Fluorescence‐guided surgery for non‐melanoma and melanoma skin cancer: Case series and a brief review of the literature

Abstract

Surgery is the primary mode of treatment for non-melanoma (NMSC) and melanoma skin cancer (MSC). The main purpose of surgery is to completely remove the neoplastic lesion, since the presence of residual tumor cells is considered a strong predictor of tumor recurrence, new surgical approach, and, therefore, survival. 1Fluorescence can be utilized to define tumor margins before and during surgery, improving the possibility of radical resection. More

Smartphone-based dual radiometric fluorescence and white-light imager for quantification of protoporphyrin IX in skin

“…Despite the widespread clinical use of skin PDT, the primary treatment outcome of AK lesion clearance rates varies widely, which is primarily caused by heterogeneous accumulation of the photosensitizer PpIX between patients and between lesions 6 , 7 . Furthermore, the presence and accumulation of PpIX in skin is also related to conditions like porphyria 8 , 9 and can be used for the preoperative mapping of non-melanoma skin cancers 10 , 11 . Therefore, the ability to visualize and quantify skin PpIX in clinical settings can be used to help guide critical decisions at the point-of-care, including mitigative actions to improve patient outcomes.…”

“… 6 , 7 Furthermore, the presence and accumulation of PpIX in skin is also related to conditions like porphyria 8 , 9 and can be used for the preoperative mapping of non-melanoma skin cancers. 10 , 11 Therefore, the ability to visualize and quantify skin PpIX in clinical settings can be used to help guide critical decisions at the point-of-care, including mitigative actions to improve patient outcomes. Imaging and spectroscopy techniques have shown potential for PpIX quantification, with fluorescence (FL) imaging techniques demonstrating great promise for non-invasive measurement of PpIX in the skin.…”