Fluorescent black phosphorus quantum dots as label-free sensing probes for evaluation of acetylcholinesterase activity

Gu, Wei; Yan, Yinghan; Pei, Xueyu; Zhang, Cuiling; Ding, Caiping

doi:10.1016/j.snb.2017.05.017

Cited by 86 publications

(43 citation statements)

References 52 publications

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“…Based on the internal filtering effect (IFE) between BPQD and 2‐nitro‐5‐thiobenzoic acid anion (TNB), a fast, sensitive, and unlabeled fluorescent sensor platform was developed to evaluate the activity of AChE (Figure C). 5,5′‐Dithiobis‐(2‐nitrobenzoic acid) (DTNB) can react with thiol groups to generate TNB.…”

Section: Biomedical Applications Of Bpmentioning

confidence: 76%

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2D Black Phosphorus–Based Biomedical Applications

Luo

Fan

Zhou

et al. 2019

Adv Funct Materials

462

306

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Black phosphorus (BP) has increasingly attracted scientific attention since its first applications in biomedicine due to its unique properties and excellent biocompatibility. In particular, its layer-dependent bandgap, moderate carrier mobility, large surface-area-to-volume ratio, biodegradability, intrinsic photoacoustic properties, and biocompatibility make it an ideal candidate for use in photothermal therapy, photodynamic therapy, drug delivery, 3D printing, bioimaging, biosensing, and theranostics, which are reviewed here. In addition, the article discusses strategies to overcome challenges related to surface instability due to chemical degradation, a major obstacle for its application. This review not only provides a comprehensive summary on BP preparation and biomedical applications but also summarizes recent research and future possibilities.

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Section: Biomedical Applications Of Bpmentioning

confidence: 76%

Section: Biomedical Applications Of Bpmentioning

confidence: 99%

2D Black Phosphorus–Based Biomedical Applications

Luo

Fan

Zhou

et al. 2019

Adv Funct Materials

462

306

View full text Add to dashboard Cite

show abstract

“…The introduction of nanomaterials have contributed mostly to the diversity of FL biosensors and various structures of nanomaterials, to some extent, can be designed to rationalize the express of FL signal such as FL enhancement or FL quenching . BP nanomaterials, as one of the most popular nanomaterials, have also stimulated researchers to investigate their application in FL biosensing platform …”

Section: Biosensing Application Of Nano‐bpmentioning

confidence: 99%

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

Xia

Guo

2019

Adv Funct Materials

182

115

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Black phosphorus nanostructures (nano-BPs) include BP nanosheets, BP quantum dots, and BP nanoparticles. Since first being discovered in 2014, nano-BP has become one of the most popular nanomaterials. Nano-BP has many unique properties, such as excellent surface activity, tunable bandgap, high carrier mobility, moderate on/off ratio, excellent biocompatibility, good biodegradation, etc., all of which make nano-BP particularly attractive in biomedicine and biosensing. This review article comprehensively summarizes recent advances in synthesis, functionalization, biomedicine, and biosensing applications of nano-BP. Different methods are first introduced, such as mechanical cleavage, liquid-phase ultrasonic exfoliation, electrochemical exfoliation, solvothermal treatment, and acoustic-microfluidic stripping, for making the nano-BP. Then two strategies are emphasized to enhance ambient stability of nano-BP, namely physical encapsulation and chemical modification. Next, how to develop nano-BP as advanced imaging agents, nanocarriers, and nanomedicine for bioimaging (fluorescence imaging, thermal imaging, and photoacoustic imaging) and disease treatment (phototherapy and photo/chemical/immune synergistic therapy) is demonstrated. The biosensing applications on nano-BP is introduced, including electrochemical biosensor, fluorescence biosensor, chemiluminescence biosensor, electrogenerated chemiluminescence biosensor, and colorimetric biosensor. Finally, the current challenges and future perspectives on nano-BP in bioapplications are discussed. Nano-BP SynthesisLayered nanomaterials are usually exfoliated from bulk crystals. [35] Compared with bulk materials, monolayer or fewlayer nanomaterials possess the enhanced surface area, excellent physiochemical activity and optoelectronic property. The exfoliation from bulk crystal to monolayer or few-layer nanosheets has been widely applied for preparing almost all the 2D nanomaterials, graphene, MoS 2 , MXene nanosheets, etc. [36] Bulk BP, similar to graphite, is the stacking of layered BP nanosheets via the weak van der Waals force. The destruction of the external driving forces to the weak van der Waals interaction between the stack layers greatly contributes to the exfoliation of nano-BP from the bulk counterparts. Mechanical exfoliation and liquid phase ultrasonic exfoliation are the two most popular approaches, and some other methods were also involved, electrochemical exfoliation and solvothermal treatment, for instance. Table 1 summarizes the advantages and limitations of different exfoliation methods. Mechanical ExfoliationMechanical exfoliation, also called scotch-tape delamination, mainly utilizes the larger binding energy between the substrate and layered materials than van der Waals forces in Figure 2. a) Schematic illustration of meta-assisted mechanical exfoliation for FLBP. b) The left is FLBPs exfoliated using the normal scotch-tape microcleavage, and the right is FLBP exfoliated using Au-assisted method, and c) the total area of FLBP on 10 different samples. ...

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“…So far, BP has been used as photothermal agents, photodetectors, photocatalysts, organic photovoltaics, electrocatalysts, and the storage media 19–24. BP has also been studied in the field of sensors, such as humidity sensors,25 ratiometric fluorescent probes developed by the surface modification of organic molecules,26,27 field effect transistor detection of metal ions 28. In addition, BP has a wide range of applications in the biological field, including the medicine, drug carriers, and cancer treatment 29–31.…”

Section: Introductionmentioning

confidence: 99%

A Fluorescence Probe for Metal Ions Based on Black Phosphorus Quantum Dots

Yuan

et al. 2020

Adv Materials Inter

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spectroscopy (ICP-AES), and surface plasmon resonance sensing. [4][5][6] Although these methods have high detection performances, the complicated preprocessing process and the excessive cost limit their range of use and the detection rate. On the other hand, with the advancement of fluorescence technology, fluorescence detection techniques for metal ions by monitoring the fluorescence enhancement, quenching, or shifting of peak positions have attracted great interests. This type of method has advantages of strong visibility, simple operation, wide detection range, and low price. [7] Recently, quantum dot (QD) fluorescent probes are gradually receiving more attentions. Compared with the traditional organic fluorescent materials, QD fluorescent probes have narrower emission spectra, better stability, and photobleaching resistance. For example, carbon QDs, [8,9] CdSe QDs, [10] CdS QDs, [11] perovskites QDs, [12] and a combination of functional molecules and QDs have been studied to detect metal ions such as Fe 3+ , Pb 2+ , Hg 2+ , Zn 2+ , and Cd 2+ . [13][14][15][16][17][18] However, currently reported fluorescent probes can be used in only one solvent, it is therefore necessary to develop fluorescent probes with strong selectivity, wide detection range, and low detection limit, which can be used in both aqueous and organic solutions.Black phosphorus (BP) as one of the three major allotropes of phosphorus is a 2D van der Waals material whose atomic layers are stacked by weak van der Waals forces. BP can be stripped into nanosheets down to a single layer or quantum dots with bandgaps varying from 0.3 (bulk BP) to 2.0 eV. Due to this unique property, BP has the size and composition-dependent light absorption, long exciton lifetime, high photo luminescence quantum yield, and ability of surface modification. So far, BP has been used as photothermal agents, photodetectors, photocatalysts, organic photovoltaics, electrocatalysts, and the storage media. [19][20][21][22][23][24] BP has also been studied in the field of sensors, such as humidity sensors, [25] ratiometric fluorescent probes developed by the surface modification of organic molecules, [26,27] field effect transistor detection of metal ions. [28] In addition, BP has a wide range of applications in the biological field, including the medicine, drug carriers, and cancer treatment. [29][30][31] In this research, we have successfully prepared black phosphorus quantum dots (BP QDs) with green fluorescence emission, which can directly detect trace Hg 2+ and Cu 2+ ions without the help of organic molecules. In particular, Fluorescence method for detecting metal ions has advantages of fast detection speed, simple operation, and low price over the conventional methods. Black phosphorus quantum dots (BP QDs) have high photoluminescence quantum yield and modifiable surface, which have great potential in the field of fluorescent probes. In this study, high quality BP QDs are prepared by pyrolysis method and are first time used as trace metal ion probes in both organic solut...

show abstract

Fluorescent black phosphorus quantum dots as label-free sensing probes for evaluation of acetylcholinesterase activity

Cited by 86 publications

References 52 publications

2D Black Phosphorus–Based Biomedical Applications

2D Black Phosphorus–Based Biomedical Applications

Recent Advances on Black Phosphorus for Biomedicine and Biosensing

A Fluorescence Probe for Metal Ions Based on Black Phosphorus Quantum Dots

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