“…One important conclusion in the literature (Hammarstrom, 1971;Speirs, 1975;Weatherell et al, 1975a;Ahlberg et al, 1975;Deutsch and Gedalia, 1982) is that the maximum fluoride content of the enamel tissue is attained in the early developmental stages, and that it decreases as the density of the tissue (or mineralization) increases. Several investigators (Weatherell et al, 1975b;Crenshaw et al, 1978;Crenshaw and Bawden, 1981) have suggested that there is an association between fluoride and matrix proteins, and that some of the fluoride, as part of the matrix, might be withdrawn from the tissue during mineralization.…”