Fluorescence relay enhancement sequential recognition of Cu2+ and CN− by a new quinazoline derivative

A colorimetric chemosensor for the sequential recognition of Mercury (II) and iodide in aqueous media

“…Hence the iodide content of breast milk and urine is often required for nutritional, metabolic, and epidemiological studies of thyroid disorder [6]. Therefore, developing chemosensors that can detect iodide is strongly desired [7][8][9][10][11][12][13][14][15][16][17][18].Herein, we report the synthesis, characterization, and sensing properties of 1, based on the combination of the hydrazone moiety and the dimethylaniline one, as a selective colorimetric sequential chemosensor for Hg 2+ and I − . The receptor 1 could detect Hg 2+ by colorimetric response with high selectivity in aqueous media.…”

Quinazoline pharmacophore in therapeutic medicine

“…Linear and angular 4',5'-dimethylfuroquinazolines proved to intercalate within the DNA double helix, however they could not photo-bind DNA bases in the presence of ultraviolet radiation (Miolo et al, 2014). Fluorescence relays increased sequential identification of Cu 2+ and CN − through effect of novel quinazoline scaffold (Liu et al, 2013;Tang et al, 2013) and their role as turn on fluorescence for cysteine and chemodosimeter for NO has also been reported (Anand et al, 2014). Some quinazoline motifs were shown to display bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice (Špulák et al, 2014).…”

Turn-on fluorescence sensing of cyanide ions in aqueous solution

“…In recent years, some organic molecules and transition metal complexes capable of signaling the presence of cyanide by pronounced changes in their absorption and emission properties have been already identified [14][15][16]. Some of these chemosensors can even detect micromolar amounts of cyanide [17][18][19].…”