Fluorescence Spectroscopic Investigation To Identify the Micelle to Gel Transition of Aqueous Triblock Copolymer Solutions

George, Sony; Kumbhakar, Manoj; Singh, Prabhat; Ganguly, R.; Nath, Sukhendu; Pal, Haridas

doi:10.1021/jp809826c

Cited by 38 publications

(45 citation statements)

References 95 publications

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“…Most of the analyses have been carried out using techniques like DSC, neutron scattering, light scattering, isothermal titration calorimetry, rheology measurement, etc. However, some literature are also available on utilization of fluorescent probe but not in greater details ,. So far, no literature is available to show the use of fisetin as a fluorescent molecular probe to understand the microenvironmental changes of PF127‐surfactant mixed system (in presence of higher concentration of surfactants) with temperature.…”

Section: Introductionsupporting

confidence: 61%

Estimation of Micropolarity and Microviscosity of Pluronic F127–Surfactant Mixed Systems Using Fisetin as a Fluorescent Molecular Probe

Mishra

2019

ChemistrySelect

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Surfactant induced changes in the transition temperature of Pluronic F127 have been studied using differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and fluorescence spectroscopy. The analysis shows that ionic surfactants (cetyltrimethylammonium bromide (CTAB) and sodium dodecyl sulfate (SDS)) significantly alter the transition temperature of PF127, whereas the effect of a nonionic surfactant (Tween20) is not significant. The sol-gel transition temperature decreases from PF127 (22°C) to PF127 + TW20 (21°C) to PF127 + CTAB (18°C), whereas there is no sol-gel transition temperature observed for PF127 + SDS. Using the anionic emission and fluorescence anisotropy value of fisetin, the local polarity and microviscosity in the immediate neigh-bourhood of fisetin in pluronic-surfactant systems have been estimated. Rotational correlation time along with the timeresolved fluorescence anisotropy study gives additional information about the variation in medium microviscosity (PF127) with temperature in the absence and presence of surfactants. Variation in both polarity and microviscosity of the PF127surfactant mixed systems follows a reverse trend at sol and gel phases. Fluorescence lifetime studies indicate that fisetin molecules distribute in the different microdomains of PF127surfactant mixed systems. The local environmental heterogeneity at different microdomains of PF127-surfactant mixed system is confirmed from lifetime distribution analysis of fisetin FT* emission.[a] J.

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Section: Introductionsupporting

confidence: 61%

Estimation of Micropolarity and Microviscosity of Pluronic F127–Surfactant Mixed Systems Using Fisetin as a Fluorescent Molecular Probe

Mishra

2019

ChemistrySelect

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“…Similarly, other fluorescent probes such as coumarin derivatives bearing a long alkyl chain have been used to report on the micelle‐to‐gel transition in triblock‐copolymer systems including F127 as a function of concentration and temperature. Such coumarin derivatives were shown to be sensitive to the phase transition in pluronic systems . The spin probe method of EPR spectroscopy is already a classical tool in probing micropolarity changes or inhomogeneities of a given system .…”

Section: Introductionmentioning

confidence: 99%

A Comparison of the Behavior of Monomolecular and Dual Molecular Probes in F127/Cyclodextrin Systems

Baratoiu

Mocanu

Matei

et al. 2019

Macro Chemistry & Physics

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Molecular probes are often used to describe local interactions and to characterize inhomogeneities in complex systems. In this study, two series of monomolecular probes (paramagnetic or fluorescent) and a series of dual molecular probes are used to evaluate local changes and the regions targeted by these probes in three pluronic F127 systems, in the absence and in the presence of 2‐hydroxypropyl‐β‐cyclodextrin, which have been previously characterized. All molecular probes used in this study have as a common structural unit the short oligoethylene chains that link (2,2,6,6‐Tetramethylpiperidin‐1‐yl)oxyl (TEMPO) and/or pyrene moieties. Using these probes, changes in hydrophobicity inside the pluronic micelles are evidenced and the micelle‐to‐gel phase transition is characterized.

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“…Coumarins are relatively photostable and their excitation ( λ ex ) and emission maxima ( λ em ) in many cases are long enough to minimize “background” fluorescence of cellular components, tissues and biological fluids. These properties make coumarins as useful fluorescent probes in investigating various chemical, physiological and physiochemical processes …”

Section: Introductionmentioning

confidence: 99%

Microwave‐Expedited Green Synthesis, Photophysical, Computational Studies of Coumarin‐3‐yl‐thiazol‐3‐yl‐1,2,4‐triazolin‐3‐ones and Their Anticancer Activity

et al. 2018

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Mild and efficient synthesis of 5‐methyl‐4‐[(2Z)‐4‐(2‐oxo‐2H‐chromen‐3‐yl)‐2‐(4‐arylimino)thiazol‐3(2H)‐yl]‐2‐(4‐aryl)‐2H‐1,2,4‐triazol‐3(4H)‐ones 7(h–s) has been developed using microwave assisted multicomponent route. The molecular structures of these novel compounds were characterized and the photophysical and thermal properties were investigated elaborately using absorption, fluorescence, fluorescence decay lifetimes and thermo gravimetric analysis. Solvatochromism was studied as a function of polarity of the solvents. The ground and excited states of electronic geometric optimizations were computed using density functional theory (DFT and TD‐DFT). The orientation of atomic orbitals and their energies were supported by HOMO‐LUMO calculations. Electrostatic potential (ESP) maps indicated the electron density predicting the reactive sites. Compounds 7(h–s) were docked into the epidermal growth factor receptor (EGFR) tyrosine kinase domain which formed a stable complex with good C‐score values. The title compounds were evaluated for their anticancer activity against A549, MDA‐MBA‐231, HeLa and K562 cancer cell lines which showed sensitivity against most of the tested compounds.

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Fluorescence Spectroscopic Investigation To Identify the Micelle to Gel Transition of Aqueous Triblock Copolymer Solutions

Cited by 38 publications

References 95 publications

Estimation of Micropolarity and Microviscosity of Pluronic F127–Surfactant Mixed Systems Using Fisetin as a Fluorescent Molecular Probe

Estimation of Micropolarity and Microviscosity of Pluronic F127–Surfactant Mixed Systems Using Fisetin as a Fluorescent Molecular Probe

A Comparison of the Behavior of Monomolecular and Dual Molecular Probes in F127/Cyclodextrin Systems

Microwave‐Expedited Green Synthesis, Photophysical, Computational Studies of Coumarin‐3‐yl‐thiazol‐3‐yl‐1,2,4‐triazolin‐3‐ones and Their Anticancer Activity

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