Fluorescent Carbon Dots for Bioimaging and Biosensing Applications

Comparative performance evaluation of carbon dot-based paper immunoassay on Whatman filter paper and nitrocellulose paper in the detection of HIV infection

“…Thus, we need a fluorophore which overcomes problems described above while combining the advantages they offer. Carbon quantum dots present an attractive option in this regard and are gaining increasing application in biosensing and bioimaging because they display excellent stable photoluminescence, high resistance to photobleaching and low toxicity (Lim et al 2015;Li et al 2012;Shi et al 2014). Moreover, their synthesis is relatively simple, inexpensive and non-toxic (Peng and Travas-Sejdic 2009;Derfus et al 2004;Chunduri et al 2016).…”

Synergetic Effects of Combined Nanomaterials for Biosensing Applications

“…Their nanostructured part in the form of carbon nanotubes [76], fullerenes [77], or graphene [78] partly became the material of choice for improved performances of bioanalytical devices [79]. More recently, fluorescent carbon nanodots have attracted attention as non-toxic alternatives to quantum dots for optical biosensing and bioimaging [80]. Efficient functionalization techniques were established for carbon nanomaterials which allow the formation of bioassemblies and to combine the beneficial properties with those of other nanosized materials [81].…”

“…Even when great progress was achieved in the synthesis and isolation of carbon QDs with specific properties, the controlled synthesis of defined domain distribution and surface functionalities leading to distinguished absorption and emission spectra, as it is the case for semiconductor QDs, remains a challenge [140,141]. In terms of biosensing applications, carbon QDs show similar performances as semiconductor QDs concerning FRET-based biosensing and as fluorescence labels [80]. Efficient FRET between gold nanoparticles and carbon QDs could be achieved when each nano-object is modified with a corresponding antibody-antigen system [142].…”

Recent Developments in Active Tumor Targeted Multifunctional Nanoparticles for Combination Chemotherapy in Cancer Treatment and Imaging

“…33 Presently, radionuclide labeling is the only technique that can be used to provide in situ quantitative information-, but radio emitters may be too unstable to conjugate with nano-materials. 33 With the help of recently developed in vivo imaging probes like magnetic nanoparticles, 34, 35 quantum dots, 36, 37 gold nanoparticles, 38, 39 and carbon nanotubes, 40, 41 more imaging modalities may become available to track the distribution of nano-therapeutics in the body.…”