Fluoride distribution and histological structure of human cementum

Nakagaki, Haruo; Kawai, Kunihiro; Murakami, Taeko; Sakakibara, Yukitaro; Ohno, Nobutada; Weatherell, J.A.; Robinson, C.

doi:10.1016/0003-9969(88)90187-2

Cited by 26 publications

(10 citation statements)

References 15 publications

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“…Variations in fluoride concen tration across the tissue often produced a recogniz able profile. This generally appeared to be similar in the same type of tooth [Nakagaki et al, 1985], and tended to be characteristic of the patient from which the tooth had been extracted [Murakami et al, 1987], Nakagaki et al [1988] also demonstrated a relation ship between the fluoride distribution and the histo logical structure of the cementum.…”

Section: Introductionmentioning

confidence: 97%

Distribution of Fluoride across Cementum, Dentine and Alveolar Bone in Rats

et al. 1990

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This study was undertaken to determine the fluoride distribution in cementum and neighboring hard tissues of the rat after different levels of fluoride administration via the drinking water. Specimens of cementum with underlying dentine and adjacent bone were removed from the distal roots of the first lower molars. The fluoride distribution in each specimen was determined in samples removed sequentially using an abrasive microsampling technique. Fluoride concentrations were highest at or near the surface and decreased towards the interior of cementum, dentine and alveolar bone in both control and experimental groups. With increasing fluoride intake, concentrations increased throughout the tissue. The distribution patterns of fluoride in cementum of contralateral teeth from the same animal were similar. Fluoride concentrations in cementum were higher than those of dentine and alveolar bone.

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Section: Introductionmentioning

confidence: 97%

Distribution of Fluoride across Cementum, Dentine and Alveolar Bone in Rats

et al. 1990

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“…Nakagaki et al [1985] reported that the fluoride concen trations in human cementum were highest at or near the ce mentum surface and decreased towards the interior of the tissue, showing an occasional peak at the cementodentinal junction (CDJ). The distribution pattern o f the fluoride in human cementum, however, was determined by tooth type and the individual [Murakami et al, 1987], Nakagaki et al [1988] also demonstrated a relationship between fluoride distribution and histological structure. It was clear from these studies that the fluoride concentration in human ce mentum increases with age , In other reports it was suggested that the fluoride concentra tions in the cementum were also influenced by the fluoride concentrations in the drinking water [Yoon et al, 1960;Kato ct al., 1992], Human tooth samples, however, are frequently obtained from patients with periodontal disease.…”

Section: Introductionmentioning

confidence: 99%

Fluoride Distribution of Rat Molar Cementum in Relation to Age and Fluoride Levels in the Drinking Water

Kondo

Nakagaki²,

Kato³

et al. 1995

Caries Res

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The present study was undertaken to determine the fluoride distribution profile in rat molar cementum with age in relation to fluoride in drinking water. Fifty-four female Wistar rats were used for the experiment. Before the experiment 6 rats were killed under chloroform anesthesia at 4 weeks of age as controls. The remaining 48 rats were divided into two groups: a control group given distilled water and the other group given water containing 100 ppm fluoride ad libitum. Six rats from each group were killed at the ages of 6,12, 24, and 48 weeks. The fluoride distribution in the molar cementum was analyzed from the surface to the cementodentinal junction by abrasive microsampling. The fluoride concentrations in molar cementum from control rats on distilled water remained relatively constant until 24 weeks. A small increase then occurred between 24 and 48 weeks. The fluoride concentration in cementum from rats drinking water containing 100 ppm fluoride increased markedly with age, both in outer and inner regions of the molar cementum for all rats. On the other hand, the fluoride concentration in the cementum of older rats drinking water with 100 ppm fluoride was significantly higher in the outer than in the inner region of the cementum. It was concluded that the fluoride distribution in rat molar cementum may increase throughout life in relation to the fluoride level in the drinking water.

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“…Nakagaki's group used a micro-sampling/chemical analysis technique that revealed variations in the external-to-pulpal surface direction similar to the variations we found. Elevated concentrations of F in the exterior surface of normal root tissue have been reported previously [Yoon et al, 1960] and it is now known that this F is mainly in cementum, particularly the acellular cementum [Nakagaki et al, 1988], of- ten with an additional minor peak in dentine at the cementum-dentine junction [Nakagaki et al, 1987]. Our maximum F concentrations, ranging from 2,500 to 13,000 ppm, were higher than those reported by Takeuchi et al [1996], possibly because of the higher resolution of our method, but lower than those found by Dérand et al [1989] in artificial root lesions treated with topical F solutions.…”

Section: Discussionmentioning

confidence: 95%

Fluoride Distribution in Sound and Carious Root Tissues of Human Teeth

Shu

Pearce²,

Sissons³

et al. 1998

Caries Res

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Proton probe analysis has been used to provide for the first time quantitative F concentration data in carious root tissues from subjects consuming water containing 1 ppm F. In small lesions at the neck of the tooth with minimal tissue loss the F concentration was significantly higher at the outer lesion edge than at the outer edge of adjacent sound root tissue. In one sample with high F values the lesion edge had 19,000 ppm F and the adjacent sound root surface 5,400 ppm F (μg F/g apatite). In large lesions with extensive cavitation F was again concentrated in the outer edge of the lesion and was significantly higher (1,800–4,100 ppm) than in adjacent sound inner dentine (190–290 ppm). Fluoride concentrations varied markedly along the outer edge of both normal and carious root tissues. Fluoride increase at the lesion edge is not an effect of tissue shrinkage but probably a result of remineralisation events during caries. This additional F may be expected to increase tissue resistance to further acid attacks.

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Fluoride distribution and histological structure of human cementum

Cited by 26 publications

References 15 publications

Distribution of Fluoride across Cementum, Dentine and Alveolar Bone in Rats

Distribution of Fluoride across Cementum, Dentine and Alveolar Bone in Rats

Fluoride Distribution of Rat Molar Cementum in Relation to Age and Fluoride Levels in the Drinking Water

Fluoride Distribution in Sound and Carious Root Tissues of Human Teeth

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