Fluorescent silk fibroin nanoparticles prepared using a reverse microemulsion

Myung, Seung Jun; Kim, Hun Sik; Kim, Ye Seul; Chen, Peng; Jin, Hyoung Joon

doi:10.1007/bf03218567

Cited by 46 publications

(25 citation statements)

References 24 publications

(22 reference statements)

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“…The factor was used to convert the diameters of individual particles to nm. A number of particles (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) were selected for each sample and the size distribution was determined.…”

Section: Particle Size Measurementmentioning

confidence: 99%

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Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Khalid

Mitropoulos

Marelli

et al. 2015

Biomed. Opt. Express

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Nanoparticle (NP) based technologies have proved to be considerably beneficial for advances in biomedicine especially in the areas of disease detection, drug delivery and bioimaging. Over the last few decades, NPs have garnered interest for their exemplary impacts on the detection, treatment, and prevention of cancer. The full potential of these technologies are yet to be employed for clinical use. The ongoing research and development in this field demands single multifunctional composite materials that can be employed simultaneously for drug delivery and biomedical imaging. In this manuscript, a unique combination of silk fibroin (SF) and nanodiamonds (NDs) in the form of nanospheres are fabricated and investigated. The spheres were loaded with the anthracyline Doxorubicin (DoX) and the drug release kinetics for these ND-SF-DoX (NDSX) spheres were studied. NDs provided the fluorescence modality for imaging while the degradable SF spheres stabilized and released the drug in a controlled manner. The emission and structural properties of the spheres were characterized during drug release. The degradability of SF and the subsequent release of DoX from the spheres were monitored through fluorescence of NDs inside the spheres. This research demonstrates the enormous potential of the ND-SF nanocomposite platforms for diagnostic and therapeutic purposes, which are both important for pharmaceutical research and clinical settings. "Nanodiamond-mediated drug delivery and imaging: challenges and opportunities," Expert Opin. Drug Deliv. 12(5), 735-749 (2015).

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Section: Particle Size Measurementmentioning

confidence: 99%

“…Moreover, the degradability of SF in biological environment can lead to significant uncertainty in the fluorophore emission. This uncertainty in the emission from the degraded SF makes it harder to determine whether it is the fluorescence from the SF structure where the drug is located or the dye that is being traced [27].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Khalid

Mitropoulos

Marelli

et al. 2015

Biomed. Opt. Express

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“…Upon dissolution of silk fibroin, additives can be simply added to the solution to produce functional silk. In addition to proteins, dyes were added into the silk fibroin solution to prepare dye‐doped silk fibroin in the forms of nanoparticles or thin films as biosensors 55, 56…”

Section: Extrinsically Colored/luminescent Silk Through Post‐procementioning

confidence: 99%

Functional Silk: Colored and Luminescent

2012

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Silkworm silk is among the most widely used natural fibers for textile and biomedical applications due to its extraordinary mechanical properties and superior biocompatibility. A number of physical and chemical processes have also been developed to reconstruct silk into various forms or to artificially produce silk-like materials. In addition to the direct use and the delicate replication of silk's natural structure and properties, there is a growing interest to introduce more new functionalities into silk while maintaining its advantageous intrinsic properties. In this review we assess various methods and their merits to produce functional silk, specifically those with color and luminescence, through post-processing steps as well as biological approaches. There is a highlight on intrinsically colored and luminescent silk produced directly from silkworms for a wide range of applications, and a discussion on the suitable molecular properties for being incorporated effectively into silk while it is being produced in the silk gland. With these understanding, a new generation of silk containing various functional materials (e.g., drugs, antibiotics and stimuli-sensitive dyes) would be produced for novel applications such as cancer therapy with controlled release feature, wound dressing with monitoring/sensing feature, tissue engineering scaffolds with antibacterial, anticoagulant or anti-inflammatory feature, and many others.

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“…16,17 Furthermore, cellulose backbone can be grafted onto synthetic polymers to control elasticity, ion exchangeability, thermal stability, and mechanical properties, via 'grafting-from' or 'grafting-onto' way through various polymerization techniques. [18][19][20][21] Several papers have described useful cellulose ether grafting with uniform grafts using various methods. 22 In this study, HPMC resin-fortified poly(EA-co-MMA) particles [HPMC-g-poly(EA-co-MMA) NPs] were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN) as a redox initiator in the presence of HPMC.…”

Section: Introductionmentioning

confidence: 99%

Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization

et al. 2010

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This article describes the preparation and characterization of hydroxypropyl methylcellulose-graftpoly(ethylacrylate-co-methyl methacrylate) particles [HPMC-g-poly(EA-co-MMA) NPs]. The particles were prepared by resin-fortified emulsion polymerization using ceric ammonium nitrate (CAN). In this study, a series of HPMC-g-poly(EA-co-MMA) NPs were synthesized by varying the CAN : HPMC and HPMC : (EA/MMA) ratios to determine the effects of these variables on the physical properties of HPMC-g-poly(EA-co-MMA) as well as the dissolution behavior of an aspirin tablet, as a model drug. The drug dissolution profiles of the coated tablets were affected significantly by the HPMC : (EA/MMA) molar ratio.

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Fluorescent silk fibroin nanoparticles prepared using a reverse microemulsion

Cited by 46 publications

References 24 publications

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Functional Silk: Colored and Luminescent

Hydroxypropyl methylcellulose-graft-poly(ethyl acrylate-co-methyl methacrylate) particles by resin-fortified emulsion polymerization

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