Fluorescent probes in public health and public safety

General Method for Pesticide Recognition Using Albumin-Based Host–Guest Ensembles

“…The six fluorescent dyes (DNSA, FLAV, CHAL, HMM, NEFLA, and HCEM) were prepared, and their chemical structures were confirmed by 1 H NMR, 13 C NMR, and HRMS (see the Synthesis Section and Figures S1−S9 in the Supporting Information). The first four dyes were synthesized according to previous studies, 46−49 and the latter two were newly designed for this study.…”

“…Fluorimetry is a powerful analytical method by virtue of its low cost, high sensitivity, and synthetic tailorability for the sensors to achieve the desired specificity. , It also offers significant advantages of good portability and on-site measurement simply with the aid of a smartphone, even by the naked eyes if the sensor gives the signal in the visible light region . To date, a large number of fluorescent sensors for pesticide detection have been reported, − and most of them can fall into two major categories (Figure a). For the enzyme assay, the pesticide serves as the substrate (or inhibitor) to initiate/inhibit an enzymatic reaction, which triggers the fluorescence change of the sensor .…”

Activity-Based Approach for Selective Molecular CO2 Sensing

“…31 The high selectivity and sensitivity of this approach have led to considerable advances in our understanding of the role played by small molecules in numerous research areas. 28,32,33 In light of the relevance of CO 2 and the power of ABS approaches to sense small molecules, the development of highly selective and sensitive CO 2 activity-based sensors would unlock numerous multidisciplinary applications. Notably, alternative molecular approaches to sense CO 2 have been limited to nonselective chemical reactions, such as the reversible attack of amines or N-heterocyclic carbenes onto CO 2 forming carbamates or carboxylates, 26,34,35 thus severely limiting the selectivity and sensitivity of those sensing processes, and, ultimately, their utility.…”

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

“…Fortunately, fluorescence imaging has emerged as a robust technique for the direct visualization of molecular events due to its outstanding sensitivity, high temporal-spatial resolution and noninvasive nature. [25][26][27][28][29][30][31][32][33][34][35] In particular, small-molecule fluorescent probes exhibit some unique merits, including facile synthesis and modification, excellent penetration and targeting ability and satisfactory reproducibility. [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] Consequently, numerous small-molecule fluorescent probes have been explosively fabricated to explore ER as well as its corresponding active species in recent years.…”