Fluorescent silk cocoon creating fluorescent diatom using a “Water glass-fluorophore ferry”

Kusurkar, Tejas Sanjeev; Tandon, Ishita; Sethy, Niroj Kumar; Bhargava, Kalpana; Sarkar, Sabyasachi; Singh, Sushil Kumar; Das, Mainak

doi:10.1038/srep03290

Cited by 28 publications

(28 citation statements)

References 28 publications

(59 reference statements)

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“…Fluorescent silk, one of the novel natural functional biomaterials, is gaining enormous attention due to its great potential for biomedical and intelligent textile-related applications [1][2][3][4][5]. It has been reported that fluorescence can be imparted through the incorporation of various organic dyes and inorganic nanoparticles into silk through post-dyeing of naturally produced silk [6,7].…”

Section: Introductionmentioning

confidence: 99%

Super-strong and Intrinsically Fluorescent Silkworm Silk from Carbon Nanodots Feeding

et al. 2019

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HIGHLIGHTS • Intrinsically, super-strong fluorescent silk was fabricated via feeding Bombyx mori silkworms with carbon nanodots. • The multi-functional silks showed no cytotoxicity to Schwann cells and exhibited great potential in bioimaging. • The reinforcing mechanism of multi-functional silks was proposed. ABSTRACT Fluorescent silk is fundamentally important for the development of future tissue engineering scaffolds. Despite great progress in the preparation of a variety of colored silks, fluorescent silk with enhanced mechanical properties has yet to be explored. In this study, we report on the fabrication of intrinsically super-strong fluorescent silk by feeding Bombyx mori silkworm carbon nanodots (CNDs). The CNDs were incorporated into silk fibroin, hindering the conformation transformation, confining crystallization, and inducing orientation of mesophase. The resultant silk exhibited super-strong mechanical properties with breaking strength of 521.9 ± 82.7 MPa and breaking elongation of 19.2 ± 4.3%, improvements of 55.1% and 53.6%, respectively, in comparison with regular silk. The CNDs-reinforced silk displayed intrinsic blue fluorescence when exposed to 405 nm laser and exhibited no cytotoxic effect on cells, suggesting that multi-functional silks would be potentially useful in bioimaging and other applications.

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Section: Introductionmentioning

confidence: 99%

Super-strong and Intrinsically Fluorescent Silkworm Silk from Carbon Nanodots Feeding

et al. 2019

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“…White SF produced due to the removal of sericin by a degumming process. However, there is considerable confirmation presenting that silk cocoons have a fluorescent nature, generally due to the existence of flavonoids, including quercetin derivatives (Tamura et al, 2002;Daimon et al, 2010;Kusurkar et al, 2013) and carotenoid compounds (Harizuka, 1953). It has been evident that like silk cocoons, SF-derived scaffolds exhibit a fluorescence index in UV, green, and blue, lights (Mandal and Kundu, 2009;Zhang et al, 2010;Kundu et al, 2012;Hodgkinson et al, 2014;Bhardwaj et al, 2015).…”

Section: Preparation Methods Of Fluorescent Silk Materials Natural (Amentioning

confidence: 99%

Recent Advances in Fluorescent Silk Fibroin

et al. 2020

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Silk is a natural macromolecular protein consisting of fibroin and sericin. Silk fibroin (SF), derived from Bombyx mori, is a representative fibrous protein that has been used mainly in fashion textiles and surgical sutures. Also, SF has been extensively applied as a potential biomaterial in a number of biomedical and biotechnological fields, as SF can be reconstituted in various forms through physical and chemical processes. In addition to direct use of SF with intrinsic structure and properties, there are many researchers attempt to insert more novel functional properties into SF, despite retaining its favorable natural characteristics. In recent years, fluorescent silk obtained through various methods, such as the genetic modification or dye feeding method, has been applied in a variety of medical fields. These functionalized silks have properties that can be applied to new and versatile fields more than currently existing fields such as drug delivery, monitoring surgical and wound healing processes. This review focuses on the preparation methods and the latest technological advances on the use of fluorescent SF materials, especially their biomedical applications.

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“…Some additional properties like fluorescence can be incorporated into the fibers by feeding silk larvae with the plant quercetin, which becomes exported to the cocoon [61] . Silk proteins can be dissolved into solution to produce various SBBs including regenerated fibers, fibrous mats and scaffolds using wet/electro spinning or hand-drawing process.…”

Section: Sources Processing and Regeneration Of Silk For Biomedicmentioning

confidence: 99%

Silk‐Based Biomaterials in Biomedical Textiles and Fiber‐Based Implants

Chen

et al. 2015

Adv Healthcare Materials

144

103

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Biomedical textiles and fiber-based implants (BTFIs) have been in routine clinical use to facilitate healing for nearly five decades. Amongst the variety of biomaterials used, silk-based biomaterials (SBBs) have been widely used clinically viz. sutures for centuries and are being increasingly recognized as a prospective material for biomedical textiles. The ease of processing, controllable degradability, remarkable mechanical properties and biocompatibility have prompted the use of SBBs for various BTFIs for extracorporeal implants, soft tissue repair, healthcare/hygiene products and related needs. The present review focuses on BTFIs from the perspective of types and physical and biological properties, and this discussion is followed with an examination of the advantages and limitations of BTFIs from SBBs. The review covers progress in surface coatings, physical and chemical modifications of SBBs for BTFIs and identifies future needs and opportunities for the further development for BTFIs using SBBs.

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Fluorescent silk cocoon creating fluorescent diatom using a “Water glass-fluorophore ferry”

Cited by 28 publications

References 28 publications

Super-strong and Intrinsically Fluorescent Silkworm Silk from Carbon Nanodots Feeding

Super-strong and Intrinsically Fluorescent Silkworm Silk from Carbon Nanodots Feeding

Recent Advances in Fluorescent Silk Fibroin

Silk‐Based Biomaterials in Biomedical Textiles and Fiber‐Based Implants

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