Fluorescence probe for selectively monitoring biothiols within cells and mouse depression diagnosis

Ma, Junyan; Xu, Yaoyu; Kong, Xiangtao; Wei, Yuying; Meng, Dan; Zhang, Zhenxing

doi:10.1016/j.biopha.2022.113647

Cited by 15 publications

(3 citation statements)

References 51 publications

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“…In addition, GSH plays an important role in maintaining the physiological functions of cells including intracellular redox reaction, foreign body metabolism, signal transduction, and gene regulation . As studied, the fluorescent probe has been considered as the accurate method for the detection of biothiol , due to its high selectivity and sensitivity. However, this fluorescent probe method caused some inevitable disadvantages, such as high requirements for instruments and equipment, inconvenient pretreating of samples, and so on.…”

Section: Introductionmentioning

confidence: 99%

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO₄ to Detect and Distinguish Biologically Important Thiols

Hao

Liu

Wang

et al. 2023

ACS Appl. Nano Mater.

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In order to establish a rapid, accurate, and simple method for monitoring and analyzing the biological physiological state, we constructed a colorimetric sensor array based on the peroxidase-like activity of nanozymes (CoMoO4 and Por-CoMoO4) for the determination of five kinds of biothiols. The peroxidase-like activity of CoMoO4 has been greatly enhanced by the introduction of porphyrin (Por), due to the synergistic interaction between porphyrin and CoMoO4. Experimental data of the radical scavenger and fluorescence probe verify the generation of a superoxide radical (•O2 –) during the catalytic reaction. Because different biothiols have different inhibiting effects on the catalytic activity of two nanozymes, each biothiol has a unique fingerprint with the aid of a chromogenic substrate (TMB). Through linear discriminant analysis, captopril (CAP), cysteine (Cys), homocysteine (Hcy), dithiothreitol (DTT), and glutathione (GSH) can be well identified in a certain range of concentrations. Different concentrations of biothiols and different proportions of mixed biothiols can be identified. It is expected that this study will provide a simple and rapid method for the identification of structural analogues, contributing to the monitoring of human life and health.

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Section: Introductionmentioning

confidence: 99%

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO₄ to Detect and Distinguish Biologically Important Thiols

Hao

Liu

Wang

et al. 2023

ACS Appl. Nano Mater.

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“…Unfortunately, the pathogenesis of depression is essentially unknown, severely hindering progress in developing new treatments (e.g., antidepressants). Enormous efforts are therefore ongoing to try and understand the molecular and biological mechanisms of depression, − including the development of a multitude of new probes for the sensing, visualization, and tracking of depression-correlated biomarkers (Figure ).…”

Section: Fluorescent Probes For Neurological Diseasesmentioning

confidence: 99%

“…In 2022, Ma et al 69 investigated alternatives for tracking Cys in depression, developing fluorescent probe 18 that specifically monitors Cys. With coumarin as the fluorophore and a maleimide group as the Cys-recognition group, the fluorescence emission is suppressed by PeT between the fluorophore and maleimide group.…”

Section: Fluorescent Probes For Neurological Diseasesmentioning

confidence: 99%

Fluorescent Probes for Disease Diagnosis

Wang,

Ding,

Groleau

et al. 2024

Chem. Rev.

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The identification and detection of disease-related biomarkers is essential for early clinical diagnosis, evaluating disease progression, and for the development of therapeutics. Possessing the advantages of high sensitivity and selectivity, fluorescent probes have become effective tools for monitoring disease-related active molecules at the cellular level and in vivo. In this review, we describe current fluorescent probes designed for the detection and quantification of key bioactive molecules associated with common diseases, such as organ damage, inflammation, cancers, cardiovascular diseases, and brain disorders. We emphasize the strategies behind the design of fluorescent probes capable of disease biomarker detection and diagnosis and cover some aspects of combined diagnostic/ therapeutic strategies based on regulating disease-related molecules. This review concludes with a discussion of the challenges and outlook for fluorescent probes, highlighting future avenues of research that should enable these probes to achieve accurate detection and identification of disease-related biomarkers for biomedical research and clinical applications. CONTENTS 5.3.

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A dual-functional NIR fluorescence probe for detecting hypochlorous acid and bisulfite in biosystem

Ma,

Kong,

Zhao

et al. 2024

Analytica Chimica Acta

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Fluorescence probe for selectively monitoring biothiols within cells and mouse depression diagnosis

Cited by 15 publications

References 51 publications

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO₄ to Detect and Distinguish Biologically Important Thiols

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO₄ to Detect and Distinguish Biologically Important Thiols

Fluorescent Probes for Disease Diagnosis

A dual-functional NIR fluorescence probe for detecting hypochlorous acid and bisulfite in biosystem

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Fluorescence probe for selectively monitoring biothiols within cells and mouse depression diagnosis

Cited by 15 publications

References 51 publications

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO4 to Detect and Distinguish Biologically Important Thiols

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO4 to Detect and Distinguish Biologically Important Thiols

Fluorescent Probes for Disease Diagnosis

A dual-functional NIR fluorescence probe for detecting hypochlorous acid and bisulfite in biosystem

Contact Info

Product

Resources

About

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO₄ to Detect and Distinguish Biologically Important Thiols

Nanozyme Sensor Array Based on Porphyrin-Modified CoMoO₄ to Detect and Distinguish Biologically Important Thiols