Fluorescent pH‐Responsive Mesoporous Silica Nanoparticles with Core‐Shell Feature as a Traceable Delivery Carrier for Ibuprofen

Abstract

The fluorescent pH-responsive mesoporous silica nanoparticles (P@BMMs) were prepared, in which, the (2-[3-(triethoxysilyl) propyl]-1H-Benz [de]isoquinoline-1, 3(2H)-dione) -poly(acrylic acid) (PID-PAA) shell was covalently anchored onto the vinylmodified surface of the bimodal mesoporous materials (BMMs) core via one-step or two-step process. Their structural features were analyzed by XRD, SEM, TEM, TG, and SAXS, and the results showed that P@BMMs possessed typical fractal features from structural irregularity to surface roughness. Ibuprofen as a model drug was loaded into the mesopore channels of BMMs cores, particularly, the drug-releasing performances from P@BMMs carriers were pH-dependent. Meanwhile, the photoluminescent emission spectra and the fluorescent decay profiles presented that the hybrid P@BMMs with strong fluorescent intensity at 395 nm and 450 nm and longer decay lifetimes (such as 3.53 and 18.86 ns for P@BMMs-I-10) is a promising drug carrier, which can be used in potential applications for controlled drug delivery.[a] T.

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

“…Meanwhile, using vinyl-modified bimodal mesopores SiO 2 (abbreviated as BMMs) as a core and pH-sensitive fluorescent polymers as a shell, pH-responsive fluorescent hybrid nanoparticles (P@BMMs) with core-shell structures were successfully prepared. The results revealed that the fluorescence intensity of the resultant P@BMMs nanoparticles could achieve a good fluorescence labeling effect for potential application in tracing drug sustained/controlled delivery fields [ 16 ]. However, the fluorescent performances are uncertain in the drug delivery process due to unclear understanding of the dispersion behaviors and agglomeration properties of organic fluorescent molecules in the drug carrier.…”

Dispersion Performances of Naphthalimides Doped in Dual Temperature- and pH-Sensitive Poly (N-Isopropylacrylamide-co-acrylic Acid) Shell Assembled with Vinyl-Modified Mesoporous SiO2 Core for Fluorescence Cell Imaging

“…In our preliminary work [ 25 , 26 , 27 ], a series of luminescent hybrid nanoparticles with effectively luminescent performances was prepared using BMMs as a carrier and NA derivatives as luminescent probes through surface modification, presenting a longer fluorescent lifetime (2.2–3.4 ns) that was caused by the delocalized pair of electrons in the electron-withdrawing conjugate structures. Thereafter, Liu et al and Wei et al [ 28 , 29 ] further developed a series of core–shell structured nanocomposites with strong fluorescent features and dual temperature- and pH-responsive properties through self-assembly technology, in which the BMM was used as a core and the fluorescent molecule PID-dispersed P(NIPAM-co-AA) acted as a shell. Notably, the resultant hybrid nanocomposite PID/P@BMMs with two lifetimes of 2.53 and 18.86 ns not only possessed an excellent controlled IBU release of 71.1% at 37 °C and 82.7% at pH 2.0 but also presented a stable fluorescence intensity at the 395–450 nm wavelength during drug loading and releasing.…”