Fluorescence probe for monosaccharide based on anionic polyelectrolyte and cationic pyridine quaternary ammonium salt

Feng, Liheng; Yin, Ninghua; Wang, Xiaoju; Wang, Zhijun

doi:10.1016/j.snb.2013.02.005

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…Polymer-based systems are interesting candidates for in vivo (diagnostics) and in vitro measurements of glucose, and a recent example of a system for diagnostics comes from Feng et al [ 73 ], where a tridentate pyridinium boronic acid forms a non-fluorescent complex with a pyrene-containing polymeric polyelectrolyte ( Figure 10 and Figure 11 ). The system shows some discrimination, but still, the main problem is achieving selectivity for glucose in the presence of fructose.…”

Section: Immobilized Systemsmentioning

confidence: 99%

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Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing

Hansen

Christensen

2013

Biosensors

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Continuous glucose monitoring (CGM) is crucial in order to avoid complications caused by change in blood glucose for patients suffering from diabetes mellitus. The long-term consequences of high blood glucose levels include damage to the heart, eyes, kidneys, nerves and other organs, among others, caused by malign glycation of vital protein structures. Fluorescent monitors based on arylboronic acids are promising candidates for optical CGM, since arylboronic acids are capable of forming arylboronate esters with 1,2-cis-diols or 1,3-diols fast and reversibly, even in aqueous solution. These properties enable arylboronic acid dyes to provide immediate information of glucose concentrations. Thus, the replacement of the commonly applied semi-invasive and non-invasive techniques relying on glucose binding proteins, such as concanavalin A, or enzymes, such as glucose oxidase, glucose dehydrogenase and hexokinases/glucokinases, might be possible. The recent progress in the development of fluorescent arylboronic acid dyes will be emphasized in this review.

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Section: Immobilized Systemsmentioning

confidence: 99%

“… Fluorescence intensity at 467 nm for the system after the addition of 50.0 mM of monosaccharides at pH 7.4 buffer solution. Glu = glucose, Fru = fructose, Man = mannose, Rib = ribose, Ara = arabinose, Xyl = xylose (reproduced from [ 73 ]). …”

Section: Immobilized Systemsmentioning

confidence: 99%

Recent Advances in Fluorescent Arylboronic Acids for Glucose Sensing

Hansen

Christensen

2013

Biosensors

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“…Recent studies have indicated increased serum and urinary fructose concentrations in diabetic patients [4,5] besides glucose. A variety of conventional laboratory techniques are currently available for the detection of fructose, e. g., chromatography [6]; flourometry [5,7,8], colorimetry [5,9], electrophoresis, titration, spectrophotometry [5,10,11] etc. Although these methods can provide an accurate determination of fructose, the methods are tedious, require rigorous sample pre-treatment, sophisticated equipment, highly trained personnel, immense amount of attention in the analysis [12,13].…”

Section: Introductionmentioning

confidence: 99%

Non‐enzymatic Fructose Sensor Based on Co₃O₄ Thin Film

2017

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In this study, we report on the selective of fructose on Co3O4 thin film electrode surface. A facile chemical solution deposition technique was used to fabricate Co3O4 thin film on fluorine doped tin oxide, FTO, glass. Electrode characterization was done using XRD, HRTEM, SEM, AFM, and EIS. The constructed sensor exhibited two distinctive linear ranges (0.021–1.74 mM; 1.74–∼15 mM) covering a wide linear range of up to ∼15 mM at an applied potential of +0.6 V vs Ag/AgCl in 0.1 M NaOH solution. The sensor demonstrated high, reproducible and repeatable (R.S.D of <5 %) sensitivity of 495 (lower concentration range) & 53 (higher concentration range) μA cm−2 mM−1. The sensor produced a low detection limit of ∼1.7 μM (S/N=3). The electrode was characterised by a fast response time of <6 s and long term stability. The repeatability and stability of the electrode resulted from the chemical stability of Co3O4 thin film. The sensor was highly selective towards fructose compared to the presence of other key interferences i. e. AA, AC, UA. The ease of the electrode fabrication coupled with good electrochemical activity makes Co3O4 thin film, a promising candidate for non‐enzymatic fructose detection.

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“…However, the most important clue is the great sensitivity of fluorophore to microenvironment changes, providing detailed information about the properties of the investigated system (like micropolarity, microviscosity). By tailoring the fluorophore structure (derivatization, attaching a lateral chain, immobilizing on a polymer chain) one obtains suitable chemosensors for biological, environmental or other purposes [6][7][8][9][10][11]. Depending on application, the fluorophore can be probe or label.…”

Section: Introductionmentioning

confidence: 99%