A Light‐Up Fluorescent Probe for Detection of Formaldehyde in Serum and Gaseous Based on d‐PeT Process

Abstract

A new Light‐Up fluorescent probe (FA‐P) for detection of formaldehyde was designed and synthesized based on the donor‐excited photo induced electron transfer (d‐PeT) process. The probe FA‐P was constructed by integrating a benzothiazole derivatives as the fluorescent skeleton and homoallylamino group as the specific recognition site. It showed the unique advantages of easy‐preparation, and excellent selectivity response toward formaldehyde. Besides, The probe FA‐P can not only detect formaldehyde gas through the prepared test paper, but also detect formaldehyde in serum solution.

Reaction-based fluorescent and chemiluminescent probes for formaldehyde detection and imaging

“…6). [50][51][52][53][54][55][56][57][58] These probes have been used to detect FA with high sensitivity and selectivity in various samples, such as air, aqueous sample, serum, real food and living cells.…”

“…Soon afterwards, further development of organelle-targeting probes to FA have been reported based on the structure provided by Lin's group. These probes can be targeted to the endoplasmic reticulum (58,59), mitochondria (60,61), and lysosomes (62) specifically and used to monitor exogenous and endogenous FA in living cells. [82][83][84][85][86] Among them, probe 59 exhibited a penetration depth of up to about 80 mm in sensing FA in liver tissue slices of living mice.…”

Activity‐Based Fluorescent Probes for Sensing and Imaging of Reactive Carbonyl Species (RCSs)

“…developed FA−P for the detection of FA. A turn‐on detection mechanism with a LOD 2.5×10 −4 M made the probe applicable towards gaseous FA detection [76] …”

Optical chemosensors for the gas phase detection of aldehydes: mechanism, material design, and application

“…Compared to naked-eye-visual colorimetric methods, fluorometric chemosensors exhibit relatively rapid response and high sensitivity for detection of trace gaseous analytes under UV light irradiation. 34,60,96,97 According to fluorometric chemosensors for detecting aldehydes, this paper divided the reaction mechanism into four categories, including aldimine condensation, [98][99][100][101][102][103][104][105] Aza-Cope rearrangement, [106][107][108][109] QDs adjustment, 110,111 and functional MOFs interaction. 112,113 Most of these reactive fluorescent probes have been applied to detect aldehydes through the chemical reaction between -CHO group and the amine group on the probe.…”

“…However, for gaseous FA detection, a fluorescence changes from blue to yellow within 1 h was verified by the only one substrate (filter paper strip) and no data of LDL was reported. Subsequently, they 107 modified HBT with 4nitrobenzyl (Ph-NO 2 ) possessing strong electron donor effect to synthesize a more sensitive probe (FA-P) for FA detection (Fig. 20c).…”