Fluoride concentration and pH of pediatric medicines regulary and long-term used by children

Passos, Isabela Albuquerque; Freitas, Cláudia Helena Soares de Morais; Sampaio, Fábio Correia

doi:10.4317/medoral.16.e459

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Long-term use of medications is frequently associated only to the beneficial effects to children's general health, but it may have deleterious effects to the oral health if preventive measures are not incorporated after ingestion of liquid medications 24 . Considering the cariogenic and erosive potential of sweetened and acidic medications prescribed to children, it is important that health professionals, especially paediatricians and paediatric dentists, are engaged in educating parents to ensure adequate oral clearance after each dose of medication as a primary step for minimizing the risk of dental caries and erosion of dental structures related to long-term, and sometimes unsupervised, regimens with sugar-containing liquid oral medications 9 .…”

Section: Results Discussionmentioning

confidence: 99%

In vitro Evaluation of Different Physicochemical Properties of Pediatric Medicines

Cavalcanti¹,

VIEIRA²,

Souto³

et al. 2013

Pesq Bras Odontoped Clin Integr

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Objective: To evaluate in vitro the endogenous pH, the total titratable acidity (TTA) and o Brix of pediatric medicines. Method: The sample consisted of 22 pediatric medicines belonging to five classes: antibiotics, antihistamines, anthelmintics, non-steroid antiinflammatory drugs and corticoids. The pH was measured with a potentiometer, total acidity was obtained by the AOAC method and o Brix was determined by refractometry. The data were expressed as means and the differences among the groups were analyzed by ANOVA. The significance level was set at 0.05 with a 95% confidence level. Results: As much as 59.1% of the medicines presented pH lower than 5.5, being therefore potentially erosive to the dental tissues. Benflogin (1.75) and Predsim (7.35) presented the lowest and the highest pH means, respectively. As for TTA, the lowest mean was obtained for Cataflan (0.01%) and the highest for Infectrin (0.98%). Evaluation of o Brix revealed that Alersin presented the lowest mean (6.25%) and Cataflan (74.33%) presented the highest mean. There was no statistically significant difference among the medicine classes regarding the pH (p=0.950) or regarding the o Brix (p=0.477). On the other hand, there were statistically significant differences among the medicine classes for TTA (p=0.000); the greatest differences were found between the antibiotics and the anti-inflammatory drugs (p=0.002), the anthelmintics (p=0.003) and the corticoids (p=0.005). Conclusion:The pediatric medicines may be considered as potentially erosive to the dental tissues. In view of the statistically significant differences among the medicine classes regarding the TTA, it is recommended that the control and follow up be directed to the erosive potential of each class. The antibiotics are the class of medicine with the highest pH and acidity, and so its intake should be followed by an adequate oral hygiene. (74,33%). Não se verificou diferença estatisticamente significativa entre as variáveis pH e a classe de medicamento (P=0,950) e entre o °Brix e a classe de medicamento (P=0,477). Todavia, verificou-se diferenças estatisticamente significante em relação à acidez total e a classe de medicamento (P = 0,000), de modo que as diferenças maiores ficaram entre as médias dos antibióticos com: os antiinflamatórios (P=0,002), os antiparasitários (P=0,003) e os corticóides (P=0,005). Conclusão: Os medicamentos pediátricos analisados podem ser considerados potencialmente erosivos aos tecidos dentais. Em virtude das diferenças estatisticamente significativas entre as classes de medicamentos em relação à acidez total é necessário que o controle e o acompanhamento sejam direcionados ao potencial erosivo de cada classe, apontando os antibióticos como a classe com maiores médias de pH e acidez, devendo a sua administração ser controlada e acompanhada por uma adequada higiene oral. ABSTRACT RESUMO KEY-WORDS DESCRITORES 60Pesq Bras Odontoped Clin Integr, João Pessoa, 13(1):69-

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Section: Results Discussionmentioning

confidence: 99%

In vitro Evaluation of Different Physicochemical Properties of Pediatric Medicines

Cavalcanti¹,

VIEIRA²,

Souto³

et al. 2013

Pesq Bras Odontoped Clin Integr

View full text Add to dashboard Cite

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“…Thus, this should be the contributing factor why group 1 showed greater sized craters in SEM compared with other PLM. Studies done by Kiran et al, 6 Cavalcanti et al, 7 Passos et al, 8 and Babu et al 4 had assessed pH in their respective studies and concluded that PLMs with critically low pH had the ability to initiate dental demineralization and can cause surface erosion by acting directly on enamel surface. At critical pH, enamel gets unsaturated and sufficiently high concentrations of unionized acid ensure the inward diffusion of enough acid to extend the lesion.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of the Four most commonly used Pediatric Liquid Formulations in Ahmedabad City: An in vitro Study

Venkataraghavan¹

2017

World Journal of Dentistry

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“…Levando em consideração que os antibióticos pediátricos líquidos representam um fator de risco à cárie dentária, é necessária uma certa cautela na prescrição desses fármacos. Além disso, é essencial uma adequada orientação quanto ao momento oportuno de administração do medicamento e a manutenção de uma satisfatória higienização oral 31,32 .…”

Section: Fonte: Autoresunclassified

Identificação dos edulcorantes utilizados na composição de antibióticos de uso pediátrico

Lima Júnior,

Dias,

Ferreira

et al. 2023

Braz. J. Implantol. Health Sci.

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Na indústria farmacêutica pode-se encontrar uma gama de medicamentos líquidos os quais apresentam um sabor desagradável, fazendo-se necessário combinar diversos edulcorantes no mesmo produto para torná-lo com um sabor agradável, em especial quando se trata de pacientes pediátricos. O estudo apresenta como objetivo identificar o tipo de edulcorantes utilizados na fabricação dos antibióticos pediátricos. O trabalho é do tipo quantitativo e retrospectivo, realizado através da leitura ds informações apresentadas nas bulas de quatro medicamentos pediátricos selecionados. Além disso, realizou-se um levantamento nas bases de dados Scielo, Lilacs e PubMed; livros, teses de mestrado e doutorado. Constatou-se que os antibióticos pediátricos apresentam diversos tipos de excipientes em suas composições, em especial os edulcorantes, os quais apresentam uma relação direta com a condição de saúde bucal da criança. Dos quatro medicamentos analisados, todos apresentam algum tipo de edulcorante - principalmente a sacarose - com o intuito principal de melhorar seu sabor e aceitação dos pacientes.

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Fluoride concentration and pH of pediatric medicines regulary and long-term used by children

Cited by 9 publications

References 18 publications

In vitro Evaluation of Different Physicochemical Properties of Pediatric Medicines

In vitro Evaluation of Different Physicochemical Properties of Pediatric Medicines

Comparative Evaluation of the Four most commonly used Pediatric Liquid Formulations in Ahmedabad City: An in vitro Study

Identificação dos edulcorantes utilizados na composição de antibióticos de uso pediátrico

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