Fluorescence Suppression of 7-Methoxycoumarin upon Inclusion into Cyclodextrins

Wagner, Brian D.; Fitzpatrick, Shannon J.; McManus, Gregory J.

doi:10.1023/b:jiph.0000011779.65838.44

Cited by 32 publications

(17 citation statements)

References 20 publications

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“…studied the spectral properties of 7‐methoxy coumarin in the presence and absence of parent and modified β and γ‐CD in aqueous solution and observed a reduction in fluorescence intensity. They not only reported the same degree of fluorescence suppression in the case of both β‐CD and modified β‐CD but also showed at the same time the HP (hydroxypropyl) substitution in γ‐CD caused higher degree of fluorescence suppression of 7‐MC . Shen et al .…”

Section: Introductionmentioning

confidence: 88%

Photophysical Properties of 7‐(diethylamino)Coumarin‐3‐carboxylic Acid in the Nanocage of Cyclodextrins and in Different Solvents and Solvent Mixtures

Chatterjee

Seth

2012

Photochem & Photobiology

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The photophysical properties of 7-(diethylamino) coumarin-3-carboxylic acid (7-DCCA) were studied in cyclodextrins (α, β, γ,-CDs), different neat solvents and solvent mixtures by using steady state absorption, emission and time-resolved fluorescence spectroscopy. We have observed that with gradual increase in concentration of β-CD the fluorescence quantum yield and lifetime decreased in a regular pattern whereas with gradual increase in concentration of γ-CD the fluorescence quantum yield and lifetime gradually increased. With addition of urea, the fluorescence quantum yield and lifetime of 7-DCCA in CDs increased. Binding constant calculation shows that 7-DDCA forms 1:1 complex with β-CD and with γ-CD it forms 1:1 and 1:2 (guest:host) inclusion complex. We proposed that the dye molecule formed capping complex with β-CD by means of hydrogen bonding and after addition of urea the hydrogen bonding network broke down and part of dye molecule entered inside the cavity of β-CD. The photophysics of 7-DCCA was studied in dioxane-water mixture and ethylene glycol-acetonitrile mixture to know the effect of polarity and viscosity of the media. The photophysics of 7-DCCA was also studied in different neat solvents. It was found that the photophysics of 7-DCCA depended on the structural feature of the solvents and solvent mixtures.

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Section: Introductionmentioning

confidence: 88%

Photophysical Properties of 7‐(diethylamino)Coumarin‐3‐carboxylic Acid in the Nanocage of Cyclodextrins and in Different Solvents and Solvent Mixtures

Chatterjee

Seth

2012

Photochem & Photobiology

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“…As a result, the match in size is very significant in determining the stability of the inclusion complex. [56] Further suppression of the binding between IMC and 2-HP-g-CD may be due to lowering of polarity experienced by the IMC molecule due to the presence of the hydroxylpropyl groups. As a result, the binding affinity of IMC molecule with 2-HP-g-CD is low.…”

Section: Determination Of the Binding Constant And Stoichiometry Frommentioning

confidence: 99%

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

et al. 2014

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Supramolecular host-guest complexation between the nonsteroidal anti-inflammatory drug indomethacin (IMC) and molecular containers were investigated. The weakly fluorescent drug molecule becomes highly fluorescent on complexation with different molecular containers, and time-resolved fluorescence emission spectroscopy reveals that the lifetime components of IMC significantly increase in the presence of molecular containers, compared with the lifetimes in neat water. The respective solid host-guest complexes were synthesised and characterised by Fourier transform infrared and (1) H nuclear magnetic resonance spectroscopic analysis. Microscopy techniques were used to analyse modifications of the surface morphology, owing to the formation of supramolecular complexes. The effect of the molecular container on the optical properties of IMC has also been investigated to determine the effect of nanochannels of different size and structure.

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“…2A). The changes in the fluorescence intensity of guests upon CD inclusion are usually rationalized by comparing the emission properties of the complexed guest with those of the free guest in different solvents (Wagner et al, 2003). The fluorescence quantum yield of QP in propanol, solvent of polarity similar to that of the CD cavity, is smaller than in dimethylformamide-aqueous solution, the medium in which the experiment was performed.…”

Section: -[2'-quinoxalinyl]-phenoxathiin (Qp)mentioning

confidence: 99%

The Determination of the Stoichiometry of Cyclodextrin Inclusion Complexes by Spectral Methods: Possibilities and Limitations

Tablet¹,

Matei²,

Hillebrand³

2012

Stoichiometry and Research - The Importance of Quantity in Biomedicine

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Fluorescence Suppression of 7-Methoxycoumarin upon Inclusion into Cyclodextrins

Cited by 32 publications

References 20 publications

Photophysical Properties of 7‐(diethylamino)Coumarin‐3‐carboxylic Acid in the Nanocage of Cyclodextrins and in Different Solvents and Solvent Mixtures

Photophysical Properties of 7‐(diethylamino)Coumarin‐3‐carboxylic Acid in the Nanocage of Cyclodextrins and in Different Solvents and Solvent Mixtures

Supramolecular Interactions of Nonsteroidal Anti‐inflammatory Drug in Nanochannels of Molecular Containers: A Spectroscopic, Thermogravimetric and Microscopic Investigation

The Determination of the Stoichiometry of Cyclodextrin Inclusion Complexes by Spectral Methods: Possibilities and Limitations

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