Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms

Abstract

Fluorescence imaging is a powerful approach for noninvasive and real-time visualization and tracking of biomolecules and biological processes in living systems. The fluorescent chemosensors with dual/triple interplaying sensing mechanisms tend to provide diverse fluorescence signals or amplify the response signals, which are propitious to simultaneously track multiple analytes or to improve the selectivity and sensitivity of the chemosensors. Thus, the development of dual/triple sensing mechanism-based chemosensors has attracted great interest recently. This review highlights the representative cases of the fluorescent chemosensors with dual/triple interplaying sensing mechanisms published since 2010, and these chemosensors are classified according to the types of the interplaying sensing mechanisms, including ICT-FRET, PET-FRET, PET-ICT-ESIPT, etc.

A Fluorescent and Colorimetric Chemosensor for Hg2+ Based on Rhodamine 6G With a Two-Step Reaction Mechanism

“…Compared to other common methods for Hg 2+ detection, fluorescent chemosensors have received considerable attention because of their distinct advantages (Nolna and Lippard, 2008;Zhang et al, 2008;Lee et al, 2015;Xie et al, 2015;He et al, 2016;Sakunkaewkasem et al, 2018;Bai et al, 2019;Yuan et al, 2019). As a result, a growing number of fluorescent chemosensors for Hg 2+ have been reported in the past few decades (Chen et al, 2011;Wang et al, 2012;Park et al, 2013;Cheng et al, 2015;Hong et al, 2016;Lee et al, 2016;Erdemir et al, 2017;Bai et al, 2018;Singh et al, 2018).…”

A Light‐Up Fluorescent Probe for Detection of Formaldehyde in Serum and Gaseous Based on d‐PeT Process

“…Recently, fluorescent probes have become an important molecular tools for monitoring active molecules or toxic compounds in various environmental systems with high spatial and temporal resolution. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] To date, A series of aza-cope reaction-based fluorescent probes for sensing formaldehyde in environmental and biological systems have been designed and synthesized. [24][25][26][27][28][29][30][31][32][33] However, most of these probes still have many disadvantages such as poor water solubility, longer response time, lower sensitivity, etc.…”

Hypochlorite‐Mediated Modulation of Photoinduced Electron Transfer in a Phenothiazine–Boron dipyrromethene Electron Donor–Acceptor Dyad: A Highly Water Soluble “Turn‐On” Fluorescent Probe for Hypochlorite

“…The sensing mechanismsi nt hese probesi ncluded internal charge transfer (ICT), Fçrster resonance energy transfer (FRET)a nd through-bond energy transfer (TBET), photoinducede lectron transfer (PET), excited-state intramolecular protont ransfer (ESIPT) chelation-induced fluorescencee nhancement (CHEF), and aggregation-induced enhancement( AIE). [8] Fluorescence sensing has greater advantages over colorimetric methodsd ue to highers ensitivity,h igh temporal and spatial resolution, and applicability not only for in vitro assays buta lso for in vivo imaging studies with readily available instruments. Fluorescent probesh ave become promising tools in clinical medicine and biomedical research because they deliverd ynamic information on the localization and quantification of biological molecules of interestinl iving cells and tissues.…”