Fluorescence-guided surgery of malignant gliomas based on 5-aminolevulinic acid: paradigm shifts but not a panacea

Moiyadi, Aliasgar; Syed, Parvez; Srivastava, Sanjeeva

doi:10.1038/nrc3566-c1

Cited by 13 publications

(20 citation statements)

References 8 publications

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“…Additionally, we profiled IDH1 mutant tumor cells distinguished by 5-Aminolevulinic acid (5-ALA) uptake pattern (populations stained for tumor cellularity 24 ) (GBM10, Fig. 3e–f, Supplementary Figs.…”

Section: Main Textmentioning

confidence: 99%

“…6–7). Previous glioma studies suggested that low pathologic grade is associated with low uptake of 5-ALA 24,25 ; however, genomic determinants for 5-ALA uptake remain elusive. Using single cell transcriptome analysis, we found predominant enrichment of proneural cells on 5-ALA (-) sample, supporting previous observations that GBM cells may be evolved from proneural precursors ( p <0.01, Fig.…”

Section: Main Textmentioning

confidence: 99%

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Spatiotemporal genomic architecture informs precision oncology in glioblastoma

et al. 2017

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Precision medicine in cancer proposes that genomic characterization of tumors can inform personalized targeted therapies1–5. This proposition, however, is complicated by spatial and temporal heterogeneity6–14. Here we study genomic and expression profiles across 127 multi-sector or longitudinal specimens from 52 glioblastoma (GBM) patients. Using bulk and single-cell data, we find that samples from the same tumor mass share genomic and expression signatures, while geographically separated multifocal tumors and/or long-term recurrent tumors are seeded from different clones. Chemical screening of patient-derived glioma cells (PDCs) shows that therapeutic response is associated to genetic similarity, and multifocal tumors enriched with PIK3CA mutations have a heterogeneous drug response pattern. Importantly, we show that targeting truncal events is more efficacious in reducing tumor burden. In summary, this work demonstrates that evolutionary inference from integrated genomic analysis in multi-sector biopsies can inform targeted therapeutic interventions for GBM patients.

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Section: Main Textmentioning

confidence: 99%

Section: Main Textmentioning

confidence: 99%

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

et al. 2017

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“…Photodynamic therapy (PDT) is a promising therapeutic modality for metastatic melanoma skin cancers [1][2][3]. Three main requisites for an effective PDT include a photosensitizer (PS) delivered to tumor tissues, light with an appropriate wavelength, and oxygen in the tumor site [4,5].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy of melanoma skin cancer using carbon dot – chlorin e6 – hyaluronate conjugate

et al. 2015

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“…5-ALA has also been used to identify urothelial cancer using fluorescence guided cystoscopy(Jocham, Stepp and Waidelich, 2008). A persistent concern with 5-ALA approach is the poor sensitivity and a negative predictive value, especially for surgical guidance of glioma resection (Moiyadi, Syed and Srivastava, 2014). …”

Section: Fluorescent Agents Used In Image-guided Surgerymentioning

confidence: 99%

Real-Time Fluorescence Image-Guided Oncologic Surgery

Mondal

Gao

Zhu

et al. 2014

Advances in Cancer Research

133

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Medical imaging plays a critical role in cancer diagnosis and planning. Many of these patients rely on surgical intervention for curative outcomes. This requires a careful identification of the primary and microscopic tumors, and the complete removal of cancer. Although there have been efforts to adapt traditional imaging modalities for intraoperative image guidance, they suffer from several constraints such as large hardware footprint, high operation cost, and disruption of the surgical workflow. Because of the ease of image acquisition, relatively low cost devices and intuitive operation, optical imaging methods have received tremendous interests for use in real-time image-guided surgery. To improve imaging depth under low interference by tissue autofluorescence, many of these applications utilize light in the near-infra red (NIR) wavelengths, which is invisible to human eyes. With the availability of a wide selection of tumor-avid contrast agents, advancements in imaging sensors, electronic and optical designs, surgeons are able to combine different attributes of NIR optical imaging techniques to improve treatment outcomes. The emergence of diverse commercial and experimental image guidance systems, which are in various stages of clinical translation, attests to the potential high impact of intraoperative optical imaging methods to improve speed of oncologic surgery with high accuracy and minimal margin positivity.

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Fluorescence-guided surgery of malignant gliomas based on 5-aminolevulinic acid: paradigm shifts but not a panacea

Cited by 13 publications

References 8 publications

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Spatiotemporal genomic architecture informs precision oncology in glioblastoma

Photodynamic therapy of melanoma skin cancer using carbon dot – chlorin e6 – hyaluronate conjugate

Real-Time Fluorescence Image-Guided Oncologic Surgery

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