9 m2/g in the maturation stage. Whole and deproteinated enamel samples were equilibrated in buffered solutions containing 10(-5) to 10(-3) mol/L fluoride, and the uptake was measured with a fluoride specific electrode. The results indicate that the in vitro fluoride uptake was controlled solely by the surface area of the apatitic mineral and that the organic matrix did not contribute to the fluoride uptake.

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Fluoride incorporation into developing enamel of permanent teeth in the domestic pig

Cited by 32 publications

References 12 publications

Fluoride Concentration in Human Fetal Enamel

Fluoride Concentration in Human Fetal Enamel

A Preliminary Study of Posteruptive Maturation of Teeth in situ

The in vitro Uptake of Fluoride by Secretory and Maturation Stage Bovine Enamel

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