Fluorescent probes for targeting endoplasmic reticulum: design strategies and their applications

Singh, Deepmala; Rajput, Deeksha; Kanvah, Sriram

doi:10.1039/d1cc06944f

Cited by 52 publications

(30 citation statements)

References 98 publications

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“…18,19 The literature reveals many examples, majorly based on a naphthalimide scaffold bearing a sulfonamide functional moiety. [23][24][25] Despite the known fluorophores that target the endoplasmic reticulum, newer fluorophores capable of imaging the ER while simultaneously allowing study of the dynamics and intracellular processes, such as the determination of viscosity, micropolarity, and inter-organelle interactions, are needed. The structures with a donor-π-acceptor (D-π-A) scaffold offer flexibility in the structural design to probe such intracellular processes.…”

Section: Introductionmentioning

confidence: 99%

Lutidine derivatives for live-cell imaging of the mitochondria and endoplasmic reticulum

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Lutidine derivatives for live-cell imaging of the mitochondria and endoplasmic reticulum

et al. 2022

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“…The ER surface proteins that contain the sulfydryl group may react with the pentafluorophenyl group through a halogen-substituted reaction. Moreover, resorufin ( 32 , Scheme 4 ), Pennsylvania green ( 33 , Scheme 4 ), and other groups are also used to design ER-targeting probes [ 120 ]. Recently reported hydrophobic resorufamine derivatives, which possess a structural similarity to fluorinated hydrophobic rhodol fluorophores, may accumulate in the ER of mammalian cells and were developed to target the ER [ 121 ].…”

Section: Design Of Molecular Probes For Organelle-targeted Cell Imagingmentioning

confidence: 99%

Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging

Dai

Cui

et al. 2023

Biosensors

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Fluorescent molecular probes are very powerful tools that have been generally applied in cell imaging in the research fields of biology, pathology, pharmacology, biochemistry, and medical science. In the last couple of decades, numerous molecular probes endowed with high specificity to particular organelles have been designed to illustrate intracellular images in more detail at the subcellular level. Nowadays, the development of cell biology has enabled the investigation process to go deeply into cells, even at the molecular level. Therefore, probes that can sketch a particular organelle’s location while responding to certain parameters to evaluate intracellular bioprocesses are under urgent demand. It is significant to understand the basic ideas of organelle properties, as well as the vital substances related to each unique organelle, for the design of probes with high specificity and efficiency. In this review, we summarize representative multifunctional fluorescent molecular probes developed in the last decade. We focus on probes that can specially target nuclei, mitochondria, endoplasmic reticulums, and lysosomes. In each section, we first briefly introduce the significance and properties of different organelles. We then discuss how probes are designed to make them highly organelle-specific. Finally, we also consider how probes are constructed to endow them with additional functions to recognize particular physical/chemical signals of targeted organelles. Moreover, a perspective on the challenges in future applications of highly specific molecular probes in cell imaging is also proposed. We hope that this review can provide researchers with additional conceptual information about developing probes for cell imaging, assisting scientists interested in molecular biology, cell biology, and biochemistry to accelerate their scientific studies.

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“…[11][12][13] The photo-physical properties of naphthalimide derivatives are routinely utilized in analytical chemistry. [14][15][16][17][18][19][20][21][22] Naphthalimide derivatives show aggregation induced emission (AIE), and are useful AIEgens for biological studies. 23 Naphthalimide based compounds bind to DNA, 24,25 and this aspect has been extended to photo-dynamic therapies for treatment of diseases like cancer.…”

Section: Introductionmentioning

confidence: 99%

Polymorphs, ionic cocrystal and inclusion complex of N-amino-1,8-naphthalimide

Baruah

Sendh

2023

CrystEngComm

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Fluorescent probes for targeting endoplasmic reticulum: design strategies and their applications

Abstract: Advances in developing organic fluorescent probes and fluorescence imaging techniques have enhanced our understanding of cell biology. The endoplasmic reticulum (ER) is a dynamic structure that plays a crucial role...

Cited by 52 publications

References 98 publications

Lutidine derivatives for live-cell imaging of the mitochondria and endoplasmic reticulum

Lutidine derivatives for live-cell imaging of the mitochondria and endoplasmic reticulum

Recent Development of Advanced Fluorescent Molecular Probes for Organelle-Targeted Cell Imaging

Polymorphs, ionic cocrystal and inclusion complex of N-amino-1,8-naphthalimide

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