Synergetic Effects of Combined Nanomaterials for Biosensing Applications

Holzinger, Michael; Goff, Alan Le; Cosnier, Serge

doi:10.3390/s17051010

Cited by 51 publications

(17 citation statements)

References 151 publications

(154 reference statements)

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“…Carbon nanomaterials increase biocompatibility of the carbon surface towards the antibodies and protein avoiding denaturation and loss of their binding activity during the adsorption process. Also, CNTs and graphene increase electron transfer rates of carbon electrode surfaces, the major concern that carbon sensor platforms have [109,110,111,112,113].…”

Section: Strategies To Suppress Non-specific Binding Of Antibodiesmentioning

confidence: 99%

Suppressing Non-Specific Binding of Proteins onto Electrode Surfaces in the Development of Electrochemical Immunosensors

Contreras-Naranjo

Aguilar

2019

Biosensors

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Electrochemical immunosensors, EIs, are systems that combine the analytical power of electrochemical techniques and the high selectivity and specificity of antibodies in a solid phase immunoassay for target analyte. In EIs, the most used transducer platforms are screen printed electrodes, SPEs. Some characteristics of EIs are their low cost, portability for point of care testing (POCT) applications, high specificity and selectivity to the target molecule, low sample and reagent consumption and easy to use. Despite all these attractive features, still exist one to cover and it is the enhancement of the sensitivity of the EIs. In this review, an approach to understand how this can be achieved is presented. First, it is necessary to comprise thoroughly all the complex phenomena that happen simultaneously in the protein-surface interface when adsorption of the protein occurs. Physicochemical properties of the protein and the surface as well as the adsorption phenomena influence the sensitivity of the EIs. From this point, some strategies to suppress non-specific binding, NSB, of proteins onto electrode surfaces in order to improve the sensitivity of EIs are mentioned.

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Section: Strategies To Suppress Non-specific Binding Of Antibodiesmentioning

confidence: 99%

Suppressing Non-Specific Binding of Proteins onto Electrode Surfaces in the Development of Electrochemical Immunosensors

Contreras-Naranjo

Aguilar

2019

Biosensors

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“…In recent years, researchers have dedicated efforts to harnessing the unique atomic and molecular properties of nanobioengineered nanomaterials, including carbon nanomaterials, semiconductor/conductor polymers, metallic nanoparticles, and their nanoconjugates [10][11][12]. Such nanobiostructures may improve the interaction with the bioreceptors, thus dramatically amplifying the resultant signal, lowering the LOD, extending the linear detection range, shortening the testing time, and increasing the long-term stability of the detection systems [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

Soto

Orozco

2022

Molecules

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Nanoengineering biosensors have become more precise and sophisticated, raising the demand for highly sensitive architectures to monitor target analytes at extremely low concentrations often required, for example, for biomedical applications. We review recent advances in functional nanomaterials, mainly based on novel organic-inorganic hybrids with enhanced electro-physicochemical properties toward fulfilling this need. In this context, this review classifies some recently engineered organic-inorganic metallic-, silicon-, carbonaceous-, and polymeric-nanomaterials and describes their structural properties and features when incorporated into biosensing systems. It further shows the latest advances in ultrasensitive electrochemical biosensors engineered from such innovative nanomaterials highlighting their advantages concerning the concomitant constituents acting alone, fulfilling the gap from other reviews in the literature. Finally, it mentioned the limitations and opportunities of hybrid nanomaterials from the point of view of current nanotechnology and future considerations for advancing their use in enhanced electrochemical platforms.

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“…Metal nanoparticles (MNPs) have been employed in many recent and modern applications due to its enthralling potential including photovoltaic [ 1 , 2 ], sensing [ 3 ], catalysis [ 4 ], surface-enhanced Raman scattering [ 5 ] and biomedical [ 6 ]. https://www.synonyms.com/synonym/hitherto Numerous approaches reported in preparing MNPs either top-down (known as physical approach) or bottom-up approach, which referred to chemical approach.…”

Section: Introductionmentioning

confidence: 99%

The role of positively charge poly-L-lysine in the formation of high yield gold nanoplates on the surface for plasmonic sensing application

et al. 2021

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An anisotropic structure, gold (Au) nanoplates was synthesized using a two-step wet chemical seed mediated growth method (SMGM) directly on the substrate surface. Prior to the synthesis process, poly-l-lysine (PLL) as a cation polymer was used to enhance the yield of grown Au nanoplates. The electrostatic interaction of positive charged by PLL with negative charges from citrate-capped gold nanoseeds contributes to the yield increment. The percentage of PLL was varied from 0% to 10% to study the morphology of Au nanoplates in term of shape, size and surface density. 5% PLL with single layer treatment produce a variety of plate shapes such as hexagonal, flat rod and triangular obtained over the whole substrate surface with the estimated maximum yield up to ca. 48%. The high yield of Au nanoplates exhibit dual plasmonic peaks response that are associated with transverse and longitudinal localized surface plasmon resonance (TSPR and LSPR). Then, the PLL treatment process was repeated twice resulting the increment of Au nanoplates products to ca. 60%. The thin film Au nanoplates was further used as sensing materials in plasmonic sensor for detection of boric acid. The anisotropic Au nanoplates have four sensing parameters being monitored when the medium changes, which are peak position (wavelength shift), intensity of TSPR and LSPR, and the changes on sensing responses. The sensor responses are based on the interaction of light with dielectric properties from surrounding medium. The resonance effect produces by a collection of electron vibration on the Au nanoparticles surface after hit by light are captured as the responses. As a conclusion, it was found that the PLL treatment is capable to promote high yield of Au nanoplates. Moreover, the high yield of the Au nanoplates is an indication as excellent candidate for sensing material in plasmonic sensor.

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Synergetic Effects of Combined Nanomaterials for Biosensing Applications

Cited by 51 publications

References 151 publications

Suppressing Non-Specific Binding of Proteins onto Electrode Surfaces in the Development of Electrochemical Immunosensors

Suppressing Non-Specific Binding of Proteins onto Electrode Surfaces in the Development of Electrochemical Immunosensors

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

The role of positively charge poly-L-lysine in the formation of high yield gold nanoplates on the surface for plasmonic sensing application

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